Mesoporous bioactive ceramics that form scaffolds by prototyping are excellent candidates for bone regeneration. This review by Salinas, Esbrit and Vallet-Regí describes the use of bioceramics such as those based on oxides, phosphates, carbonates, nitrides, carbides, carbons and glasses for bone repair.
(Biomater. Sci., 2012, DOI: 10.1039/c2bm00071g, Advance article)
The problems associated with gene-delivery vectors for human gene therapy as discussed in this Review by Yue and Wu. The Review focuses on how polymeric vectors navigate each intracellular obstacle or “slit”. Intracellular trafficking mechanisms of DNA-polymer complexes are particularly focussed upon.
(Biomater. Sci., 2012, DOI: 10.1039/ c2bm00030j, Advance article)
Biomaterials for bone replacement must be able to regulate osteoblast and osteoclast functions to maintain the dynamics of bone remodelling. In this paper, Bose and co-workers report osteoclast-like cell differentiation and resorption activity in the presence of β-tricalcium phosphate and Zn-and Sr-doped tricalcium phosphate materials in an in vitro study. The presence of Zn was found to reduce activity in all cultures, but the osteoclast-like cellular resorption process was not affected.
(Biomater. Sci., 2012, DOI: 10.1039/ c2bm00012a, Advance article)