Analyst Blog

Professor Pavel Matousek

In addition to the excellent themed issue collection on Single Entities, there are other high-profile names in the latest issue of Analyst.

Editorial Board member Pavel Matousek and collaborators employ transmission Raman spectroscopy for the first time to analyse model formulations comprising tabletted cocrystals.

Transmission Raman spectroscopy for quality control in model cocrystal tablets
Jonathan C. Burley, Aalae Alkhalil, Matthew Bloomfield and Pavel Matousek
Analyst, 2012, 137, 3052-3057
DOI: 10.1039/C2AN35216H

Another Editorial Board member, Graham Cooks, also features. In his paper, leaf spray mass spectrometry is explored as a fast and simple way for direct analysis of glycosides in Stevia leaves without sample pretreatment.

Professor Graham Cooks

Direct analysis of steviol glycosides from Stevia leaves by ambient ionization mass spectrometry performed on whole leaves
J. Isabella Zhang, Xin Li, Zheng Ouyang and R. Graham Cooks
Analyst, 2012, 137, 3091-3098
DOI: 10.1039/C2AN16263F

There is also a collection of HOT papers to take a look at…

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Miao et al., Analyst, 2012, Advance Article

This HOT article features work from Xintao Shuai and colleagues of Sun Yat-Sen University, Guangzhao, China.

They present a novel, sensitive Cu²⁺ sensor based on the use of dynamic light scattering (DLS) to detect difference in the hydrodynamic diameter of gold nanoparticles (AuNPs). The ability of DNA to adsorb on the AuNPs changes with the presence of Cu²⁺, affecting the disperse state of the AuNPs and, therefore, their average hydrodynamic diameter.

The Cu²⁺ ion plays a key role in many metabolic processes, so being able to accurately determine levels of Cu²⁺ is important in various aspects of biology.

The authors applied their technique to water samples and say that it is both simple and timesaving, with the potential to be extended to other bioassays in the future.

A highly sensitive sensor for Cu²⁺ with unmodified gold nanoparticles and DNAzyme by using the dynamic light scattering technique
Xiangmin Miao, Liansheng Ling, Du Cheng and Xintao Shuai
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35217F

This paper will be free to access until 21 June 2012.

It’s been a busy month with so many great papers, so here are some HOT articles from Analyst that you might have missed this May!

Why not take a look, they will be free to read for 2 weeks.

Ultra-low level optical detection of mercuric ions using biogenic gold nanotriangles
Amit Singh, Renu Pasricha and Murali Sastry
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35162E

Convergence of Dip-Pen Nanolithography and acoustic biosensors towards a rapid-analysis multi-sample microsystem
Konstantinos Mitsakakis, Sylwia Sekula-Neuner, Steven Lenhert, Harald Fuchs and Electra Gizeli
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35156K

Surface-assisted laser desorption–ionization mass spectrometry on titanium dioxide (TiO₂) nanotube layers
Gaëlle Piret, Doohun Kim, Hervé Drobecq, Yannick Coffinier, Oleg Melnyk, Patrik Schmuki and Rabah Boukherroub
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35207A

Amplified quenching of electrochemiluminescence from CdS sensitized TiO₂ nanotubes by CdTe–carbon nanotube composite for detection of prostate protein antigen in serum
Chun-Yuan Tian, Wei-Wei Zhao, Jing Wang, Jing-Juan Xu and Hong-Yuan Chen
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35493D

Nafion–CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine
Ashley E. Ross and B. Jill Venton
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35297D

High throughput single molecule tracking for analysis of rare populations and events
Robert Walder, Mark Kastantin and Daniel K. Schwartz
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN16219A

Fluorogenic and chromogenic probe for rapid detection of a nerve agent simulant DCP
Wei-hui Wu, Jun-jun Dong, Xin Wang, Jian Li, Shao-hui Sui, Gao-yun Chen, Ji-wei Liu and Ming Zhang
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35428D

Mabbott et al., Analyst, 2012,137, 2791-2798

Plenty of HOT articles to take a look at in the latest issue of Analyst. Amongst those highlighted below is a paper from Editorial Board member Professor Duncan Graham of Strathclyde University, Glasgow, UK, co-authored by Professor Royston Goodacre of the University of Manchester, UK. They have developed a fast and cost-effective approach for the synthesis of substrates used in surface enhanced Raman scattering (SERS) using galvanic displacement.

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A novel screen-printed electrode array

Li and Long et al., Analyst, 2012, Advance Article

Da-Wei Li, Yi-Tao Long and colleagues from the East China University of Science and Technology, China, have developed a novel screen-printed electrode array and tested it on a variety of biological samples and environmental pollutants. The device could take multiple measurements of different analytes simultaneously. The sample size required was also much smaller than regular screen-printed electrodes.

A novel screen-printed electrode array for rapid high-throughput detection
Shuai Mu, Xiao Wang, Yuan-Ting Li, Yang Wang, Da-Wei Li and Yi-Tao Long
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35261C

A new approach to proteolysis

Yang and Wei et al., Analyst, 2012, 137, 2757

From Fudan University in China comes the research of Dong Yang, Liming Wei and co-workers who have been developing an efficient and rapid way to identify various proteins through MALDI MS combined with immobilization of trypsin on graphene oxide.

Immobilization of trypsin on graphene oxide for microwave-assisted on-plate proteolysis combined with MALDI-MS analysis
Guobin Xu, Xiaoyi Chen, Jianhua Hu, Pengyuan Yang, Dong Yang and Liming Wei
Analyst, 2012, 137, 2757-2761
DOI: 10.1039/C2AN35093A

Fernandez et al., Analyst, 2012, Advance Article

It is alarming to note that the counterfeit drug trade in both developing and developed countries is on the increase. Facundo M. Fernández from the Georgia Institute of Technology, USA, and colleagues from the USA and Switzerland have been working on a method to determine the real drugs from the fake ones. They have accomplished this through the detection of active pharmaceutical ingredients by coupling laser ablation/desorption electrospray ionization to atmospheric pressure drift tube ion mobility spectrometry. Click on the title below to read more.

Coupling laser ablation/desorption electrospray ionization to atmospheric pressure drift tube ion mobility spectrometry for the screening of antimalarial drug quality
Glenn A. Harris, Stephan Graf, Richard Knochenmuss and Facundo M. Fernández
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35431D