Analyst Blog

Check out our latest HOT articles just published in Analyst! They are all free for you to read until July 8^th. Enjoy!

Electrochemiluminescent polymer films with a suitable redox “turn-off” absorbance window for remote selective sensing of Hg²⁺
Qinghai Shu, Catherine Adam, Neso Sojic  and  Michael Schmittel  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00545C

A novel LTCC electrochemical cell construction and characterization: a detection compartment for portable devices
Naira Canevarolo Pesquero, Mário Ricardo Gongora-Rubio and  Hideko Yamanaka 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00648D 

A rapid, topographical platelet activation assay
R. Woolley, Ú. Prendergast, B. Jose, D. Kenny and C. McDonagh 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00046J 
 
Exploring the origins of the apparent “electrocatalytic” oxidation of kojic acid at graphene modified electrodes
Luiz C. S. Figueiredo-Filho, Dale A. C. Brownson, Orlando Fatibello-Filho and Craig E. Banks  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00856H

An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines
Yanyan Yu, Xiuwen Pan, Ying Ding, Xiaohui Liu, Hailin Tang, Chengpin Shen, Huali Shen and Pengyuan Yang 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00517H  

Synchrotron Fourier transform infrared (FTIR) analysis of single living cells progressing through the cell cycle
Donna R. Whelan, Keith R. Bambery, Ljiljana Puskar, Don McNaughton and Bayden R. Wood 
Analyst, 2013,138, 3891-3899
DOI: 10.1039/C3AN00316G

Instrument with a thin fibre optic Raman probe mounted inside a hollow tactile resonance sensor

In some types of cancers, such as in prostate cancers, surgical removal of the entire organ provides the most effective treatment option. Unfortunately, after removal of the prostate a few tumor cells may remain and cause a recurrence of the disease in the patient. If the surgical area could be tested shortly after removal, it would determine if any cancerous cells remain and improve patient mortality.

Morgan Nyberg and researchers at Umea University in Sweden have harnessed the power of two techniques in a single probe to differentiate healthy and cancerous cells: Raman spectroscopy and tactile resonance method (TRM). Although an inherently weak effect, Raman spectroscopy can identify tissues based on their unique vibrational spectra. TRM measures tissue stiffness and successfully detects cancerous tissues in a prostate. However, it fails at the cellular level in differentiating between other benign growth tissues from cancerous ones. The combination of these two techniques removes the drawbacks of implementing Raman spectroscopy in surgery such as interfering ambient light and increases the specificity lacking in TRM. The researchers have successfully identified muscle and fat tissues from an animal sample and plan to move onto prostate tissue samples in the near future.

To know more about this ressearch, please access the full article below. This paper will be free to read for the next three weeks.

Optical fibre probe NIR Raman measurements in ambient light and in combination with a tactile resonance sensor for possible cancer detection
Morgan Nyberg, Kerstin Ramser and   Olof A. Lindahl
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00243H

Enjoy our new selected HOT articles just published in Analyst! They will be free for you until July 1st. Have a read now!

An iTRAQ Based Quantitative Proteomic Strategy to Explore Novel Secreted Proteins in Metastatic Hepatocellular Carcinoma Cell Lines
Yanyan Yu, Xiuwen Pan, Ying Ding, Xiaohui Liu, Hailin Tang, Cheng-Pin Shen, Huali Shen and Pengyuan Yang  
Analyst, 2013, Accepted Manuscript
DOI: 10.1039/C3AN00517H 
 

Plasmon enhanced fluoro-immunoassay using egg yolk antibodies for ultra-sensitive detection of herbicide diuron
Priyanka Sharma, Manil Kakkar, Ashok Ganguli, Aman Bhasin and C Raman Suri  
Analyst, 2013, Accepted Manuscript
DOI: 10.1039/C3AN00505D 

A multi-parametric microarray for protein profiling: simultaneous analysis of 8 different cytochromes via differentially element tagged antibodies and laser ablation ICP-MS
Larissa Waentig, Sandra Techritz, Norbert Jakubowski and Peter H. Roos  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00468F

Aptamer based electrochemical biosensor for tumor necrosis factor-alpha detection in whole blood
Ying Liu, Qing Zhou and Alexander Revzin  
Analyst, 2013, Accepted Manuscript
DOI: 10.1039/C3AN00818E

Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells
Laven Mavarani, Dennis Petersen, Samir F. El-Mashtoly, Axel Mosig, Andrea Tannapfel, Carsten Köttinga and  Klaus Gerwert  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00370A 
 

Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool
David I. Ellis, David P. Cowcher, Lorna Ashton, Steve O’Hagan and Royston Goodacrea  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00698K

Nanoparticle embedded enzymes for improved lateral flow sensors
Veli C. Özalp, Uğur S. Zeydanlı, Anita Lunding, Murat Kavruk, M. Tufan Öz, Füsun Eyidoğan, Lars F. Olsen and Hüseyin A. Ökteme 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00733B 
 

Surface-enhanced Raman spectroscopy studies of yellow organic dyestuffs and lake pigments in oil paint
Hannah E. Mayhew, David M. Fabian, Shelley A. Svoboda and Kristin L. Wustholz
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00611E

CyN1 chemosensor for detection of palladium

Palladium is all around us, from the catalytic converters in our cars to watches, jewellery and mobile phones. However, palladium ions can bind to DNA and proteins, leading to concerns that accumulation of the metal in human tissue may pose a health risk.

Fengling Song and Xiaojun Peng from the Dalian University of Technology, China, have developed a new near-infrared ratiometric fluorescent chemosensor for palladium. The CyN1 molecule is based on the structure of a cyanine dye and undergoes a Tsuji-Trost reaction in the presence of catalytic amounts of palladium.

The CyN1 sensor offers significant advantages over traditional methods of palladium detection such as atomic absorption spectroscopy (AAS) and inductively coupled plasma mass spectrometry (ICP-MS), which require expensive instrumentation and highly skilled analysts.

Demonstrating the potential bioapplications of the chemosensor, the authors used fluorescence imaging to conduct the first in vivo visualisation of palladium in living mice.

A near-infrared and ratiometric fluorescent chemosensor for palladium
Junyu Wang, Fengling Song,* Jingyun Wang and Xiaojun Peng*
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00616F

Analyst Issue 12

Take a look at our latest  HOT articles! They will be free to read until June 14^th. Have a read now!

Determination of cell cycle phases in live B16 melanoma cells using IRMS
Diana E. Bedolla, Saša Kenig, Elisa Mitri, Paolo Ferraris, Alessandro Marcello, Gianluca Grenci and   Lisa Vaccari 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00318C

Reagent-free monitoring of multiple clinically relevant parameters in human blood plasma using a mid-infrared quantum cascade laser based sensor system
Markus Brandstetter, Tamara Sumalowitsch, Andreas Genner, Andreas E. Posch, Christoph Herwig, Andreas Drolz, Valentin Fuhrmann, Thomas Perkmann and   Bernhard Lendl
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00300K

A compact high resolution ion mobility spectrometer for fast trace gas analysis
Ansgar T. Kirk, Maria Allers, Philipp Cochems, Jens Langejuergen and   Stefan Zimmermann  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00231D

A label-free amplified fluorescence DNA detection based on isothermal circular strand-displacement polymerization reaction and graphene oxide
Zhen Li, Wenping Zhu, Jinwen Zhang, Jianhui Jiang, Guoli Shen and   Ruqin Yu  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00421J

FTIR micro-spectral images to monitor cell division

Take a look at our New HOT Articles free to read until June 3^rd. Click on the links below and discover all about the latest research published in Analyst:

Employing aqueous CdTe quantum dots with diversified surface functionalities to discriminate between heme (Fe(II)) and hemin (Fe(III))
Jishu Han, Ziwei Zhou, Xinyuan Bu, Shoujun Zhu, Hao Zhang, Haizhu Sun and   Bai Yang 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00310H

A disposable electrochemical immunosensor for the determination of leptin in serum and breast milk
Irene Ojeda, María Moreno-Guzmán, Araceli González-Cortés, Paloma Yáñez-Sedeño and   José M. Pingarrón 
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00183K

Microfluidic assay to monitor anticoagulation therapy

Mepanipyrim haptens and antibodies with nanomolar affinity
Francesc Albert Esteve-Turrillas,   Josep Vicent Mercader,   Consuelo Agulló,   Antonio Abad-Somovilla and   Antonio Abad-Fuentes  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00228D

Exploring the spectroscopic differences of Caki-2 cells progressing through the cell cycle while proliferating in vitro
M. Jimenez-Hernandez, C. Hughes, P. Bassan, F. Ball, M. D. Brown, N. W. Clarke and   P. Gardner
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00507K

A microfluidic anti-Factor Xa assay device for point of care monitoring of anticoagulation therapy
Leanne F. Harris, Paul Rainey, Vanessa Castro-López, James S. O’Donnell and   Anthony J. Killard
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00401E