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HOT articles in Analyst

29 Jan 2015

Take a look at our most recent HOT Analyst articles, these are now free to access for the next few weeks!

Label-free phenotyping of peripheral blood lymphocytes by infrared imaging
M. Verdonck, S. Garaud, H. Duvillier, K. Willard-Gallo and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01855A

Graphical Abstract

PNGase F-mediated incorporation of 18O into glycans for relative glycan quantitation
Wei Zhang, Weiqian Cao, Jiangming Huang, Hong Wang, Ji Wang, Chen Xie and Pengyuan Yang
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02073A

A microelectrochemical biosensor for real-time in vivo monitoring of brain extracellular choline
Keeley L. Baker, Fiachra B. Bolger and John P. Lowry
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02027H

Differentiation of Prostate Cancer from Normal Tissue in Radical Prostatectomy Specimens by Desorption Electrospray Ionization and Touch Spray Ionization Mass Spectrometry
K. S. Kerian, A. K. Jarmusch, V. Pirro, M. O. Koch, T. A. Masterson, L. Cheng and R. G. Cooks
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02039A

Multi-enzyme microreactor-based online electrochemical system for selective and continuous monitoring of acetylcholine
Yuqing Lin, Ping Yu and Lanqun Mao
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02089H

Fluorescence Chemosensors for Hydrogen Sulfide Detection in Biological Systems
Zhi Guo, Guiqiu Chen, Guangming Zeng, Zhongwu Li, Anwei Chen, Jiajia Wang and Longbo Jiang
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01909A

Marker-free automated histopathological annotation of lung tumour subtypes by FTIR-Imaging
Frederik Großerueschkamp, Angela Kallenbach-Thieltges, Thomas Behrens, Thomas Brüning, Matthias Altmayer, Georgios Stamatis, Dirk Theegarten and Klaus Gerwert
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01978D

Universal Electronics for Miniature and Automated Chemical Assays
Pawel L. Urban
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02013H

Graphical Abstract

Raman microimaging of murine lungs: insight into the vitamin A content
K. M. Marzec, K. Kochan, A. Fedorowicz, A. Jasztal, K. Chruszcz-Lipska, J. Cz. Dobrowolski, S. Chlopicki and M. Baranska
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01881H

Stereospecific recognition and quantitative structure-activity relationship between antibodies and enantiomers: ofloxacin as model hapten
Hongtao Mu, Baoling Wang, Zhenlin Xu, Yuanming Sun, Xinan Huang, Yudong Shen, Sergei A. Eremin, Anatoly V. Zherdev, Boris B. Dzantiev and Hongtao Lei
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02155J

A colorimetric method of analysis for trace amounts of hydrogen peroxide with the use of the nano–properties of Molybdenum disulfide
Xinrong Guo, Yong Wang, Fangying Wu, Yongnian Ni and Serge Kokot
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01950D

Infrared spectral signature of human lymphocyte subpopulations from peripheral blood
N. Wald, A. Legat, C. Meyer, D. E. Speiser and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02247E

Screening and mapping pigments in paintings using scanning electrochemical microscopy (SECM)
Antonio Doménech-Carbó, María Teresa Doménech-Carbó, Miguel Silva, Francisco Manuel Valle-Algarra, José Vicente Gimeno-Adelantado, Francisco Bosch-Reig and Rufino Mateo-Castro
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01911C

Transmission versus transflection mode in FTIR analysis of blood plasma: is the EFSW effect the only reason of the observed spectral distortions?
Emilia Staniszewska-Slezak, Anna Rygula, Kamilla Malek and Malgorzata Baranska
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01842G

Multivariate statistical methodologies applied in biomedical Raman spectroscopy: Assessing the validity of partial least squares regression using simulated model datasets.
Mark E. Keating, Haq Nawaz, Franck Bonnier and Hugh J. Byrne
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02167C

A colorimetric nitrite detection system based on Ag@Au nanoparticles with excellent selectivity and high sensitivity
Tianhua Li, Yonglong Li, Yujie Zhang, Chen Dong, Zheyu Shen and Aiguo Wu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01583E

Flow-through polymerase chain reaction inside a seamless 3D helical microreactor fabricated utilizing a silicone tube and a paraffin mold
Wenming Wu, Kieu The Loan Trinh and Nae Yoon Lee
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01675K

Graphical Abstract

ß-Cyclodextrin functionalised gold nanoclusters as a luminescent probe for the ultrasensitive detection of dopamine
Rui Ban, E. S. Abdel-Halim, Jianrong Zhang and Jun-Jie Zhu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02161D

In-vivo and continuous measurement of bisulfide in the hippocampus of rat’s brain by on-line integrated microdialysis/droplet-based microfluidic system
Feidan Gu, Xiaoyu Zhou, Xiaocui Zhu, Meiping Zhao, Jie Hao, Ping Yu and Lanqun Mao
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01974A, Paper

Infrared imaging of MDA-MB-231 breast cancer cell line phenotypes in 2D and 3D cultures
Margarita Smolina and Erik Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01833H

High throughput absorbance spectra of cancerous cells: a microscopic investigation of spectral artifacts
A. Mignolet and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01834F

Label-free imaging and identification of typical cells of acute myeloid leukaemia and myelodysplastic syndrome by Raman microspectroscopy
R. Vanna, P. Ronchi, A. T. M. Lenferink, C. Tresoldi, C. Morasso, D. Mehn, M. Bedoni, S. Picciolini, L. W. M. M. Terstappen, F. Ciceri, C. Otto and F. Gramatica
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02127D

Infrared imaging of primary melanoma reveals hints of regional and distant metastases
N. Wald and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01831A

Pituitary gland under infrared light – in search of a representative spectrum for homogenous regions
A. Banas, K. Banas, A. Furgal-Borzych, W. M. Kwiatek, B. Pawlicki and M. B. H. Breese
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01985G

Design of molecularly imprinted conducting polymer protein-sensing films via substrate-dopant binding
Elena Komarova, Matt Aldissi and Anastasia Bogomolova
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01965B

Vibrational signatures to discriminate liver steatosis grades
Chengyuan Peng, Franck Chiappini, Slávka Kaščáková, Mélanie Danulot, Christophe Sandt, Didier Samuel, Paul Dumas, Catherine Guettier and François Le Naour
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01679C

Graphical Abstract Competitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy
A. Maguire, I. Vega-Carrascal, J. Bryant, L. White, O. Howe, F. M. Lyng and A. D. Meade
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01887G

Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson’s disease
Michele Morari and Martina Fantin
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01918K

Infrared Micro-spectroscopy for Cyto-pathological Classification of Esophageal Cells
Douglas Townsend, Miloš Miljković, Benjamin Bird, Kathleen Lenau, Oliver Old, Max Almond, Catherine Kendall, Gavin Lloyd, Neil Shepherd, Hugh Barr, Nick Stone and Max Diem
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01884B

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Infrared offers odds on skin cancer spreading

13 Jan 2015

Scientists in Belgium have shown that infrared spectrometry can help predict how likely it is that a melanoma tumour, the deadliest and most common form of skin cancer, has spread to other organs.

Tumour spread, or metastasis, is the main threat to survival in melanoma patients. However, no biomarkers have been identified to indicate a high risk of metastasis and visual assessment of primary tumours by a trained pathologist is unlikely to reveal if cancerous cells have escaped to other parts of the body.

Graphical Abstract

Read the full article in Chemistry World

Infrared imaging of primary melanoma reveals hints of regional and distant metastases
N. Wald and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01831A

Do you fancy submitting an article to Analyst? Why not submit to us here today or alternatively email us with your suggestions!

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Analytical Science Twitter Poster Conference

19 Dec 2014

We are delighted to announce the Analytical Science Twitter Poster Conference (#RSCAnalyticalPoster) will be happening February 5 to February 6 2015!

An image to advertise the twitter conference of Analyst JAAS Analytical Methods

The Royal Society of Chemistry Analytical Science Twitter Poster Conference is an online event being held entirely over Twitter to bring members of the analytical research community together to share their research, network and engage in scientific debate.

How do I take part?

During the event simply tweet an image (e.g. JPEG) which will be a digital poster summarising your research along with #RSCAnalyticalPoster and the title of your work. Throughout the day you can then answer any questions posed to you by other people on Twitter and ask questions about other posters. Make sure you follow #RSCAnalyticalPoster throughout the day as the conference progresses.

When is it?

Posters tweeted with #RSCAnalyticalPoster between 9am GMT February 5 and 9am GMT February 6 will be eligible to win an i-pod or RSC book vouchers. Make sure you ask and answer lots of questions to ensure your work is well understood!

Is my research area suitable?

The conference is open to anyone working in any area of analytical science whose research topic is in the scope of Analyst, Analytical Methods or JAAS. If you’re unsure if your poster is suitable for the conference, just get in touch and we can advise.

What can I win?

The main aim of the event is to meet new scientists, share ideas and learn about the latest developments in different areas of analytical science. The scientific committee will also select 3 posters which stimulate wide interest and feature innovative, high quality, exciting analytical research. The top prize will be an i-pod and 2 runners-up will receive a £100 book voucher for the Royal Society of Chemistry Book Shop. Do make sure you also ask lots of questions, meet new people and share your thoughts and ideas about other posters and topics.

Who is organising the event and how do I find them?

At different points throughout the day members of the scientific committee will be logging in to Twitter and searching for #RSCAnalyticalPoster to ask questions about some of the posters. Make sure you check back in at different times to see if you have any new questions and also make sure you ask questions about other posters. Members of the scientific committee and their Twitter names are listed below and make sure you follow us @analystrsc @MethodsRSC and @JAASNews for the latest updates.

Chair and Organisers

Matt Baker, University of Strathclyde, UK @ChemistryBaker

Royal Society of Chemistry

Analyst @analystrsc, Analytical Methods @MethodsRSC and JAAS @JAASNews

Scientific Committee

Carsten Engelhard, Universität Siegen @EngelhrC

Craig Banks, Manchester Metropolitan University @Act_mmu

Damien Arrigan, Curtin University @arri_aus

Jean-Francois Masson, University of Montreal @Masson_chem

Karen Faulds, University of Strathclyde @FauldsKaren

Martin Resano, University of Zaragoza @MartinResano

Nick Stone, University of Exeter @profnickstone

Perdita Barran, The University of Manchester @PerditaB

Raychelle Burks, Doane College @DrRubidium

Renee JiJi, University of Missouri @ReneeJiJi

Richard Dluhy, University of Georgia @radluhy

Roy Goodacre, The University of Manchester @RoyGoodacre

How do I register?

Pre-registration is not necessary; however we will need to verify who you are and where you do your research to be eligible for the prizes. We strongly recommend you do this before the event by emailing us at and letting us know:

Your name, address and contact details

The title or topic of your poster

Your twitter ID

We look forward to meeting you in February!

Frequently Asked Questions (will be regularly updated)

Do I need to check the copyright and permissions needed for figures or any other parts of my poster which have already been published?
Yes. Copyright owners have the exclusive right to copy their work and to issue copies of their work to the public, and it is an infringement for anyone else to do so without the copyright owner’s permission. If you are reproducing material contained in a Royal Society of Chemistry publication (journal articles, book or book chapters) you may do so providing that you fully acknowledge the original Royal Society of Chemistry publication and include a link back to it. If you wish to include material that has been published by another publisher, you will need to check how the publisher/copyright owner of the third party material wishes to receive permission requests. Information on this can be found on our Permission Requests page at http://www.rsc.org/Publishing/copyright/permission-requests.asp under “Use of third party material in our publications”.

If I include unpublished work in my poster, will I still be able to publish this in a peer-reviewed journal afterwards?
Subject to the usual conditions outlined in the Licence to Publish, being a part of the Twitter conference will not prevent you using some of the information included in your poster as part of an article in a Royal Society of Chemistry journal. Please note this policy varies by publisher and if you intend to submit your research for publication elsewhere after the event, you should check the individual policy for that journal and publisher.

What size should my poster be?
You can choose any dimensions for your poster, the important thing is that the text and figures are clear for people to read and understand. Using Microsoft PowerPoint, we found a text size of between 12-16 were clear to read when saving an A4 slide as a JPEG and uploading to Twitter. Using an A0 template, the text needed to be between 50 and 60 to be legible. You can use any software you like to create your poster, as long as the image you upload is clear for others to read. We recommend testing your poster on Twitter before the conference to make sure you are happy with your image.

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HOT articles in Analyst

17 Dec 2014

Take a look at our most recent HOT Analyst articles, these are now free to access for the next few weeks!

Graphical Abstract

The breakthrough curve combination for xenon sampling dynamic in a carbon molecular sieve column
Liu Shu-jiang, Chen Zhan-ying, Chang Yin-zhong, Wang Shi-lian, Li Qi, Fan Yuan-qing, Jia Huai-mao, Zhang Xin-jun and Zhao Yun-gang
Analyst, 2015,140, 428-433
DOI: 10.1039/C4AN01766H

A WS2 nanosheet-based platform for fluorescent DNA detection via PNA-DNA hybridization
Shuting Wang, Yulin Zhang, Yong Ning and Guo-Jun Zhang
Analyst, 2015,140, 434-439
DOI: 10.1039/C4AN01738B

Hierarchically Assembled NiCo@SiO2@Ag Magnetic Core-Shell Microspheres as Highly Efficient and Recyclable 3D SERS Substrates
Maofeng Zhang, Aiwu Zhao, Dapeng Wang and Henghui Sun
Analyst, 2015,140, 440-448
DOI: 10.1039/C4AN01275E

A Microfluidic Interface for the Culture and Sampling of Adiponectin from Primary Adipocytes
Leah A. Godwin, Jessica C. Brooks, Lauren D. Hoepfner, Desiree Wanders, Robert L. Judd and Christopher J. Easley
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01725K

Enzymatic-Reaction Induced Production of Polydopamine Nanoparticles for Sensitive and Visual Sensing of Urea
Nan Li, Hai-Bo Wang, Larissa Thia, Jing-Yuan Wang and Xin Wang
Analyst, 2015,140, 449-455
DOI: 10.1039/C4AN01900H
Graphical Abstract

Bladder cancer biomarker array to detect aberrant levels of proteins in urine
S. Gogalic, U. Sauer, S. Doppler and C. Preininger
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01432D

Ratiometric Fluorescence Detection of Cysteine and Homocysteine with a BODIPY Dye by Mimicking the Native Chemical Ligation
Dong Hee Ma, Dokyoung Kim, Eunseok Seo, Sang-Joon Lee and Kyo Han Ahn
Analyst, 2015,140, 422-427
DOI: 10.1039/C4AN01791A

Glucose-Sensitive Nanofiber Scaffolds with Improved Sensing Design for Physiological Conditions
Mary K. Balaconis, Yi Luo and Heather A. Clark
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01775G

A Preliminary Raman spectroscopic study of Urine: Diagnosis of breast cancer in animal models
T. Bhattacharjee, A. Khan, G. Maru, A. Ingle and C. Murali Krishna
Analyst, 2015,140, 456-466
DOI: 10.1039/C4AN01703J

Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl-leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS
Ling Hao, Xuefei Zhong, Tyler Greer, Hui Ye and Lingjun Li
Analyst, 2015,140, 467-475
DOI: 10.1039/C4AN01582G

Review on Ion Mobility Spectrometry. Part 2: hyphenated methods and effects of experimental parameters
R. Cumeras, E. Figueras, C. E. Davis, J. I. Baumbach and I. Gràcia
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01101E

High finesse optical cavity coupled with a quartz-enhanced photoacoustic spectroscopic sensor
Pietro Patimisco, Simone Borri, Iacopo Galli, Davide Mazzotti, Giovanni Giusfredi, Naota Akikusa, Masamichi Yamanishi, Gaetano Scamarcio, Paolo De Natale and Vincenzo Spagnolo
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01158A
Graphical Abstract

Highly sensitive colorimetric detection of HgII and CuII in aqueous solution:From amino acids toward solid platforms
Jooyoung Park, Byunggyu In, Lok Nath Neupane and Keun-Hyeung Lee
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01743A

Ion Creation, Ion Focusing, Ion/Molecule Reactions, Ion Separation, and Ion Detection in the Open Air in a Small Plastic Device
Zane Baird, Pu Wei and R. Graham Cooks
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01929F

Comparison of FTIR transmission and transflection substrates for canine liver cancer detection
Kamila Kochan, Philip Heraud, Matti Kiupel, Vilma Yuzbasiyan-Gurkan, Don McNaughton, Malgorzata Baranska and Bayden R. Wood
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01901F

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Seeing glucose through the skin

05 Dec 2014

Graphical Abstract Scientists in Germany have developed a spectroscopy method to measure diabetics’ glucose levels through their skin.

When a sample is irradiated with IR light, it produces a temperature increase and when this heat diffuses to a material in contact with the sample, a temperature gradient is created, causing a thermal lens – just like the mirage effect you see in the air on the surface of a hot road. By examining the deflection of a probe beam across this lens, you can study the thermal and optical properties of the sample.

Read the full article in Chemistry World

Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis
M.A.Pleitez, O.Hertzberg, A.Bauer, M.Seeger, T.Lieblein, H.v.Lilienfeld-Toalb and W.Mäntelea
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01185F

Do you fancy submitting an article to Analyst? Why not submit to us here today or alternatively email us with your suggestions!

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HOT articles in Analyst

26 Nov 2014

Take a look at our most recent HOT Analyst articles, these are now free to access for the next few weeks!

Propofol Detection and Quantification in Human Blood: The Promise of Feedback Controlled, Closed-loop Anesthesia
Francine Kivlehan, Edward Chaum and Erno Lindner
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01483A

Graphical Abstract
Direct Analysis of in-Gel Proteins by Carbon Nanotubes-Modified Paper Spray Ambient Mass Spectrometry
Feifei Han, Yuhan Yang, Jin Ouyang and Na Na
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01688B

Responsive Ionic Liquid-Polymer 2D Photonic Crystal Gas Sensors
Natasha L. Smith, Zhenmin Hong and Sanford A. Asher
Analyst, 2014, 139, 6379-6386
DOI: 10.1039/C4AN01485E

Label-Free Fluorescence Detection of DNA Methylation and Methyltransferase Activity Based on Restriction Endonuclease HpaII and Exonuclease III
Chunyan Gao, Henan Li, Yuanjian Liu, Wei Wei, Yuanjian Zhang and Songqin Liu
Analyst, 2014, 139, 6387-6392
DOI: 10.1039/C4AN01359J

Autocatalytic Amplified Detection of DNA Based on CdSe Quantum Dots/Folic Acid Electrochemiluminescence Energy Transfer System
Guifen Jie, Yingqiang Qin, Qingmin Meng and Jialin Wang
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01465K

Carbon nanotube/gold nanoparticle composite–coated membrane as a facile plasmon–enhanced interface for sensitive SERS sensing
Kun Zhang, Ji Ji, Xiaoni Fang, Ling Yan and Baohong Liu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01473A

Graphical Abstract
UV Photodissociation of trapped ions following ion mobility separation in a Q-ToF mass spectrometer
Bruno Bellina, Jeffery. M. Brown, Jakub Ujma, Paul Murray, Kevin Giles, Michael Morris, Isabelle Compagnon and Perdita. E. Barran
Analyst, 2014, 139, 6348-6351
DOI: 10.1039/C4AN01656D

Oligopeptide-heavy metal interaction monitoring by hybrid gold nanoparticles based assay
Jane Politi, Jolanda Spadavecchia, Mario Iodice and Luca de Stefano
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01491J

Hydrazinonicotinic acid as a novel matrix for highly sensitive and selective MALDI-MS analysis of oligosaccharides
Jing Jiao, Ying Zhang, Pengyuan Yang and Haojie Lu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01659A

Development of Transmission Raman Spectroscopy towards the In Line, High Throughput and Non-Destructive Quantitative Analysis of Pharmaceutical Solid Oral Dose
Julia A. Griffen, Andrew W. Owen and Pavel Matousek
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01798F

An adaptable stage perfusion incubator for the controlled cultivation of C2C12 myoblast cells
Felix Kurth, Alfredo Franco-Obregón, Christoph A. Bärtschi and Petra. S. Dittrich
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01758G

Surface Charge, Electroosmotic Flow and DNA Extension in Chemically Modified Thermoplastic Nanoslits and Nanochannels
Franklin I. Uba, Swathi R. Pullagurla, Nichanun Sirasunthorn, Jiahao Wu, Sunggook Park, Rattikan Chantiwas, Yoon-Kyoung Cho, Heungjoo Shin and Steven A. Soper
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01439A

Graphical Abstract
A Pressure-Driven Capillary Electrophoretic System with Injection Valve Sampling
Chao Han, Jiannan Sun, Jinhua Liu, Heyong Cheng and Yuanchao Wang
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01315H

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity
Amelie Fiene, Younis Baqi, Joanna Lecka, Jean Sévigny and Christa E. Müller
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01694G

The “V-junction”: a novel structure for high-speed generation of bespoke droplet flows
Yun Ding, Xavier Casadevall i Solvas and Andrew deMello
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01730G

Make PyrophosphateVisible: The First Precipitable and Real-time Fluorescent Sensor for Pyrophosphate in Aqueous Solution
Shu-Yan Jiao, Kun Li, Xin Wang, Zeng Huang, Lin Pu and Xiao-Qi Yu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01615G

Constructing a FRET-based molecular chemodosimeter for cysteine over homocysteine and glutathione by naphthalimide and phenazine derivatives
Lin Yang, Weisong Qu, Xiao Zhang, Yandi Hang and Jianli Hua
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01732C

High pH sensing with water-soluble porpholactone derivatives and their incorporation into a Nafion® optode membrane
Jill L. Worlinsky, Steven Halepas, Masoud Ghandehari, Gamal Khalil and Christian Brückner
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01462F

Graphical Abstract
Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis
M. A. Pleitez, O. Hertzberg, A. Bauer, M. Seeger, T. Lieblein, H. v. Lilienfeld-Toal and W. Mäntele
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01185F

Exploring Copper Nanostructures as highly uniform and reproducible substrates for Plasmon-enhanced Fluorescence
D. Volpati, E. R. Spada, C. C. Plá Cid, M. L. Sartorelli, R. F. Aroca and C. J. L. Constantino
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN00889H

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Ultrasensitive peanut allergy test

13 Nov 2014

Graphical Abstract

Scientists in the US have developed an ultrasensitive procedure for spotting anti-peanut antibodies in blood.

Peanut allergies are recognised as one of the most serious food allergies, sometimes being fatal, and the severity of one’s allergy can change or develop over time. Diagnosis tends to combine medical history with clinical assays but often fails to indicate how severe an allergy is.

James Rusling, from the University of Connecticut, and colleagues, hope to develop their immunoarray into a system that diagnoses the severity of a patient’s peanut allergy. Their surface plasmon resonance (SPR) array is the first of its kind to record measurements using both carbohydrate and peptide epitopes from glycoprotein Arachis hypogaes h2 (Ara-h2). Ara-h2 is the most potent allergen from the Arachis hypogaes family, the major peanut allergens for sufferers. UUUTEHRTH

Read the full article in Chemistry world

Ultrasensitive carbohydrate-peptide SPR imaging microarray for diagnosing IgE mediated peanut allergy
Amit A. Joshi, Mark W. Peczuh, Challa V. Kumar and James F. Rusling
Analyst, 2014,139, 5728-5733
DOI: 10.1039/C4AN01544D

Do you fancy submitting an article to Analyst? Why not submit to us here today or alternatively email us with your suggestions!

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HOT articles in Analyst

30 Oct 2014

Take a look at our recent HOT Analyst articles, these are now free to access for the next few weeks!

A Smart Ink for the Assessment of Low Activity Photocatalytic Surfaces
Andrew Mills, Christopher O’Rourke and Nathan Wells
Analyst, 2014, 139, 5409-5414
DOI: 10.1039/C4AN01375A

Graphical Abstract

Screen-Printed Back-to-Back Electroanalytical Sensors
Jonathan P. Metters, Edward P. Randviir and Craig E. Banks
Analyst, 2014, 139, 5339-5349
DOI: 10.1039/C4AN01501K

Fabrication and laser patterning of polystyrene optical oxygen sensor films for lab-on-a-chip applications
S. M. Grist, N. Oyunerdene, J. Flueckiger, J. Kim, P. C. Wong, L. Chrostowski and K. C. Cheung
Analyst, 2014, 139, 5718-5727
DOI: 10.1039/C4AN00765D

Reactive intermediate detection in real time via paper assisted thermal ionization mass spectrometry
Jiying Pei, Yanbiao Kang and Guangming Huang
Analyst, 2014, 139, 5354-5357
DOI: 10.1039/C4AN01343C

DNA Bioassay-on-Chip using SERS Detection for Dengue Diagnosis
Hoan T. Ngo, Hsin-Neng Wang, Andrew M. Fales, Bradly P. Nicholson, Christopher W. Woods and Tuan Vo-Dinh
Analyst, 2014, 139, 5655-5659
DOI: 10.1039/C4AN01077A

Aptasensor for potassium based on RecJf exonuclease mediated signal amplification
Peng Miao, Yuguo Tang, Bidou Wang, Kun Han, Xifeng Chen and Haixuan Sun
Analyst, 2014, 139, 5695-5699
DOI: 10.1039/C4AN01350F

Rapid, Highly Sensitive Detection of Herpes Simplex Virus-1 using Multiple Antigenic Peptide-Coated Superparamagnetic Beads
Ying-Fen Ran, Conor Fields, Julien Muzard, Viktoryia Liauchuk, Michael Carr, William Hall and Gil U. Lee
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00774C

New algorithm for identification of components in a mixture: application to Raman spectra of solid amino acids
Sylwester Gawinkowski, Agnieszka Kaminska, Tomasz Rolinski and Jacek Waluk
Analyst, 2014, 139, 5755-5764
DOI: 10.1039/C4AN01159G

Cold neutron diffraction contrast tomography of polycrystalline material
S. Peetermans, A. King, W. Ludwig, P. Reischig and E. H. Lehmann
Analyst, 2014, 139, 5765-5771
DOI: 10.1039/C4AN01490A

Tailoring recognition clefts from non-specific recognition matrices in mixed molecular arrays
Nivarthi Ramesh and Archita Patnaik
Analyst, 2014, 139, 5772-5780
DOI: 10.1039/C4AN01120A

Graphical Abstract

Glyconanoparticles for colorimetric bioassays
María J. Marín, Claire L. Schofield, Robert A. Field and David A. Russell
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01466A

Nanocoax for Optical and Electronic Devices
Binod Rizal, Juan M. Merlo, Michael J. Burns, Thomas C. Chiles and Michael J. Naughton
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01447B

3D printed metal columns for capillary liquid chromatography
S. Sandron, B. Heery, V. Gupta, D. A. Collins, E. P. Nesterenko, P. N. Nesterenko, M. Talebi, S. Beirne, F. Thompson, G. G. Wallace, D. Brabazon, F. Regan and B. Paull
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01476F

Droplet microfluidics in (bio) chemical analysis
Evgenia Yu Basova and Frantisek Foret
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01209G

A TEM protocol for quality assurance of in vitro cellular barrier models and its application to the assessment of nanoparticle transport mechanisms across barriers
Dong Ye, Kenneth A. Dawson and Iseult Lynch
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01276C

A novel molecularly imprinted chitosan-acrylamide, graphene, ferrocene composite cryogel biosensor used to detect microalbumin
Amin Fatoni, Apon Numnuam, Proespichaya Kanatharana, Warakorn Limbut and Panote Thavarungkul
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01000K

Rapid identification of synthetic colorants in food samples by using indium oxide nanoparticle-functionalized porous polymer monolith coupled with HPLC-MS/MS
Ruifang Qi, Xiao Zhou, Xiqian Li, Jiutong Ma, Chunmei Lu, Jun Mu, Xuguang Zhang and Qiong Jia
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01392A

Graphical Abstract

HPLC-MRM Relative Quantification Analysis of Fatty Acids Based on a Novel Derivatization Strategy
Tie Cai,Hu Ting, Zhang Xin-Xiang, Zhou Jiangb and Zhang Jin-Lan
Analyst, 2014, 139, 6154-6159
DOI: 10.1039/C4AN01314J

Multimodal Optical Characterisation of Collagen Photodegradation by Femtosecond Infrared Laser Ablation
A. Manickavasagam, L. M. Hirvonen, L. N. Melita, E. Z. Chong, R. J. Cook, L. Bozecc and F. Festy
Analyst, 2014, 139, 6135-6143
DOI: 10.1039/C4AN01523A

Ion Collision Cross Section Measurements in Quadrupole Ion Traps Using a Time-frequency Analysis Method
Muyi He, Dan Guo, Yu Chen, Xingchuang Xiong, Xiang Fangc and Wei Xu
Analyst, 2014, 139, 6144-6153
DOI: 10.1039/C4AN01216J

Label-Free Detection of DNA by Combining Gated Mesoporous Silica and Catalytic Signal Amplification of Platinum Nanoparticle
Zhifei Wang, Xia Yang, Jie Feng, Yongjun Tang, Yanyun Jianga and Nongyue He
Analyst, 2014, 139, 6088-6091
DOI: 10.1039/C4AN01539H

Molecular phenotypic profiling of a Saccharomyces cerevisiae strain at the single-cell level
A. Mareike Schmidt, Stephan R. Fagerer, Konstantins Jefimovs, Florian Buettner, Christian Marro, Erdem C. Siringil, Karl L. Boehlen, Martin Pabstb and Alfredo J. Ibáñez
Analyst, 2014, 139, 5709-5717
DOI: 10.1039/C4AN01119H

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New test accelerates herpes detection

22 Oct 2014

A new assay for spotting the virus responsible for cold sores has been developed by scientists in Ireland.

Graphical Abstract

It is estimated that between 60–95% of adults worldwide are infected with the herpes simplex virus-1 (HSV-1) and although the symptoms are usually limited to sores or blisters, in rare cases it can infect the central nervous system, which is fatal in 70% of untreated cases. If diagnosed early, antiviral therapy can lead to a positive outcome, thus emphasising the need for rapid diagnostic methods.

Interested to know more? Read the full article in Chemistry World here…

Rapid, highly sensitive detection of herpes simplex virus-1 using multiple antigenic peptide-coated superparamagnetic beads
Ying-Fen Ran, Conor Fields, Julien Muzard, Viktoryia Liauchuk, Michael Carr, William Hall and Gil U. Lee
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00774C, Paper

Do you fancy submitting an article to Analyst? Why not submit to us here today or alternatively email us with your suggestions!

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SPEC 2014

25 Sep 2014

The International conference, SPEC 2014: Shedding New Light on Disease, was held on the 17th – 22nd August in Krakow, Poland. The conference was Co-chaired by Prof. Malgorzata Baranska, Jagellonian University, Krakow, Poland, Prof. Hugh J. Byrne, Dublin Institute of Technology, Ireland, and Prof. Anna Sulkowska, Medical University of Silesia, Katowice, Poland.

The event was the 8th in the series of biennial conferences, the aim of which is to bring together clinicians and scientists who have joined forces in the quest for novel biomedical applications of Infrared and Raman spectroscopy to improve patient care. Recent advances in the biological sciences and medicine have led to an increasing demand for real time and minimally invasive chemical and structural informa¬tion on biological materials. Due to its unique fingerprinting capability, vibrational spectroscopy plays a significant role in histopathology, cytology, biopsy targeting, surgical targets, treatment monitoring and drug studies.

The conference aimed to highlight further advances in state of the art and emerging biomedical applications of Vibrational Spectroscopy framed under the themes of:

Translational research into in vivo clinical applications

Ex vivo tissue biopsies, body fluids and cytological samples for diagnostics and disease studies

In vitro cell culture and 3D models for Research and Medical applications

while reviewing the challenges in the context of other emerging technologies. The programme was constructed in an attempt to prioritise real world applications from the outset, systematically progressing from research towards in vivo, ex vivo and in vitro applications, as well as emerging technologies and data processing, and featured Plenary, Invited and Contributed presentations in each session. The Flash Presentation session provided an opportunity for Early Stage Researchers to orally summarise their poster presentations to the audience in a one minute pitch on the Monday evening (18th), in advance of the formal poster session, on the Tuesday (19th). The Renishaw prize for Best Flash presentation was awarded to Helena Ukkonen, for her presentation entitled “FTIR Imaging Identifies the Changes in the Tumor Microenvironment Caused by Different Cancer Cells”.

Prof. Hugh J. Byrne presents the Analyst prize for best poster presentation to Niels Kröger, Heidelberg University, Germany

Niels Kröger, Heidelberg University, Germany, was awarded the Analyst Poster Prize for his presentation on “Rapid Hyperspectral Imaging of Biological Tissue Using Quantum Cascade Lasers”, while best poster prizes were also awarded to Elisa Barroso and Roeland Smits, Erasmus University Medical Center Rotterdam, for the presentation “High-Wavenumber Raman Spectroscopy to Discriminate Squamous Cell Carcinoma From Healthy Tissue Based on Water Content” sponsored by WITec, and Mohamed Abu Ayoobul Ansary, Jagiellonian University, Poland, for the presentation “Optimization of conjugation of Au/Ag-core/shell nanoparticles with antibodies for SERS studies on endothelial cells” sponsored by Bruker.

A feature of the conference was the daily discussion sessions which were aimed at a critical assessment of the routes towards the further development of clinical applications, under the heading “Quo Vadis? Spectropathology for the next generation” and were moderated by members of the SPEC International Advisory Board. The discussions, based around the three themes above, were loosely based on the agreed framework of:

(i)       What are the most achievable, strategic target applications
(ii)      What are the technical challenges, and how can they be addressed
(iii)     What are the challenges to implementation (legislative, clinical trials etc.), and how can they be addressed

The deliberations of the discussion groups will contribute to a “Roadmap” paper in the special edition of international peer reviewed journal, Analyst, co-authored by the IAB moderators. The discussion sessions also enabled outline presentations of the UK EPSRC CLIRSPEC (Clinical Infrared and Raman Spectroscopy for Medical Diagnosis) and the EU COST network Raman4clinics (European Network on Raman-based applications for clinical diagnostics) and their respective workprogrammes to promote and progress the translation of vibrational spectroscopic technologies into the clinical environment.

Prof. Peter Gardner (Uni. Of Manchester), addresses the Gala Dinner on behalf of the SPEC International Advisory Board, outlining proposals for the establishment of the International Clinical Spectroscopy Society.

The programme and discussions clearly demonstrated that there has been much progress in the understanding of the complexity of spectroscopic characterisation of biological materials, and data preprocessing and postprocessing methods can be applied with confidence to give true biochemical representations of tissue, cells and bodily fluids. Spectroscopic techniques remain a powerful tool for basic research and may find applications in vitro for toxicology and drug screening. Emerging technologies continue to push the performances in terms of acquisition speed, spatial resolution and multimodality. In terms of translation to a clinical environment, there remains a lack of standardisation of measurement and data analysis protocols ex vivo, while cost implications need also to be considered. The increased development of fibre probes shows great promise for in vivo intra-operative applications. However, the need to engage the medical community remains an imperative.

A significant outcome of the satellite meeting of the SPEC IAB was the agreement in principle to the establishment of an International Clinical Spectroscopy Society, as a not-for profit Private Company Limited by Guarantee with charitable status. The Society will primarily promote the translational of spectroscopy into the clinical environment to improve patient diagnosis and prognosis. The SPEC Conference Series will be the primary vehicle of the Society towards this goal. The IAB also accepted the proposal that the next in the series, SPEC 2016, will be held in Montreal, Canada.

The conference attracted 282 participants from 32 countries around the globe. The programme included 62 oral and 191 poster contributions. It was sponsored by a number of commercial enterprises and other organisations, including: Witec, Renishaw, Agilent Technologies, Bruker, NT-MDT, Art Photonics, Thermo-Scientific, Comef, Horiba Scientific, Bio-Tools, Photon Etc., London Spectroscopy, Analyst, CLIRSPEC, PAN, PAU, ABE, KNOW im. Smoluchowskiego, LOT Quantum Design.

The conference was held against the backdrop of the 650th anniversary celebrations of the Jagiellonian University, and enjoyed honorary patronage of the Jagiellonian University, the Mayor of the City of Krakow, the Malopolska Voivodeship and the Marshal of the Małopolska Voivodeship.

And remember, attendees of the SPEC 2014 conference are all invited to submit to the upcoming themed issue in Analyst: deadline 17th October, 2014
Contact us here for more information

Take a look at our previous SPEC themed issue; Optical Diagnosis

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