Scientists in the US have developed an ultrasensitive procedure for spotting anti-peanut antibodies in blood.
Peanut allergies are recognised as one of the most serious food allergies, sometimes being fatal, and the severity of one’s allergy can change or develop over time. Diagnosis tends to combine medical history with clinical assays but often fails to indicate how severe an allergy is.
James Rusling, from the University of Connecticut, and colleagues, hope to develop their immunoarray into a system that diagnoses the severity of a patient’s peanut allergy. Their surface plasmon resonance (SPR) array is the first of its kind to record measurements using both carbohydrate and peptide epitopes from glycoprotein Arachis hypogaes h2 (Ara-h2). Ara-h2 is the most potent allergen from the Arachis hypogaes family, the major peanut allergens for sufferers. UUUTEHRTH
Ultrasensitive carbohydrate-peptide SPR imaging microarray for diagnosing IgE mediated peanut allergy
Amit A. Joshi, Mark W. Peczuh, Challa V. Kumar and James F. Rusling
Analyst, 2014,139, 5728-5733