2012 – Page 5 – Analyst Blog

Archive for 2012

Point of Care Diagnostics Workshop – 4 Dec 2012, London UK

09 Oct 2012

Point-of-Care Diagnostics Workshop
4 December 2012, Burlington House, London, UK

Point-of-care diagnostic (POC) test devices provide rapid results on an ever expanding range of medical tests, helping to streamline healthcare and improve clinical outcomes. Research on microfluidics for POC applications has increased markedly in recent years, fuelled by an interest in constructing field-deployable analytical instruments. The interest in POC microfluidic-based devices has been intense and has cut across all major disciplines in lab-on-a-chip research, including engineering (biomedical, chemical, electrical, and mechanical), chemistry, and physics. For further details please visit the website.

Abstract submission deadline: 31 October 2012. Abstract submission is now available online.

Application deadline: 31 October 2012. Application is now available online.

Workshop format
The aims of this Joint Biochemical Society/Royal Society of Chemistry workshop are to provide participants with a better understanding of the challenges involved in translating research outputs into application and to help encourage collaborations with industry and clinicians on POC. The workshop will bring together researchers who work at the interface between biology, chemistry and the wider life and medical sciences. Participants will be encouraged to participate in oral presentations, as well as in discussion groups intended to help move this area forward.

Speakers
Dr Ana Alfirevic, University of Liverpool, UK
Professor Andrew de Mello, ETH Zürich, Switzerland

Attendance is by application only and will be FREE of charge for Biochemical Society and Royal Society of Chemistry members.

This workshop is the fourth of a series entitled “Analytical Tools for the Life Sciences”, a collaborative project between the Biochemical Society and Royal Society of Chemistry members.

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Mastering Big Ideas for Small Devices

08 Oct 2012

By Pui Sai Lau, Web Writer

Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis

Zenhausern et al., Analyst, 2012, Advance Article

Miniature. Fast. Automated. User-friendly. Low cost. These are characteristics that describe the ideal analytical device for many applications such as point-of-care diagnostics. Rapid advancement has been made in microfluidics and micro total analysis systems over the past twenty years, which has resulted in substantial improvements to common procedures like PCR analysis. Frederic Zenhausern and colleagues from the University of Arizona, USA, have made further progress by optimizing the efficiency of multiplexed PCR on an microfluidic device to yield high-quality DNA analysis. Find out all the details by accessing the link below, it will be free to read until Oct 19th:

Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis
Matthew D. Estes, Jianing Yang, Brett Duane, Stan Smith, Carla Brooks, Alan Nordquist and Frederic Zenhausern
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35768B

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HOT articles in Analyst this September

03 Oct 2012

An cover Take a look below at some wonderful HOT articles we’ve recently published this month in Analyst. There are papers covering a large variety of fields, including metabolomics, sample preparation, fluorimetry and electrochemiluminescent sensing. These HOT papers will be free to read for two weeks.

Selective fluorometric detection of pyrophosphate by 3-hydroxyflavone-diphenyltin(IV) complex in aqueous micellar medium
Raul Villamil-Ramos , Víctor Barba and Anatoly K. Yatsimirsky
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35999E

Morphological analysis of vibrational hyperspectral imaging data
Jacob Filik , Abigail V. Rutter , Josep Sulé-Suso and Gianfelice Cinque
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35914F

Layer-by-layer self-assembled graphene oxide/silica microsphere composites as stationary phase for high performance liquid chromatography
Xiaojing Liang , Shujuan Liu , Xinwang Song , Yangwen Zhu and Shengxiang Jiang
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36091H

Intramolecular vibrational coupling in water molecules revealed by compatible multiple nonlinear vibrational spectroscopic measurements
Shuji Ye , Sulan Ma , Feng Wei and Hongchun Li
Analyst, 2012,137, 4981-4987
DOI: 10.1039/C2AN35684H

Fenton’s reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device
Li-Pei Zhang , Xiao-Xing Zhang , Bo Hu , Li-Ming Shen , Xu-Wei Chen and Jian-Hua Wang
Analyst, 2012,137, 4974-4980
DOI: 10.1039/C2AN36049G

Sensitive spectrofluorometry of cellular prion protein based on the on–off interaction between fluorescent dye-labelled aptamers and multi-walled carbon nanotubes
Lei Zhan , Li Peng , Yan Yu , Shu Jun Zhen and Cheng Zhi Huang
Analyst, 2012,137, 4968-4973
DOI: 10.1039/C2AN35924C

One-step immobilization of Ru(bpy)32+ in a silica matrix for the construction of a solid-state electrochemiluminescent sensor with high performance
Jing Li , Fang-Nan Xiao and Xing-Hua Xia
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35980D

Implementation of a semi-automated strategy for the annotation of metabolomic fingerprints generated by liquid chromatography-high resolution mass spectrometry from biological samples
Frédérique Courant , Anne-Lise Royer , Sylvain Chéreau , Marie-Line Morvan , Fabrice Monteau , Jean-Philippe Antignac and Bruno Le Bizec
Analyst, 2012,137, 4958-4967
DOI: 10.1039/C2AN35865D

An cover 2

Applications of reversible covalent chemistry in analytical sample preparation
David Siegel
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35697J

Tactile multisensing on flexible aluminum nitride
Simona Petroni , Francesco Guido , Bruno Torre , Andrea Falqui , Maria Teresa Todaro , Roberto Cingolani and Massimo De Vittorio
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36015B

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HOT articles in Issue 21 of Analyst

03 Oct 2012

It’s a bumper list of HOT articles that we have in this current issue of Analyst!

Outside front cover, Analyst, Issue 21, 2012

Chung et al., Analyst, 2012, 137, 4921

We have our cover article from Yu-Chang Tyan and Tze-Wen Chung and their study on a proposed a new approach for the detection of proteins to assess the response of fibroblasts to a material surface.

Assessing the responses of cellular proteins induced by hyaluronic acid-modified surfaces utilizing a mass spectrometry-based profiling system: Over-expression of CD36, CD44, CDK9, and PP2A
Ming-Hui Yang, Shiang-Bin Jong, Chi-Yu Lu, Yu-Fen Lin, Pei-Wen Chiang, Yu-Chang Tyan and Tze-Wen Chung
Analyst, 2012, 137, 4921-4933
DOI: 10.1039/C2AN35368G

We also have a number of exciting papers on a range of topics including

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Carlos Pérez-Campaña, Vanessa Gómez-Vallejo, Abraham Martin, Eneko San Sebastián, Sergio E. Moya, Torsten Reese, Ronald F. Ziolo and Jordi Llop
Analyst, 2012, 137, 4902-4906
DOI: 10.1039/C2AN35863H

Surface-enhanced Raman scattering-active gold nanoparticles modified with a monolayer of silver film
Chun-Chao Chang, Kuang-Hsuan Yang, Yu-Chuan Liu, Chung-Chin Yu and Yi-Hao Wu
Analyst, 2012, 137, 4943-4950
DOI: 10.1039/C2AN35912J

Llop et al., Analyst, 2012, 137, 4902

A simultaneous voltammetric temperature and humidity sensor
Linhongjia Xiong, Ai M. Fletcher, Stephen G. Davies, Sarah E. Norman, Christopher Hardacre and Richard G. Compton
Analyst, 2012, 137, 4951-4957
DOI: 10.1039/C2AN35939A

Implementation of a semi-automated strategy for the annotation of metabolomic fingerprints generated by liquid chromatography-high resolution mass spectrometry from biological samples
Frédérique Courant, Anne-Lise Royer, Sylvain Chéreau, Marie-Line Morvan, Fabrice Monteau, Jean-Philippe Antignac and Bruno Le Bizec
Analyst, 2012, 137, 4958-4967
DOI: 10.1039/C2AN35865D

Sensitive spectrofluorometry of cellular prion protein based on the on–off interaction between fluorescent dye-labelled aptamers and multi-walled carbon nanotubes
Lei Zhan, Li Peng, Yan Yu, Shu Jun Zhen and Cheng Zhi Huang
Analyst, 2012, 137, 4968-4973
DOI: 10.1039/C2AN35924C

Chen & Wang et al., Analyst, 2012, 137, 4974

Fenton’s reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device
Li-Pei Zhang, Xiao-Xing Zhang, Bo Hu, Li-Ming Shen, Xu-Wei Chen and Jian-Hua Wang
Analyst, 2012, 137, 4974-4980
DOI: 10.1039/C2AN36049G

Intramolecular vibrational coupling in water molecules revealed by compatible multiple nonlinear vibrational spectroscopic measurements
Shuji Ye, Sulan Ma, Feng Wei and Hongchun Li
Analyst, 2012, 137, 4981-4987
DOI: 10.1039/C2AN35684H

These HOT papers will be free to read until Oct 19th.

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Biological fate of nanoparticles in the body

03 Oct 2012

Metal oxide nanoparticles are currently used for a variety of applications including diagnostics and biomedicine. However, these nanoparticles are extremely difficult to detect and measure once they are distributed in a biological system. Now, Spanish scientists have developed a novel way for measuring their biodistribution.

Positron emission tomography image of the 18F-labelled metal oxide nanoparticles in vivo

Until now, labelling techniques have relied upon the functionalisation of the surface of the nanoparticle, which may alter the behaviour of the nanoparticle. Jordi Llop at the Centre for Cooperative Research in Biomaterials-CIC biomaGUNE, in San Sebastian, and co-workers, have developed a unique approach to avoid this by preparing metal oxides enriched with ¹⁸O. The ¹⁸O is incorporated to allow for more efficient cyclotron-mediated conversion to the radioactive ¹⁸F which can then be traced in vivo.

To read the full article please visit Chemistry World

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Carlos Pérez-Campaña , Vanessa Gómez-Vallejo , Abraham Martin , Eneko San Sebastián , Sergio E. Moya , Torsten Reese , Ronald F. Ziolo and Jordi Llop
Analyst, 2012,137, 4902-4906
DOI: 10.1039/C2AN35863H

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Seeing cells under stress

02 Oct 2012

An analytical platform that imposes controlled mechanical strain onto live cells whilst monitoring changes in cell morphology and molecular signalling has been developed by scientists in Germany. Cellular processes induced by mechanical forces are crucial for bone healing and lung function. Understanding these processes could help to prevent and aid the development of therapies for mechanically induced lung and cardiovascular diseases and injuries.

Christine Kranz and colleagues from the University of Ulm combined fluorescence microscopy with atomic force microscopy to analyse the cells. They integrated a motorised cell stretching device into the system. ‘We combined the stretching device with biosensor technology, enabling localised measurements of adenosine triphosphate (ATP), for example, which is among the most important signalling molecule associated with mechanical stress,’ says Kranz. ‘Consequently, detecting ATP at the surface of mechanically stimulated cells facilitates investigation of the signalling cascades involved.’

The assembly includes a cell-stretching device, an atomic force microscopy head and an objective of the inverted microscope

To read the full article please visit Chemistry World.

Combining atomic force-fluorescence microscopy with a stretching device for analyzing mechanotransduction processes in living cells
E. Hecht , P. Knittel , E. Felder , P. Dietl , B. Mizaikoff and C. Kranz
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36001B

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Analyst Issue 21 now online!

02 Oct 2012

The latest issue of Analyst is online with three cover articles for you to enjoy.

Chung et al., Analyst, 2012, 137, 4921

The very informative front cover comes from Yu-Chang Tyan and Tze-Wen Chung from the National Yunlin University of Science and Technology and Kaohsiung Medical University, respectively, and colleagues from Taiwan. In their study they proposed a new approach for the detection of proteins to assess the response of fibroblasts to a material surface. Biomaterials play an important role in regenerative medicine and drug delivery, therefore the interactions between biomaterial surfaces and cells are important to characterize cell proliferation, differentiation and regeneration of tissues.

Inside front cover, Analyst, Issue 21, 2012

Kaminskyj et al., Analyst, 2012, 137, 4934

We head to Canada for our inside front cover. Kathleen M. Gough and Susan G. W. Kaminskyj from the University of Manitoba and the University of Saskatchewan, together with colleagues have been studying the filamentous fungi Aspergillus. This fungi can can affect humans through their roles in biotechnology and recycling, and can also be responsible for disease.

What they have discovered is that Surface Enhanced Raman Scattering (SERS) can provide chemical information on materials that are in close contact with appropriate metal substrates, in this case nanopatterned gold surfaces and gold nanoparticles (AuNPs). They have created conditions for AuNP formation within and on the surface of Aspergillus nidulans hyphae in order to explore their potential for SERS analysis.

Proof-of-principle for SERS imaging of Aspergillus nidulans hyphae using in vivo synthesis of gold nanoparticles
Martin A. Prusinkiewicz, Fatemeh Farazkhorasani, James J. Dynes, Jian Wang, Kathleen M. Gough and Susan G. W. Kaminskyj
Analyst, 2012, 137, 4934-4942
DOI: 10.1039/C2AN35620A

Zhang et al., Analyst, 2012, 137, 4917

On the back cover of this month’s issue we showcase the work contributed by Weidong He, and Xiao Lin at the Vanderbilt Institute of Nanoscale Science and Technology, and the Institute of Physics, Chinese Academy of Sciences who together with colleagues have studied the analytical expression of Coulombic interaction between a nanorod and a nanoparticle.

The evaluation of Coulombic interaction in the oriented-attachment growth of colloidal nanorods
Weidong He, Junhao Lin, Xiao Lin, Ning Lu, Ming Zhou and Kelvin H. L. Zhang
Analyst, 2012, 137, 4917-4920
DOI: 10.1039/C2AN35950B

All of these papers will be free to access for 6 weeks. So why not click through and have a read.

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HOT Article: The future of clinical imaging, Electrical Impedance Tomography

02 Oct 2012

An Electrical Impedance Tomography scan of a human head

Richard Bayford and Andrew Tizzard, Analyst, 2012, 137, 4635

By Laura Ruvuna, Web Writer

In this HOT article, Richard Bayford and Andrew Tizzard at Middlesex University review the current progress of Electrical Impedance Tomography (EIT) in biological imaging. Unlike traditional imaging techniques, EIT does not use radiation and achieves a higher depth penetration, which is crucial for early disease detection.
EIT creates a map of a region based on the impedance of current through tissue, and the resulting measurements are processed through a series of algorithms to produce an image. Thus far, EIT has been utilized for a range of diseases including tumor imaging, cardiothoracic monitoring of blood clots, and studying areas of the brain in epilepsy. To read about additional applications of EIT, see more below. This paper will be free to read until Oct 15th.

Bioimpedance imaging: an overview of potential clinical applications
Richard Bayford and Andrew Tizzard
Analyst, 2012, 137, 4635-4643
DOI: 10.1039/C2AN35874C

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New RSC Gold subscribers have access to Analyst & Analytical Methods

01 Oct 2012

If your institution has upgraded to the RSC Gold subscription, did you realize this means that you now have access to all of the RSC journal, database and magazine content? This means you now have access to Analyst and Analytical Methods! Take a look below at some of the highly cited content we have published recently. These papers will be free to access and read until October 22nd, so do take a look.We hope that you will consider submitting your next paper to Analyst or Analytical Methods.

New RSC Gold subscribers now have access to Analyst

New directions in screen printed electroanalytical sensors: an overview of recent developments
Jonathan P. Metters, Rashid O. Kadara and Craig E. Banks
Analyst, 2011, 136, 1067-1076
DOI: 10.1039/C0AN00894J

Gold nanoparticle probes for the detection of mercury, lead and copper ions
Yang-Wei Lin, Chih-Ching Huang and Huan-Tsung Chang
Analyst, 2011, 136, 863-871
DOI: 10.1039/C0AN00652A

Stable fluorescent gold nanoparticles for detection of Cu²⁺ with good sensitivity and selectivity
Yongming Guo, Zhuo Wang, Huawu Shao and Xingyu Jiang
Analyst, 2012, 137, 301-304
DOI: 10.1039/C1AN15877E

Electrocatalytic oxidation and determination of epinephrine in the presence of uric acid and folic acid at multiwalled carbon nanotubes/molybdenum(VI) complex modified carbon paste electrode
Hadi Beitollahi and Iran Sheikhshoaie
Anal. Methods, 2011, 3, 1810-1814
DOI: 10.1039/C1AY05211J

RSC Gold also gives you access to Analytical Methods

Tetracyanoquinodimethane nanoparticles as an effective sensing platform for fluorescent nucleic acid detection
Hailong Li, Lei Wang, Junfeng Zhai, Yonglan Luo, Yingwei Zhang, Jingqi Tian and Xuping Sun
Anal. Methods, 2011, 3, 1051-1055
DOI: 10.1039/C0AY00746C

Target and non-target screening strategies for organic contaminants, residues and illicit substances in food, environmental and human biological samples by UHPLC-QTOF-MS
Ramon Díaz, María Ibáñez, Juan V. Sancho and Félix Hernández
Anal. Methods, 2012, 4, 196-209
DOI: 10.1039/C1AY05385J

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Analyst Blog

Archive for 2012

Point of Care Diagnostics Workshop – 4 Dec 2012, London UK

Mastering Big Ideas for Small Devices

HOT articles in Analyst this September

Top ten most accessed articles in August

HOT articles in Issue 21 of Analyst

Biological fate of nanoparticles in the body

Seeing cells under stress

Analyst Issue 21 now online!

HOT Article: The future of clinical imaging, Electrical Impedance Tomography

New RSC Gold subscribers have access to Analyst & Analytical Methods

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