Scanning XEOL provides new capabilities for chemical analysis in tissue
The benefits of non-invasive biomedical imaging techniques in studying disease are obvious but developing sensors which can measure chemical concentrations around and on implants is challenging. This is because optical imaging through tissue results in light scattering and in turn, images with poor resolution. Jeffrey Anker and colleagues use a narrow scanning X-ray beam to excite luminescence from X-ray scintillators in this hybrid technique for high-resolution imaging of local optial absorption through tissue. The scintillators serve as light sources with spectra and intensity that depend on local absorption.
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Optical imaging in tissue with X-ray excited luminescent sensors
Hongyu Chen, David E. Longfield, Venkata S. Varahagiri, KhanhVan T. Nguyen, Amanda L. Patrick, Haijun Qian, Donald G. VanDerveer and Jeffrey N. Anker
Analyst
DOI: 10.1039/C0AN00931H
This paper will be included in a themed issue on Emerging Investigators, Guest Edited by Perdita Barran and Christy Haynes, to be published later this year.
