The results preliminarily revealed that modifications of metabolism and associated pathways accounted for metabolic perturbation of the rats that was induced by indomethacin.
Read this HOT paper which combines the use of high-throughput mass spectrometry based metabolomics and ingenuity pathway analysis, a powerful chemomatric approach, to address drug side-effects. By using differentiated global metabolic profiling of urine to phenotype the side effects of indomethacin on specific tissue systems it will elucidate the harmful effects of indomethacin in the kidney and liver, a key obstacle to widening the clinical use of the drug.
The paper will be free to access to until 24th May.
Metabolomic analysis characterizes tissue specific indomethacin-induced metabolic perturbations of rats
Haitao Lv, Lian Liu, Gustavo Palacios and Xi Chen
Analyst, 2011, Advance Article
DOI: 10.1039/C1AN15126F
