Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Total synthesis based on the originally claimed structure of mucosin
Harrison C. Gallantree-Smith, Simen G. Antonsen, Carl H. Görbitz, Trond V. Hansen, Jens M. J. Nolsøe and Yngve H. Stenstrøm
DOI: 10.1039/C6OB01511E, Communication

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Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection
Satish Chandra Philkhana, Suneet Mehrotra, Thomas F. Murray and D. Srinivasa Reddy
DOI: 10.1039/C6OB01372D, Paper

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Microwave assisted synthesis of phenanthridinones and dihydrophenanthridines by vasicine/KOtBu promoted intramolecular C–H arylation
Sushila Sharma, Manoranjan Kumar, Shruti Sharma, Onkar S. Nayal, Neeraj Kumar, Bikram Singh and Upendra Sharma
DOI: 10.1039/C6OB01362G, Paper

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Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid
Hai Yu, Jie Zeng, Yanhong Li, Vireak Thon, Baojun Shi and Xi Chen
DOI: 10.1039/C6OB01706A, Paper

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Chemoselective photooxygenations of furans bearing unprotected amines: their use in alkaloid synthesis
T. Montagnon, D. Kalaitzakis, M. Sofiadis and G. Vassilikogiannakis
DOI: 10.1039/C6OB01689H, Perspective

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A protecting group-free synthesis of (−)-hortonones A–C from the Inhoffen–Lythgoe diol
Hovsep Stambulyan and Thomas G. Minehan
DOI: 10.1039/C6OB01738J, Paper

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Total synthesis of cananginone C and structural revision of debilisone A
Tapan Kumar Kuilya and Rajib Kumar Goswami
DOI: 10.1039/C6OB01671E, Paper

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Total synthesis of mangiferin, homomangiferin, and neomangiferin
Xiong Wei, Danlin Liang, Qing Wang, Xiangbao Meng and Zhongjun Li
DOI: 10.1039/C6OB01622G, Paper

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Substitution dependent stereoselective construction of bicyclic lactones and its application to the total synthesis of pyranopyran, tetraketide and polyrhacitide A
B. V. Subba Reddy, Dhanraj O. Biradar, Y. Vikram Reddy, J. S. Yadav, Kiran Kumar Singarapu and B. Sridhar
DOI: 10.1039/C6OB01686C, Paper

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4,4′-Bismoschamine: biomimetic synthesis and evidence to support structural equivalency to montamine
Kaitlin G. Henry, Lachlan M. Blair, Jonathan Sperry and Elizabeth A. Colby Davie
DOI: 10.1039/C6OB01685E, Paper

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Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors
Ji-tian Liu, Truman J. Do, Christopher J. Simmons, John C. Lynch, Wen Gu, Zhi-Xiong Ma, Wei Xu and Weiping Tang
DOI: 10.1039/C6OB01657J, Communication

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Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin E
Matthew G. Lloyd, Richard J. K. Taylor and William P. Unsworth
DOI: 10.1039/C6OB01527A, Paper

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De novo protecting-group-free total synthesis of (+)-muricadienin, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one
Rupesh A. Kunkalkar, Debasish Laha and Rodney A. Fernandes
DOI: 10.1039/C6OB01721E, Paper

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An expeditious synthesis of the ascomycete metabolite rigidiusculamide B
Anja Wunder and Rainer Schobert
DOI: 10.1039/C6OB01836J, Paper

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Total synthesis of haliclamide
Suraksha Gahalawat and Satyendra Kumar Pandey
DOI: 10.1039/C6OB01775D, Paper

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Preparation of oxocene terpenes. The first enantiospecific synthesis of cytotoxic arenaran A
Alejandro Torres, Pilar Gutierrez, Ramón Alvarez-Manzaneda, Rachid Chahboun and Enrique Alvarez-Manzaneda
DOI: 10.1039/C6OB01640E, Paper

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Synthesis of crinane utilizing an allylic sulfoxide for the construction of a hydroindole ring via vinylogous C–N bond formation
Sadagopan Raghavan and Anil Ravi
DOI: 10.1039/C6OB01966H, Paper

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Total synthesis of wewakazole B
Bohua Long, Jingzhao Zhang, Xudong Tang and Zhengzhi Wu
DOI: 10.1039/C6OB01783E, Communication

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Total synthesis of (±)-ganocins B and C
Yao Liu, Chu-Jun Zhou, Qingjiang Li and Honggen Wang
DOI: 10.1039/C6OB02049F, Communication

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Stereoselective synthesis of (−)-desethyleburnamonine, (−)-vindeburnol and (−)-3-epitacamonine: observation of a substrate dependent diastereoselectivity reversal of an aldol reaction
Pravat Mondal and Narshinha P. Argade
DOI: 10.1039/C6OB01438K, Paper

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Stereoselective construction of 2-vinyl 3-hydroxybenzopyran rings: total syntheses of teadenols A and B
Ryunosuke Yoshida, Hitoshi Ouchi, Atsushi Yoshida, Tomohiro Asakawa, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima and Toshiyuki Kan
DOI: 10.1039/C6OB02004F, Communication

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Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus
Chenxi Zhang, Chengcheng Wang, Zihao Wang, Genzoh Tanabe, Osamu Muraoka, Aijun Lin, Jinyi Xu, Xiaoming Wu, Liang Wu and Weijia Xie
DOI: 10.1039/C6OB02207C, Paper

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SCascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition
Rachel C. Furnival, Rungroj Saruengkhanphasit, Heather E. Holberry, Jonathan R. Shewring, Hélène D. S. Guerrand, Harry Adams and Iain Coldham
DOI: 10.1039/C6OB01871H, Paper

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Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmission
Lindon W. K. Moodie, Monika C. Žužek, Robert Frangež, Jeanette H. Andersen, Espen Hansen, Elisabeth K. Olsen, Marija Cergolj, Kristina Sepčić, Kine Ø. Hansen and Johan Svenson
DOI: 10.1039/C6OB02120D, Paper

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Macrolactam analogues of macrolide natural products
Helmut M. Hügel, Andrew T. Smith and Mark A. Rizzacasa
DOI: 10.1039/C6OB02149B, Review Article

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Enantioselective total synthesis and structural assignment of callyspongiolide
Arun K. Ghosh, Luke A. Kassekert and Joseph D. Bungard
DOI: 10.1039/C6OB02051H, Paper

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Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation
Takayuki Ohyoshi, Yuki Tamura, Ichiro Hayakawa, Go Hirai, Yamato Miyazawa, Shota Funakubo, Mikiko Sodeoka and Hideo Kigoshi
DOI: 10.1039/C6OB02268E, Paper

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Katherine S. Ryan – winner of the 2017 Natural Product Reports Emerging Investigator Lectureship

Congratulations to Katherine S. Ryan on winning the 2017 Natural Product Reports Emerging Investigator Lectureship.

Katherine is an Assistant Professor in the Department of Chemistry at the University of British Columbia where her research group investigates the biosynthetic pathways to microbial natural product molecules.

The Natural Product Reports Emerging Investigator Lectureship is an annual event which is held at an international meeting, the recipient being a researcher who has made a significant contribution to any natural products-related research in their early independent career.

Katherine was selected to receive the lectureship for her significant contributions to understanding the unusual biosynthetic chemistry of antibiotics such as indolmycin and for using modern synthetic biology techniques to rationally generate new bisindole chemistry.

Find out more about Katherine and her research on Katherine’s webpage.

Katherine will be holding her Lectureship at a yet to be determined conference in 2017.

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Asymmetric synthesis and absolute stereochemistry of a labdane-type diterpenoid isolated from the rhizomes of Isodan yuennanensis
Heping Deng, Wei Cao, Zhijiang Zhang and Bo Liu
DOI: 10.1039/C6OB00750C, Paper


Biosynthesis of isoxazolin-5-one and 3-nitropropanoic acid containing glucosides in juvenile Chrysomelina
Tobias Becker, Kerstin Ploss and Wilhelm Boland
DOI: 10.1039/C6OB00899B, Paper


Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152
John D. Sidda, Vincent Poon, Lijiang Song, Weishan Wang, Keqian Yang and Christophe Corre
DOI: 10.1039/C6OB00840B, Communication


Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity
Gaopeng Song, Sumei Li, Zhiwei Lei, Yibin Li, Junhua Li, Yixian Liao and Zi-Ning Cui
DOI: 10.1039/C6OB00862C, Paper


Asymmetric synthesis of (+)-17-epi-methoxy-kauran-3-one through tandem oxidative polycyclization-pinacol process
Gaëtan Maertens, Samuel Desjardins and Sylvain Canesi
DOI: 10.1039/C6OB01142J, Paper


Enantioselective synthesis of (+)-brevipolide H
Ching-Nung Chen and Duen-Ren Hou
DOI: 10.1039/C6OB01071G, Paper


Synthetic studies of callyspongiolide: synthesis of the macrolactone core of the molecule
Sudhakar Athe, Ashish Sharma, Kanakaraju Marumudi and Subhash Ghosh
DOI: 10.1039/C6OB01007E, Paper


Synthesis of L-indospicine, [5,5,6-2H3]-L-indospicine and L-norindospicine
Cheng-Shan Lang, Siew-Hoon Wong, Sharon Chow, Victoria L. Challinor, Ken W. L. Yong, Mary T. Fletcher, Dionne M. Arthur, Jack C. Ng and James J. De Voss
DOI: 10.1039/C6OB01187J, Paper


Synthesis of 2,6-trans– and 3,3,6-trisubstituted tetrahydropyran-4-ones from Maitland–Japp derived 2H-dihydropyran-4-ones: a total synthesis of diospongin B
Paul A. Clarke, Nadiah Mad Nasir, Philip B. Sellars, Alejandra M. Peter, Connor A. Lawson and James L. Burroughs
DOI: 10.1039/C6OB01182A, Paper


Catalytic asymmetric reactions and synthesis of quinones
Basavaprabhu Hosamani, Matheus F. Ribeiro, Eufrânio N. da Silva Júnior and Irishi N. N. Namboothiri
DOI: 10.1039/C6OB01119E, Review Article


Platinum-catalyzed cycloisomerizations of a common enyne: a divergent entry to cyclopropane sesquiterpenoids. Formal synthesis of sarcandralactone A
Vera P. Demertzidou and Alexandros L. Zografos
DOI: 10.1039/C6OB011226D, Communication


Synthesis of the 2-formylpyrrole spiroketal pollenopyrroside A and structural elucidation of xylapyrroside A, shensongine A and capparisine BA
James M. Wood, Daniel P. Furkert and Margaret A. Brimble
DOI: 10.1039/C6OB01361A, Paper


Biosynthesis-driven structure–activity relationship study of premonensin-derivatives A
A. Ismail-Ali, E. K. Fansa, N. Pryk, S. Yahiaoui, S. Kushnir, M. Pflieger, A. Wittinghofer and F. Schulz
DOI: 10.1039/C6OB01201A, Paper


Horner–Wadsworth–Emmons approach to piperlongumine analogues with potent anti-cancer activity
Li-Chen Han, Paul A. Stanley, Paul J. Wood, Pallavi Sharma, Anchala I. Kuruppu, Tracey D. Bradshaw and John E. Moses
DOI: 10.1039/C6OB01160H, Paper


We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?

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Directing Biosynthesis V

Oral abstract deadline 9 October 2016: submit abstracts online here.

Don’t miss out. Submit an oral abstract for this international natural products and chemical biology conference at the University of Warwick. Keynote speakers include Wilfred van der Donk, Janet Smith, John Verderas, Joern Piel and many more. Topics include…

  • Biosynthesis of cell walls – targets for antimicrobials
  • Pathway engineering
  • Enzymology and structural biology
  • Natural products discovery – a response to AMR
  • Chemical ecology

Posters and exhibitors also welcome. Contact events@rsc.org for more information.

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What are your colleagues reading in Natural Product Reports?

The articles below are some of the most read Natural Product Reports articles in April, May and June 2016.


Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C5NP00156K, Review Article

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid
DOI: 10.1039/C3NP20106F, Review Article

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C3NP70117D, Review Article

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C4NP00144C, Review Article

Recent advances in engineering nonribosomal peptide assembly lines
M. Winn, J. K. Fyans, Y. Zhuo and J. Micklefield
DOI: 10.1039/C5NP00099H, Review Article
From themed collection Biosynthetic Assembly Lines

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products
Daniel P. Demarque, Antonio E. M. Crotti, Ricardo Vessecchi, João L. C. Lopes and Norberto P. Lopes
DOI: 10.1039/C5NP00073D, Review Article

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products
Michail Tsakos, Eva S. Schaffert, Lise L. Clement, Nikolaj L. Villadsen and Thomas B. Poulsen
DOI: 10.1039/C4NP00106K, Review Article

Synthetic approaches towards alkaloids bearing α-tertiary amines
Anastasia Hager, Nina Vrielink, Dominik Hager, Julien Lefranc and Dirk Trauner
DOI: 10.1039/C5NP00096C, Review Article

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl and Martin Kaltenpoth
DOI: 10.1039/C5NP00010F, Review Article
From themed collection Chemical Ecology


Have you read our most recent themed issues yet:


Keep up-to-date with the latest issues of Natural Product Reports by joining our e-alerts.

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RSC Organic Division Poster Symposium 2016

Headline sponsored by F. Hoffmann-La Roche, Ltd.

This poster symposium for final year organic chemistry PhD students will take place at The Royal Society of Chemistry at Burlington House, in London, Monday 5 December 2016.

Abstract submission is now open!

The closing date for abstract submissions is Monday 3 October 2016. Get more information or submit an abstract now.

This symposium offers final year PhD students a chance to showcase their research to their peers, leading academics and industrial chemists. It is open to all branches of organic chemistry – in its broadest interpretation – and has a tradition of being the most competitive and highly-regarded organic chemistry symposium for PhD students in the UK and Ireland.

There will be a first prize of £500, two runner-up prizes, and a ‘selected by Industry’ prize. Industrial delegates will select this winner based on the potential for application in an industrial context.

We would like to thank F. Hoffmann-La Roche, Ltd. and our industry sponsors for their generous support of this event.

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Nominations open for 2017 Natural Product Reports Emerging Investigator Lectureship

Nominations are now open for the 2017 Natural Product Reports Emerging Investigator Lectureship.

Nominate by 1 September 2016

The Lectureship recognises a researcher who has made a significant contribution to a natural products-related area of the chemical sciences in their early independent career. Nominations can be made by anyone, so why not nominate a colleague, collaborator, or someone whose work you admire today?

Who can be nominated?
To be eligible for the Natural Product Reports Emerging Investigator Lectureship, any candidate should have completed their PhD on or after 31st December 2007, have started publishing independent papers and have made a significant contribution to natural products-related research.

Lectureship details
The recipient will be invited to present a lecture at a conference during 2017. They will receive £500 towards travel and accommodation costs. They will also be presented with a certificate and be asked to contribute a Natural Product Reports article.

How to nominate
Those wishing to make a nomination should send the following details to the Natural Product Reports Editorial Office by 1 September 2016:

  • The name, affiliation and (if possible) web address of the nominee
  • At least a paragraph outlining the reasons for nomination. This should include brief details of the nominee’s contributions to their field. Additional supporting information, for example their CV, would be helpful but is not mandatory for making a nomination.

Selection procedure
The Natural Product Reports Editorial Board will draw up a short-list of candidates based on the information provided at nomination. The board will then vote to select the recipient at the Autumn Editorial Board meeting, and the winner will be announced in late 2016.

Previous Winners
2013: Rebecca Goss – University of St Andrews, UK
2014: Emily Balskus – Harvard University, USA
2015: Seth Herzon – Yale University, USA
2016: Ryan Shenvi – The Scripps Research Institute, USA

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Ryan Shenvi receives NPR Lectureship at BOS 2016

Prof. Ryan Shenvi winner of the 2016 Natural Product Reports Emerging Investigator Lectureship delivered his lecture “Chemical Synthesis of Secondary Metabolites” at the recent Balticum Organicum Syntheticum held in Riga, Latvia.

As part of the lecture Ryan highlighted research discussed in his recent NPR viewpoint:

Neurite outgrowth enhancement by jiadifenolide: possible targets

Read more about Ryan’s research on the Shenvi lab Homepage

The NPR Lectureship is an annual event which is held at an international meeting, the recipient being a researcher who has made a significant contribution to any natural products-related research in their early independent career.

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‘Microbial protein targets: towards understanding and intervention’ meeting

Hosted by The British Society of Parasitology in collaboration with the Royal Society of Chemistry

Microbial protein targets: towards understanding and intervention

14–16 September 2016, Durham, UK

This symposium will bring together leading expertise in protein structure determination, biochemical characterization and chemical biology to explore the most recent advances in the understanding of protein function and inhibition in microbial pathogens – both bacteria and parasites.

An exciting line-up of speakers will present their recent work in the area. Some of the confirmed speakers are:

  • Chris Abell University of Cambridge, UK
  • Gerald Spaeth Institut Pasteur, Paris, France
  • Ed Tate Imperial College London, UK
  • Maria Marco-Martin GSK Tres Contos, Spain

Take advantage of this opportunity to showcase your work alongside leaders in the field and submit an abstract for an oral or poster presentation today. Through generous sponsorship from the RSC Chemical Biology Interface Division and the BSP there are bursaries available for early career researchers to support their participation at this meeting.

The oral abstract deadline has just been extended until 15 July 2016, and poster abstracts are welcome until 5 August 2016. For more information and to register please visit the conference webpage.

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