Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin
Elizabeth W. Kelley, Skylar G. Norman and Jonathan R. Scheerer
DOI: 10.1039/C7OB02297B

Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA
Karoline Gangestad Primdahl, Jørn Eivind Tungen, Patricia Regina Soares De Souza, Romain Alexandre Colas, Jesmond Dalli, Trond Vidar Hansen and Anders Vik
DOI: 10.1039/C7OB02113E

Total synthesis of (−)-aritasone via the ultra-high pressure hetero-Diels–Alder dimerisation of (−)-pinocarvone
Maliha Uroos, Phillip Pitt, Laurence M. Harwood, William Lewis, Alexander J. Blake and Christopher J. Hayes
DOI: 10.1039/C7OB02204B

Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential
Cheng-Peng Sun, Mahmood Brobbey Oppong, Feng Zhao, Li-Xia Chen and Feng Qiu
DOI: 10.1039/C7OB02205K

Doubling the power of DP4 for computational structure elucidation
K. Ermanis, K. E. B. Parkes, T. Agbackb and J. M. Goodman
DOI: 10.1039/C7OB01379E

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Konrad K. Tiefenbacher selected for the 2018 Natural Product Reports Emerging Investigator Lectureship

The Editorial Board of Natural Product Reports (NPR) is delighted to announce that Professor Konrad K. Tiefenbacher has been chosen to recieve the 2018 Natural Product Reports Emerging Investigator Lectureship for his work on applying supramolecular host structures in terpene chemistry.

About Konrad
Konrad received his chemical basic education at the Technical University of Vienna and the University of Texas in Austin. After finishing his diploma thesis in the lab of Prof. Fröhlich, he pursued his interest in total synthesis of biologically active natural products during a Ph.D. in the lab of Prof. Mulzer at the University of Vienna. He then moved to Prof. Rebek’s lab at The Scripps Research Institute in La Jolla to learn about molecular recognition and self-assembly. In December 2011 he started his independent career as a Juniorprofessor (W1-position) at the Technical University Munich. In June 2016 he was appointed to a dual tenure track assistant professorship at the University of Basel and the ETH Zürich.

You can find out more about Konrad’s research on his webpage.

 

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis
Maria Cecília Zorél Meneghetti, Tarsis Gesteira Ferreira, Alexandre Keiji Tashima, Suely F. Chavante, Edwin Alexander Yates, Jian Liu, Helena Bonciani Nader and Marcelo A. Lima
DOI: 10.1039/C7OB01533J, Paper


A synthetic dodecanolide library for the identification of putative semiochemicals emitted by mantellid frogs
Pardha Saradhi Peram, Miguel Vences and Stefan Schulz
DOI: 10.1039/C7OB00849J, Paper


Forsythenethosides A and B: two new phenylethanoid glycosides with a 15-membered ring from Forsythia suspensa
Si-Yuan Shao, Zi-Ming Feng, Ya-Nan Yang, Jian-Shuang Jiang and Pei-Cheng Zhang
DOI: 10.1039/C7OB01811H, Paper


Total syntheses of gerberinol I and the pterophyllins 2 and 4 using the Casnati–Skattebøl reaction under different conditions
Jorgelina L. Pergomet, Andrea B. J. Bracca and Teodoro S. Kaufman
DOI: 10.1039/C7OB01471F, Paper


Volatiles from the fungal microbiome of the marine sponge Callyspongia cf flammea
Lena Barra, Paul Barac, Gabriele M. König, Max Crüsemann and Jeroen S. Dickschat
DOI: 10.1039/C7OB01837A, Paper


Selective lysine modification of native peptides via aza-Michael addition
Hongli Chen, Rong Huang, Zhihong Li, Wei Zhu, Jiakang Chen, Yuexiong Zhan and Biao Jiang
DOI:10.1039/C7OB01866E, Paper


Synthesis of the fungus metabolite cladosin C
David Linder and Rainer Schobert
DOI:10.1039/C7OB01795B, Paper


18 O2 labeling experiments illuminate the oxidation of ent-kaurene in bacterial gibberellin biosynthesis
Raimund Nagel and Reuben J. Peters
DOI:10.1039/C7OB01819C, Paper


Modular total syntheses of mycolactone A/B and its [2H]-isotopologue
Sarah Saint-Auret, Hajer Abdelkafi, Didier Le Nouen, Laure Guenin-Macé, Caroline Demangel, Philippe Bisseret and Nicolas Blanchard
DOI: 10.1039/C7OB01943B, Communication


A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis
Nina Gerhards and Shu-Ming Li
DOI: 10.1039/C7OB02095C


Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus
Xuan Feng, Nawaf Al Maharik, Axel Bartholomé, Jeffrey E. Janso, Usa Reilly and David O’Hagan
DOI: 10.1039/C7OB02163A


Nazarov reaction: current trends and recent advances in the synthesis of natural compounds and their analogs
Maxim G. Vinogradov, Olga V. Turova and Sergei G. Zlotin
DOI: 10.1039/C7OB01981E

 

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What are you colleagues reading in Natural Product Reports?

The articles below are some of the most read Natural Product Reports articles in April, May and June 2017.

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products
Daniel P. Demarque, Antonio E. M. Crotti, Ricardo Vessecchi, João L. C. Lopes and Norberto P. Lopes
DOI: 10.1039/C5NP00073D

Monomer design strategies to create natural product-based polymer materials
Samantha L. Kristufek, Kevin T. Wacker, Yi-Yun Timothy Tsao, Lu Su and Karen L. Wooley
DOI: 10.1039/C6NP00112B

Marine natural products (2017)
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C6NP00124F

The evolution of genome mining in microbes – a review
Nadine Ziemert, Mohammad Alanjary and Tilmann Weber
DOI: 10.1039/C6NP00025H

Recent advances in engineering nonribosomal peptide assembly lines
M. Winn, J. K. Fyans, Y. Zhuo and J. Micklefield
DOI: 10.1039/C5NP00099H

Chemical proteomics approaches for identifying the cellular targets of natural products
M. H. Wright and S. A. Sieber
DOI: 10.1039/C6NP00001K

Metabolomics in chemical ecology
Constanze Kuhlisch and Georg Pohnert
DOI: 10.1039/C5NP00003C

Phytocannabinoids: a unified critical inventory
Lumír Ondřej Hanuš, Stefan Martin Meyer, Eduardo Muñoz, Orazio Taglialatela-Scafati and Giovanni Appendino
DOI: 10.1039/C6NP00074F

Recent advances in research on lignans and neolignans
Rémy Bertrand Teponno, Souvik Kusari and Michael Spiteller
DOI: 10.1039/C6NP00021E

Marine natural products (2016)
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C5NP00156K

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl and Martin Kaltenpoth
DOI: 10.1039/C5NP00010F

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products
Michail Tsakos, Eva S. Schaffert, Lise L. Clement, Nikolaj L. Villadsen and Thomas B. Poulsen
DOI: 10.1039/C4NP00106K

Synthetic approaches towards alkaloids bearing α-tertiary amines
Anastasia Hager, Nina Vrielink, Dominik Hager, Julien Lefranc and Dirk Trauner
DOI: 10.1039/C5NP00096C

Recent advances in the field of bioactive tetronates
Laura Vieweg, Sebastian Reichau, Rainer Schobert, Peter F. Leadlay and Roderich D. Süssmuth
DOI: 10.1039/C4NP00015C

A tale of four kingdoms – isoxazolin-5-one- and 3-nitropropanoic acid-derived natural products
Tobias Becker, Jacques Pasteels, Christiane Weigel, Hans-Martin Dahse, Kerstin Voigt and Wilhelm Boland
DOI: 10.1039/C6NP00122J

Keep up-to-date with the latest issues of Natural Product Reports with our E-alerts

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions
Peng Fu and John B. MacMillan
DOI: 10.1039/C7OB01178D, Communication


The formation of sesquiterpenoid presilphiperfolane and cameroonane metabolites in the Bcbot4 null mutant of Botrytis cinerea
Gabriel Franco dos Santos, Javier Moraga, Jacqueline A. Takahashi, Muriel Viaud, James R. Hanson, Rosario Hernández Galán and Isidro G. Collado
DOI: 10.1039/C7OB01088E, Paper


Isolation and identification of L/D-lactate-conjugated bufadienolides from toad eggs revealing lactate racemization in amphibians
Shiwen Zhou, Qingfei Zheng, Xiuyong Huang, Yong Wang, Sifan Luo, Renwang Jiang, Lei Wang, Wencai Ye and Haiyan Tian
DOI: 10.1039/C7OB01055A, Paper


Sophopterocarpan A, a novel pterocarpine derivative with a benzotetrahydrofuran-fused bicyclo [3.3.1] nonane from Sophora flavescens
Hui Zhu, Ya-Nan Yang, Kuo Xu, Jing Xie, Zi-Ming Feng, Jian-Shuang Jiang and Pei-Cheng Zhang
DOI: 10.1039/C7OB01261F, Communication


Enzymatic competition and cooperation branch the caerulomycin biosynthetic pathway toward different 2,2′-bipyridine members
Ming Chen, Yipeng Zhang, Yanan Du, Qunfei Zhao, Qinglin Zhang, Jiequn Wu and Wen Liu
DOI: 10.1039/C7OB01284E, Communication


Formal total synthesis of selaginpulvilin D
Bhavani Shankar Chinta and Beeraiah Baire
DOI: 10.1039/C7OB00950J, Paper


Strategy towards the enantioselective synthesis of schiglautone A
Camille Le Chapelain
DOI: 10.1039/C7OB00766C, Paper


Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A
Hugo K. H. Fong, Jean Michel Brunel, Arlette Longeon, Marie-Lise Bourguet-Kondracki, David Barker and Brent R. Copp
DOI: 10.1039/C7OB01122A, Paper


A practical approach to asymmetric synthesis of dolastatin 10
Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si, Zhu Zhou, Xun Sun and Bang-Guo Wei
DOI: 10.1039/C7OB01395G, Paper

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Nominations open for the 2018 NPR Emerging Investigator Lectureship

Nominations are now open for the 2018 Natural Product Reports Emerging Investigator Lectureship.

Nominate by 7 September 2017

This Lectureship recognises a researcher who has made a significant contribution to a natural products-related area of the chemical sciences in their early independent career. Nominations can be made by anyone, so why not nominate a colleague, collaborator, or someone whose work you admire today?

Who can be nominated?
To be eligible for the Natural Product Reports Emerging Investigator Lectureship, any candidate should have completed their PhD on or after 31st December 2008, have started publishing independent papers and have made a significant contribution to natural products-related research.

Lectureship details
The recipient will be invited to present a lecture at a conference during 2018 and will receive £500 towards travel and accommodation costs. They will also be presented with a certificate and be asked to contribute a Natural Product Reports article.

How to nominate
Those wishing to make a nomination should email the following details to the Natural Product Reports Editorial Office by 7 September 2017:

  • The name, affiliation and (if possible) web address of the nominee
  • At least a paragraph outlining the reasons for nomination. This should include brief details of the nominee’s contributions to their field. Additional supporting information, for example their CV, would be helpful but is not mandatory for making a nomination.

Selection procedure
The Natural Product Reports Editorial Board will draw up a short-list of candidates based on the information provided at nomination. The board will then vote to select the recipient at the and the winner will be announced in late 2017.

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Total synthesis of (+)-herboxidiene/GEX 1A
Alejandro Gómez-Palomino, Miquel Pellicena, Katrina Krämer, Pedro Romea, Fèlix Urpí, Gabriel Aullón and José M. Padrón
DOI: 10.1039/C7OB00072C, Paper


First asymmetric total synthesis of aspergillide D
Bighnanshu K. Jena, G. Sudhakar Reddy and Debendra K. Mohapatra
DOI: 10.1039/C6OB02435A, Paper


Torsional steering as friend and foe: development of a synthetic route to the briarane diterpenoid stereotetrad
Nicholas G. Moon and Andrew M. Harned  
DOI: 10.1039/C7OB00124J, Paper


Computational studies on the cyclization of squalene to the steroids and hopenes
B. Andes Hess
DOI: 10.1039/C7OB00222J, Review Article


Isoafricanol synthase from Streptomyces malaysiensis
Patrick Rabe, Markiyan Samborskyy, Peter F. Leadlay and Jeroen S. Dickschat  
DOI: 10.1039/C7OB00234C, Communication


An efficient Ugi-3CR/aza Diels–Alder/Pomeranz–Fritsch protocol towards novel aza-analogues of (±)-nuevamine, (±)-lennoxamine and magallanesine: a diversity oriented synthesis approach
Óscar Vázquez-Vera, Jorge S. Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A. Rentería-Gómez, Shrikant G. Pharande, Carlos J. Cortes-García, Mónica A. Rincón-Guevara, Ilich A. Ibarra, Rocío Gámez-Montaño and Eduardo González-Zamora  
DOI: 10.1039/C6OB02572B, Paper


Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives
Suresh Kumar Mondal, Arabinda Mandal, Susanta Kumar Manna, Sk Asraf Ali, Maidul Hossain, Vangala Venugopal, Avijit Jana and Shubhankar Samanta  
DOI: 110.1039/C7OB00160F, Paper


Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar
Marie Pascaline Rahelivao, Tilo Lübken, Margit Gruner, Olga Kataeva, Rahanira Ralambondrahety, Hanta Andriamanantoanina, Marek P. Checinski, Ingmar Bauer and Hans-Joachim Knölker  
DOI: 10.1039/C7OB00191F, Paper


Total synthesis of phenylpropanoid glycoside osmanthuside-B6 facilitated by double isomerisation of glucose–rhamnose orthoesters
Duc Thinh Khong and Zaher M. A. Judeh  
DOI: 10.1039/C7OB00198C, Paper


Biosynthetic 4,6-dehydratase gene deletion: isolation of a glucosylated jadomycin natural product provides insight into the substrate specificity of glycosyltransferase JadS
S. M. Forget, Jungwook Na, N. E. McCormick and D. L. Jakeman
DOI: 10.1039/C7OB00259A, Communication


Syntheses of C17–C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions
Matthew Ball, Thomas Gregson, Hiroki Omori and Eric J. Thomas  
DOI: 10.1039/C7OB00076F, Paper


Some limitations of an approach to the assembly of bryostatins by ring-closing metathesis
Raphaël Dumeunier, Thomas Gregson, Somhairle MacCormick, Hiroki Omori and Eric J. Thomas  
DOI: 10.1039/C7OB00079K, Paper


Stereochemical investigations of the Tetrahymena cyclase, a model system for euphane/tirucallane biosynthesis
José-Luis Giner and Ju Feng  
DOI: 10.1039/C7OB00296C, Paper


 

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18th International Symposium on the Biology of Actinomycetes (ISBA18)

HeeJu Nah receiving her poster prize certificate

We were pleased to present a prize at the 18th International Symposium on the Biology of Actinomycetes to HeeJu Nah (Department of Biological Engineering, Inha University, Korea) for her poster on:

“Precise Cloning and Heterologous Expression of Natural Product Biosynthetic Gene Cluster Using Streptomyces Artificial Chromosome System.”

The symposium took place in Jeju, Korea on 23 – 27th May 2017.

The International Symposium on the Biology of Actinomycetes is the premier conference in the field, covering all aspects from basic biology through to the applications of the metabolites these fascinating bacteria produce. The conference attracted 582 delegates, with speakers and sponsors from over 30 countries around the world, bringing together both well-established and promising scientists who were keen to discuss Actinobacteria. Actinomycetes are prolific producers of antibiotics and other bioactive natural products, including many compounds used in medicine and agriculture, such as erythromycin, rifampicin, amphotericin, doxorubicin, avermectin and spinosyn.

NPR Board members, Professor Greg Challis, Professor Yeo Joon Yoon and Dr Rebecca Goss were all in attendance at the meeting. Here is what they had to say about the meeting; The 18th meeting in the series featured many exciting talks on the discovery, biosynthesis and bioengineering of actinomycete natural products of direct relevance to readers of NPR. The conference programme included 13 symposia, 3 workshop sessions, 9 plenary lectures and a special lecture by 2015 Nobel Laureate Professor Satoshi Ōmura. Professor Ōmura overviewed the > 400 natural products that his group had isolated, with >20 being of clinical significance. This was particularly impressive, especially when one considers the NMR capability in the early days of his research. This was inspirational to young scientists and students in the field of natural products.

Excitingly, the symposium highlighted the huge acceleration in the field of natural product discovery, enabled by the availability of sequenced actinomycetes genomes, the development of tools for the identification of biosynthetic gene clusters (BGCs) encoded within the genomes, prediction of their products, and the development of technologies enabling access to the products of these previously silent BGCs.

There was a strong strand of fundamental, developmental actinomycetes biology that ran throughout and underpinned the symposium. It is critical to the international community that research into this area remains vibrant and is well supported. Understanding the development and stability of these important antibiotic producers is crucial to optimising and sustaining them for the fermentative production of natural products.

Why not take a look at some related NPR articles here:

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
J. Masschelein, M. Jenner and G. L. Challis
DOI: 10.1039/C7NP00010C

Opportunities for natural products in 21st century antibiotic discovery
Gerard D. Wright
DOI: 10.1039/C7NP00019G

Symbiosis-inspired approaches to antibiotic discovery
Navid Adnani, Scott R. Rajski and Tim S. Bugni
DOI: 10.1039/C7NP00009J

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Katherine S. Ryan receives NPR Lectureship at 9th US-Japan Seminar on Biosynthesis of Natural Products

Professor Katherine S. Ryan winner of the 2017 Natural Product Reports Emerging Investigator Lectureship delivered her lecture on “A PLP-dependent oxidase in the biosynthesis of indolmycin” at the recent 9th US-Japan Seminar on the Biosynthesis of Natural Products at the UCLA Lake Arrowhead Conference Center in California.  

The Natural Product Reports Emerging Investigator Lectureship is an annual event which is held at an international meeting, the recipient being a researcher who has made a significant contribution to any natural products-related research in their early independent career.

Katherine was selected to receive the lectureship for her significant contributions to understanding the unusual biosynthetic chemistry of antibiotics such as indolmycin and for using modern synthetic biology techniques to rationally generate new bisindole chemistry.

Find out more about Katherine and her research on Katherine’s webpage.

Nominations will be open for the 2018 Natural Product Reports Emerging Investigator Lectureship later this year. This will be announced on our blog so check back here regularly.

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Bioinspired total syntheses of terpenoids
Cedric L. Hugelshofer and Thomas Magauer
DOI: 10.1039/C6OB02488B, Perspective

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Total synthesis and confirmation of the revised structures of jiangrines A, C and D
Zhijiang Zhang and Bo Liu
DOI: 10.1039/C6OB02379G, Paper

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Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus
Axel Bartholomé, Jeffrey E. Janso, Usa Reilly and David O’Hagan
DOI: 10.1039/C6OB02291J, Communication

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Enantiospecific total syntheses of meroterpenoids (−)-F1839-I and (−)-corallidictyals B and D
Dattatraya H. Dethe, Balu D. Dherange, Saghir Ali and Mahesh M. Parsutkar
DOI: 10.1039/C6OB02322C, Communication

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Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions
Ichiro Hayakawa, Keita Saito, Sachiko Matsumoto, Shinichi Kobayashi, Ayaka Taniguchi, Kenichi Kobayashi, Yusuke Fujii, Takahiro Kaneko and Hideo Kigoshi
DOI: 10.1039/C6OB02241C, Paper

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The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells
Lilya U. Dzhemileva, Vladimir A. D’yakonov, Aleksey A. Makarov, Evgeny N. Andreev, Milyausha M. Yunusbaeva and Usein M. Dzhemilev  
DOI: 10.1039/C6OB02346K, Paper

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An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (−)-hapalosin
Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou and Bang-Guo Wei  
DOI: 10.1039/C6OB02523D, Paper

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A protecting-group-free synthesis of (+)-nephrosteranic, (+)-protolichesterinic, (+)-nephrosterinic, (+)-phaseolinic, (+)-rocellaric acids and (+)-methylenolactocin
Jothi L. Nallasivam and Rodney A. Fernandes
DOI: 10.1039/C6OB02398C, Paper

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Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis
Tomoshige Hiratsuka, Hideaki Suzuki, Atsushi Minami and Hideaki Oikawa
DOI: 10.1039/C6OB02675C, Communication

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A novel withanolide with an unprecedented carbon skeleton from Physalis angulata
Cheng-Peng Sun, Andrei G. Kutateladze, Feng Zhao, Li-Xia Chen and Feng Qiu  
DOI: 10.1039/C6OB02656G, Communication

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Total synthesis and biological activity of dolastatin 16
Loida O. Casalme, Arisa Yamauchi, Akinori Sato, Julie G. Petitbois, Yasuyuki Nogata, Erina Yoshimura, Tatsufumi Okino, Taiki Umezawa and Fuyuhiko Matsuda  
DOI: 10.1039/C6OB02657E, Paper

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New compounds from a hydrothermal vent crab-associated fungus Aspergillus versicolor XZ-4
Chengqian Pan, Yutong Shi, Xuegang Chen, Chen-Tung Arthur Chen, Xinyi Tao and Bin Wu  
DOI: 10.1039/C6OB02374F, Paper

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Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation
Xing Zhang, Yongmei Xu, Po-Hung Hsieh, Jian Liu, Lei Lin, Eric P. Schmidt and Robert J. Linhardt  
DOI: 10.1039/C6OB02603F, Paper

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Isoafricanol synthase from Streptomyces malaysiensis
Patrick Rabe, Markiyan Samborskyy, Peter F. Leadlay and Jeroen S. Dickschat  
DOI: 10.1039/C7OB00234C, Communication

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An efficient Ugi-3CR/aza Diels–Alder/Pomeranz–Fritsch protocol towards novel aza-analogues of (±)-nuevamine, (±)-lennoxamine and magallanesine: a diversity oriented synthesis approach
Óscar Vázquez-Vera, Jorge S. Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A. Rentería-Gómez, Shrikant G. Pharande, Carlos J. Cortes-García, Mónica A. Rincón-Guevara, Ilich A. Ibarra, Rocío Gámez-Montaño and Eduardo González-Zamora  
DOI: 10.1039/C6OB02572B, Paper

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Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives
Suresh Kumar Mondal, Arabinda Mandal, Susanta Kumar Manna, Sk Asraf Ali, Maidul Hossain, Vangala Venugopal, Avijit Jana and Shubhankar Samanta  
DOI: 10.1039/C7OB00160F, Paper

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