Archive for the ‘News’ Category

Altmetrics now featured on Lab on a Chip

 We are pleased to announce the inclusion of Altmetrics on Lab on a Chip.

With a constantly changing publishing landscape and changes to the way people use scientific literature, altmetrics is a measure that can monitor the level of conversation and interest in a particular piece of research at the article level. Thus altmetrics provides an additional modern metric for our authors to measure the impact of their work, rather than rely solely on citations and impact factor.

To view altmetrics on Lab on a Chip articles, use the Metrics tab as pictured below on the article landing page.

 Altmetrics for LOC 

A press release from Altmetrics is available on our website.

What do you think? We are interested to hear your feedback on this new development and how you are utilising these new types of metrics. Please leave your comments below.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Reprogrammable microfluidic chips

A microfluidic chip with channels that can be programmed then reset and reconfigured has been developed by scientists from France and Japan.

Water is dispensed into chip reservoirs. By selectively switching on electrodes, water is manipulated to carve out the channels

Water is dispensed into chip reservoirs. By selectively switching on electrodes, water is manipulated to carve out the channels

In recent years, scientists from across of the globe have developed a plethora of microfluidic chips to perform a variety of tasks, from PCR to cell sorting. However, a serious drawback of microfluidic technologies is that each application requires a unique arrangement of inlets, outlets and microchannels, so microfluidic chips are usually specific to one particular purpose. This, combined with the time-consuming and costly manufacturing processes required to construct microfluidic devices, makes the idea of a reprogrammable chip very attractive.

Read the full article here at Chemistry World.

Programmable and reconfigurable microfluidic chip
Raphaël Renaudot, et al.
Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50850A, Paper

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Lab on a Chip Co-hosts EU-Korea Microfluidics Workshop

We are very pleased to announce that Lab on a Chip will once again Co-host the third EU-Korea Workshop on microfluidics, focusing on “Emerging Microfluidic Platform Technologies: From Biosciences to Applications”.

Please come along and see us at the meeting, which will be held in Postech International Centre, Pohang, Korea. The workshop takes place on October 3rd to 5th, 2013.

Meet the Editor and International speakers:

Jean-Louis Viovy, Institute Curie, France
Andreas Manz, KIST, Europe
Dongpyo Kim, Pohang, Koreas
Chris Abell, Cambridge, UK
Noo Li Jeon, Seoul, Korea
Sabeth Verpoorte, Groningen, Netherlands
Hywel Morgan, Southampton, UK
Petra Dittrich, ETH Zurich, Switzerland
Sanghyun Lee, FEMTOLAB, Korea
Samuel Sanchez, Max-Planck, Germany
Yoon Kyoung Cho, UNIST, Korea
Francois Leblanc, CEO Fluigent

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free to access HOT articles!

These HOT articles have been recommended by our referees and are free to access for 4 weeks*

Multiplexed single molecule immunoassays
David M. Rissin, Cheuk W. Kan, Linan Song, Andrew J. Rivnak, Matthew W. Fishburn, Qichao Shao, Tomasz Piech, Evan P. Ferrell, Raymond E. Meyer, Todd G. Campbell, David R. Fournier and David C. Duffy  
DOI: 10.1039/C3LC50416F

GA

Rapid fabrication of pressure-driven open-channel microfluidic devices in omniphobic RF paper
Ana C. Glavan, Ramses V. Martinez, E. Jane Maxwell, Anand Bala Subramaniam, Rui M. D. Nunes, Siowling Soh and George M. Whitesides  
DOI: 10.1039/C3LC50371B

GA

A simple three-dimensional-focusing, continuous-flow mixer for the study of fast protein dynamics
Kelly S. Burke, Dzmitry Parul, Michael J. Reddish and R. Brian Dyer
DOI: 10.1039/C3LC50497B

GA

Assessment of pathogenic bacteria using periodic actuation
Sorin David, Cristina Polonschii, Mihaela Gheorghiu, Dumitru Bratu, Alin Dobre and Eugen Gheorghiu  
DOI: 10.1039/C3LC50411E

GA

Microfluidic heart on a chip for higher throughput pharmacological studies
Ashutosh Agarwal, Josue Adrian Goss, Alexander Cho, Megan Laura McCain and Kevin Kit Parker 
DOI: 10.1039/C3LC50350J

GA

Low-cost fabrication of centimetre-scale periodic arrays of single plasmid DNA molecules
Brett Kirkland, Zhibin Wang, Peipei Zhang, Shin-ichiro Takebayashi, Steven Lenhert, David M. Gilbert and Jingjiao Guan   
DOI: 10.1039/C3LC50562F

GA

A novel microfluidic technology for the preparation of gas-in-oil-in-water emulsions
Lu Yang, Kai Wang, Sy Mak, Yankai Li and Guangsheng Luo  
DOI: 10.1039/C3LC50652E

GA

A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction
Sarah L. Perry, Sudipto Guha, Ashtamurthy S. Pawate, Amrit Bhaskarla, Vinayak Agarwal, Satish K. Nair and Paul J. A. Kenis
DOI: 10.1039/C3LC50276G

GA

Steam-on-a-chip for oil recovery: the role of alkaline additives in steam assisted gravity drainage
Thomas W. de Haas, Hossein Fadaei, Uriel Guerrero and David Sinton  
DOI: 10.1039/C3LC50612F

GA

Out of the cleanroom, self-assembled magnetic artificial cilia
Ye Wang, Yang Gao, Hans Wyss, Patrick Anderson and Jaap den Toonder 
DOI: 10.1039/C3LC50458A

GA

Flow switching in microfluidic networks using passive features and frequency tuning
Rachel R. Collino, Neil Reilly-Shapiro, Bryant Foresman, Kerui Xu, Marcel Utz, James P. Landers and Matthew R. Begley  
DOI: 10.1039/C3LC50481F

GA

Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience
Andreas L. Christensen, Christina Lohr, Sune M. Christensen and Dimitrios Stamou  
DOI: 10.1039/C3LC50492A

GA

Pinched-flow hydrodynamic stretching of single-cells
Jaideep S. Dudani, Daniel R. Gossett, Henry T. K. Tse and Dino Di Carlo  
DOI: 10.1039/C3LC50649E

GA

An acoustofluidic micromixer based on oscillating sidewall sharp-edges
Po-Hsun Huang, Yuliang Xie, Daniel Ahmed, Joseph Rufo, Nitesh Nama, Yuchao Chen, Chung Yu Chan and Tony Jun Huang  
DOI: 10.1039/C3LC50568E

GA

Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks
Irep Gözen, Mehrnaz Shaali, Alar Ainla, Bahanur Örtmen, Inga Põldsalu, Kiryl Kustanovich, Gavin D. M. Jeffries, Zoran Konkoli, Paul Dommersnes and Aldo Jesorka  
DOI: 10.1039/C3LC50391G

GA

On-chip microbial culture for the specific detection of very low levels of bacteria
Sihem Bouguelia, Yoann Roupioz, Sami Slimani, Laure Mondani, Maria G. Casabona, Claire Durmort, Thierry Vernet, Roberto Calemczuk and Thierry Livache
DOI: 10.1039/C3LC50473E

GA

Gas/liquid sensing via chemotaxis of Euglena cells confined in an isolated micro-aquarium
Kazunari Ozasa, Jeesoo Lee, Simon Song, Masahiko Hara and Mizuo Maeda
DOI: 10.1039/C3LC50696G

GA

Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array
Isa Navruz, Ahmet F. Coskun, Justin Wong, Saqib Mohammad, Derek Tseng, Richie Nagi, Stephen Phillips and Aydogan Ozcan
DOI: 10.1039/C3LC50589H

GA

Protein–DNA force assay in a microfluidic format
Marcus Otten, Philip Wolf and Hermann E. Gaub  
DOI: 10.1039/C3LC50830G

GA

Ultrasensitive microfluidic solid-phase ELISA using an actuatable microwell-patterned PDMS chip
Tanyu Wang, Mohan Zhang, Dakota D. Dreher and Yong Zeng  
DOI: 10.1039/C3LC50783A

GA

Detection of real-time dynamics of drug–target interactions by ultralong nanowalls
Andreas Menzel, Raphael J. Gübeli, Firat Güder, Wilfried Weber and Margit Zacharias  
DOI: 10.1039/C3LC50694K

GA

Capillarics: pre-programmed, self-powered microfluidic circuits built from capillary elements
Roozbeh Safavieh and David Juncker  
DOI: 10.1039/C3LC50691F

GA

A portable explosive detector based on fluorescence quenching of pyrene deposited on coloured wax-printed μPADs
Regina Verena Taudte, Alison Beavis, Linzi Wilson-Wilde, Claude Roux, Philip Doble and Lucas Blanes  
DOI: 10.1039/C3LC50609F

GA

Electrokinetic tweezing: three-dimensional manipulation of microparticles by real-time imaging and flow control
Zachary Cummins, Roland Probst and Benjamin Shapiro
DOI: 10.1039/C3LC50674F

GA

Albumin testing in urine using a smart-phone
Ahmet F. Coskun, Richie Nagi, Kayvon Sadeghi, Stephen Phillips and Aydogan Ozcan 
DOI: 10.1039/C3LC50785H

GA

*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, simple and more importantly – free – to register!

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube videos

View the new videos on the Lab on a Chip YouTube site using the links below:

 

Aqueous two-phase microdroplets with reversible phase transitions

 

Passive Droplet Sorting using Viscoelastic Flow Focusing 

 

Formation of polymersomes with double bilayers templated by quadruple emulsions

 

A doubly cross-linked nano-adhesive for the reliable sealing of flexible microfluidic devices

 

Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

Flow-switching allows independently programmable, extremely stable, high-throughput diffusion-based gradients

Highly reproducible chronoamperometric analysis in microdroplets

Disaggregation of microparticle clusters by induced magnetic dipole–dipole repulsion near a surface

Exploring a direct injection method for microfluidic generation of polymer microgels

Droplet morphometry and velocimetry (DMV): a video processing software for time-resolved, label-free tracking of droplet parameters

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Circulating cancer cells spiral towards separation

Repeated biopsies of tumours can be a painful and distressing procedure for cancer patients. A new biochip developed by researchers in Singapore can isolate tumour cells from blood samples, and may one day be an alternative to more invasive methods for tracking later stage cancers. 

Operating principle of circulating tumour cell enrichment by a spiral channel with trapezoid cross-section

Operating principle of circulating tumour cell enrichment by a spiral channel with trapezoid cross-section

Deaths from cancer generally occur after the cancer has spread. Cells detach from the primary tumour and travel through the blood, subsequently forming new tumours. Being able to isolate and characterise these circulating tumour cells (CTCs) can provide information about the original tumour. However, CTCs exist in very low numbers in the blood stream and hence require enrichment and separation before analysis. 

Read the full article in Chemistry World 

Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
E W Majid et al, Lab Chip, 2013, Accepted manuscript, Paper
DOI: 10.1039/C3LC50617G

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Marblar Micromixer Challenge!

If you haven’t already heard of Marblar, the crowd-sourcing website that enables many minds to work together to realise the potential of new technologies, then now is the time to find out more, as the Royal Society of Chemistry is sponsoring a Marblar challenge to find  applications for a new microfluidic mixing device developed by Huanming Zia and co-workers based on their 2012 communication in Lab on a Chip!

Converting steady laminar flow to oscillatory flow through a hydroelasticity approach at microscales
H. M. Xia, Z. P. Wang, W. Fan, A. Wijaya, W. Wanga and Z. F. Wanga  
DOI: 10.1039/C1LC20667B

The microfluidic mixer is a non-powered device that can be added in-line to convert laminar flow to oscillatory flow, achieving effective mixing in milliseconds – ordinarily the laminar flow behaviour at these scales means fluid streams only mix very slowly via diffusion, which has been a big limitation for development of microfluidic products.

If you might have an idea or think you could improve on someone else’s, then join in the discussion and maybe even submit an idea or two to win points and marbles!

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Awards for LOC Research Highlights writer Ali Khademhosseini

Congratulations to Ali Khademhosseini, writer of the regular Lab on a Chip Research Highlights articles, who has this year received three prestigious research awards!

In June, he received the 2013 Owens Corning Early Career Award of the American Institute for Chemical Engineers (AIChE) for outstanding contributions in applying micro/nanoscale technologies to engineer functional biomaterials for regenerative medicine. This award recognizes outstanding independent contributions to the scientific, technological, or educational areas of materials science and engineering by a member of the Materials Engineering and Sciences Division of the AIChE under 40. The award will be presented at November’s annual meeting of AIChE in San Francisco.

Professor Khademhosseini was also recently awarded the 2013 IEEE Engineering in Medicine and Biology Society’s Technical Achievement Award. The award is given to recognize outstanding achievement, contribution and/or innovation in a technical area of biomedical engineering. He received the award at the annual EMBS meeting in Japan last week.

In April, we blogged to congratulate Ali on winning the Controlled Release Society Young Investigator award, which will be presented at the end of this month in Hawaii!

View some of Ali’s recent Research Highlights articles here:

Research highlights
Imee G. Arcibal, Donald M. Cropek, Mehmet R. Dokmeci and Ali Khademhosseini 
DOI: 10.1039/C3LC90037A

Research highlights
João Ribas, Mark W. Tibbitt, Mehmet R. Dokmeci and Ali Khademhosseini
DOI: 10.1039/C3LC90032K

Research highlights
Šeila Selimović, Mehmet R. Dokmeci and Ali Khademhosseini
DOI: 10.1039/C3LC90025H

Research highlights
Šeila Selimović, Mark W. Tibbitt, Mehmet R. Dokmeci and Ali Khademhosseini
DOI: 10.1039/C3LC90018E

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chang Lu awarded NIH funding to continue Lab on a Chip work

Congratulations go to Chang Lu at the School of Biomedical Engineering and Sciences at Virginia Tech has been awarded a new National Institutes of Health project to continue his work with Albert Baldwin at The University of North Carolina on the molecular mechanisms of cancer.

Preliminary work by Chang Lu and co-workers published in Lab on a Chip in 2011 focused on histone modification analysis using a microfluidic platform. Their microfluidics device enables traditional chromatin immunoprecipitation assays (ChIP) using much lower numbers of cells in a much quicker time. All steps are conducted on-chip. The assay is coupled with RT-PCR to give a speedier method for analysis of scarce biological samples.

This new grant from the NIH is to continue this work in designing more advanced, more sensitive on-chip ChIP assays as part of the institutes’ National Cancer Initiative.

Read the first paper in Lab on a Chip today:

Histone modification analysis by chromatin immunoprecipitation from a low number of cells on a microfluidic platform
Tao Geng, Ning Bao,   Michael D. Litt, Trevor G. Glaros, Liwu Lid and Chang Lu  
DOI: 10.1039/C1LC20253G

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Video abstracts: Nanofluidic technology

The first ever Video Abstract for an RSC Publishing article is now available to view on the Publishing Platform!

The article chosen to demonstrate the video abstract capability now on the Publishing Platform is a Lab on a Chip Critical Review “Nanofluidic technology for biomolecule applications: a critical review” published in 2010 by Maria Napoli, Jan Eijkel and Sumita Pennathur from University of California Santa Barbara.

The comprehensive review covers the basics of nanofluidics principles and phenomena and its application to studying biomolecules. To find out the critical points covered and work out whether this article would be relevant for you to read in full, all you need to do now is Watch The Video!

Nanofluidic technology for biomolecule applications: a critical review
M. Napoli,   J. C. T. Eijkel and   S. Pennathur
DOI: 10.1039/B917759K  

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)