New Lab on a Chip Associate Editor: Petra S. Dittrich

At Lab on a Chip we are very pleased to announce our newest Associate Editor – Petra Dittrich!

Petra is Associate Professor for Bioanalytics at the Department of Biosystems Science and Engineering. Her research in the field of lab-on-chip-technologies focuses on the miniaturization of high-sensitivity devices for chemical and biological analyses, and microfluidic-aided organization of materials.

Petra’s research group develop miniaturized devices (lab-on-chip technology or microfluidics) for applications in the life sciences. Their interdisciplinary approach combines chemical, physical, biological and engineering aspects of microfluidics-based technology. You can find out more about her research on her homepage: http://www.dittrich.ethz.ch/

Petra is now handling papers so submit your paper to her today!

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Symposium Latsis EPFL 2016: Multicellular organisms in microfluidic systems

The Symposium Latsis EPFL 2016 “Multicellular organisms in microfluidic systems” was held from 14 November 2016 to 16 November 2016 at the EPFL campus in Lausanne (Switzerland). The event was co-organised by Prof. Johan Auwerx and Lab on a Chip Advisory Board member Prof. Martin Gijs.

PhD student Li Dong was presented the Poster Award

Studies of living organisms like nematodes and invertebrate embryos in controlled spatio-temporal chemical environments on microfluidic chips are gaining momentum, as these animals offer genetic amenability, low-cost, and culture conditions that are compatible with large-scale screens, while not raising ethical issues. The Latsis Symposium wanted to bridge the gap between microfluidic systems and biological model organism research, by providing an interdisciplinary forum on the technology and applications of microfluidic systems for studies of multicellular organisms in medicine and biology.

Topics covered in each of the sessions were:

  • Phenotyping
  • Imaging Techniques
  • High-throughput techniques
  • Neurobiology
  • Physiology and Development Studies


Among the speakers presenting at the symposium was Prof. Hang Lu (School of Chemical & Biomolecular Engineering, Georgia, USA), Lab on a Chip Advisory Board member, who spoke on “Deep Phenotyping Enabled by Microfluidics and High-Throughput Quantitative Microscopy”.

Li Dong's winning poster on "On-chip biocommunication through exchange of compounds secreted by male C. elegans nematodes"

A distinction for the best contributed poster of the Symposium was given to Ph.D. student Li Dong of the Laboratory of Microsystems of EPFL. He received an electronic subscription to the RSC journals Lab on a Chip and Integrative Biology.

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Lab on a Chip will not be accepting new Technical Innovations from 1st December 2016

We would like to inform our authors and readers that as a result of the recent change in the journal scope, the Editorial Board has decided that the journal will not accept Technical Innovations for submission from the 1st December 2016 onwards. All Technical Innovations currently under review for the journal will not be affected.

Technical Innovations currently published in the journal cover new and innovative technologies of immediate value to the Lab-on-a-Chip, micro/nanofluidics or miniaturisation communities or offer novel technical insights to new and/or existing problems.

The revised scope highlights that the journal aims to publish work at the interface between physical technological advancements and high impact applications that are of direct interest to a broad audience. The most important criterion used to assess manuscripts that are submitted to Lab on a Chip is novelty. Papers should demonstrate novelty in both: (i) the device physics, engineering, and materials; and (ii) applications in biology, chemistry, medicine. Submissions that describe novelty in both device and application are most likely to be published.

Outstanding articles featuring novelty in either the device or the application may also be published and therefore articles with outstanding innovation in the device technology may still be submitted to the journal, either as Full Papers or Communications.

For presubmission enquries, please contact the Editorial Office.

Submit your latest research here.

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Major society chemistry publishers jointly commit to integration with ORCID

ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship and innovation activities, ensuring authors gain full credit for their work.

Today, we signed their open letter, along with ACS Publications, committing to unambiguous identification of all authors that publish in our journals.

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The Royal Society of Chemistry and the Publications Division of the American Chemical Society (ACS) today each became signatories to the ORCID Open Letter, reasserting the commitment of both organizations to enhancing the scholarly publishing experience for researchers worldwide who are involved in chemistry and allied fields.

The commitment by these two global chemistry publishers to undertake new workflow integration with technology infrastructure provided by ORCID, a not-for-profit organization that provides unique identifiers for researchers and scholars, will enable both societies to provide unambiguous designation of author names within chemistry and across the broader sciences. This partnership with ORCID will resolve ambiguity in researcher identification caused by name changes, cultural differences in name presentation, and the inconsistent use of name abbreviations that is too often a source of confusion for those who must rely on the published scientific record.

By becoming signatories to the ORCID Open Letter, these two major chemical societies are voicing their intent to collect ORCID iDs for all submitting authors through use of the ORCID API, and to display such identifiers in the articles published in their respective society journals. The integration of such activities within the publishers’ workflows means authors will benefit from automated linkages between their ORCID record and unique identifiers embedded within their published research articles, ensuring their contributions are appropriately recognized and credited.

During the publishing process, ACS and the Royal Society of Chemistry will automatically deposit publications to Crossref, which in turn will coordinate with ORCID to link and update the publishing activity populated to authors’ respective ORCID profiles, thus attributing each published work to the correct researcher. Existing holders of an ORCID iD will encounter a one-time prompt to grant permission for the linkage. If authors do not have an ORCID iD, they can easily enroll without navigating away from the publishers’ manuscript submission site. If users wish to revoke integrated ORCID profile access at any time, they can elect to do so through their ACS, Royal Society of Chemistry or ORCID accounts.

Both ACS Publications and the Royal Society of Chemistry understand the importance of attributing accurately the scholarly contributions of research scientists in the context of their other professional activities. “ACS has supported ORCID since the outset of the initiative,” says Sarah Tegen, Ph.D., Vice President of Global Editorial & Author Services at ACS Publications. “We are pleased now to align with the Royal Society of Chemistry in this endeavor, as both societies underscore our willingness not only to encourage and assist our respective authors in establishing their unique ORCID profiles, but also to help tackle the broader challenge of researcher name disambiguation in the scholarly literature. With the integration of author ORCID iDs in our publishing workflows, we will ensure that researchers receive proper credit for their accomplishments.”

Emma Wilson, Ph.D., Director of Publishing at the Royal Society of Chemistry adds, “We have been a supporter of ORCID since 2013, recognizing the benefits it brings to researchers; ORCID can and will make a huge difference to our authors’ ability to gain full credit for their work. ORCID will also help researchers meet the requirements of their research funders — for example, a number of funders have already announced that all grant applicants must now include a researcher’s ORCID iD. A unified system that integrates and links research-related information with accurate and timely linkage to the publishing output of authors has the potential to simplify and speed up their grant applications — something we know is important to researchers.”

“The ACS and the Royal Society of Chemistry have been long-standing supporters of ORCID,” says Laurel Haak, Ph.D., Executive Director, ORCID. “We are pleased to see ORCID integration into ACS and Royal Society of Chemistry Publications systems. This will be a substantial benefit to researchers in the chemistry community, both in improving search and discovery of research articles, and for attribution and recognition of researchers’ contributions to the discipline.”

About the American Chemical Society and ACS Publications

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With nearly 157,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

ACS Publications, a division of the American Chemical Society, is a nonprofit scholarly publisher of 50 peer-reviewed journals and a range of eBooks at the interface of chemistry and allied sciences, including physics and biology. ACS Publications journals are among the most-cited, most-trusted and most-read within the scientific literature. Respected for their editorial rigor, ACS journals offer high-quality service to authors and readers, including rapid time to publication, a range of channels for researchers to access ACS Publications’ award-winning web and mobile delivery platforms, and a comprehensive program of open access publishing options for authors and their funders. ACS Publications also publishes Chemical & Engineering News — the Society’s newsmagazine covering science and technology, business and industry, government and policy, education and employment aspects of the chemistry field.

About the Royal Society of Chemistry

The Royal Society of Chemistry is the world’s leading chemistry community, advancing excellence in the chemical sciences. With over 50,000 members and a knowledge business that spans the globe, we are the U.K.’s professional body for chemical scientists; a not-for-profit organisation with 175 years of history and an international vision for the future. We promote, support and celebrate chemistry. We work to shape the future of the chemical sciences — for the benefit of science and humanity.

About ORCID

ORCID’s vision is a world where all who participate in research, scholarship and innovation are uniquely identified and connected to their contributions across disciplines, borders and time. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship and innovation activities. It provides open tools that enable transparent and trustworthy connections between researchers, their contributions and affiliations. The organization provides this service to help people find information and to simplify reporting and analysis. ORCID is a not-for-profit organization, sustained by fees from member organizations. Its work is open, transparent and non-proprietary. The organization strives to be a trusted component of research infrastructure with the goal of providing clarity in the breadth of research contributions and the people who make them.

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What can a magnet do?

The magic of magnetism can be shown through a simple classroom demonstration of bringing two magnetic pieces together and then trying to pull them apart. The attraction between the opposite poles of the magnets becomes very apparent as you struggle to tear them apart. This simple concept can be applied to lab-on-a-chip devices to eliminate the need for off-device hardware with power requirements, and therefore, enable the use of lab-on-a-chip technology in low-resource settings.

The majority of existing lab-on-a-chip systems use manual pipettes, syringe pumps, or pressure pump systems to manipulate the fluid flow. The dependence on off-chip hardware, however, makes the integration of these systems into low-cost environments rather challenging. Researchers in both, academia and industry think that this challenge can be addressed by “manually operated self-contained microfluidic devices”, which has gained significant attention over the past couple of years. In line with this objective, magnetically-adhesive based valves have for the first time shown to control fluid flow in a microfluidic device in a recent collaboration work by Sandia National Labs and Qorvo Inc. Here, the “magnetic-adhesive based valve” simply consists of a disk magnet seated on a thin ring of adhesive material.

In this study, a microfluidic device is designed to perform bioassays and contains a port connecting two chambers in different planes. The port is closed by an internal magnet located on a pressure-sensitive adhesive tape, and is opened by the help of an external magnet which displaces the internal magnet (figure 1). When the port is open, the reagents can flow in the microchannels, as shown in figure 2. The adhesive tape prevents any leakage within the microchip, while the magnet serves as an actuatable gate for reagents. The microfluidic device, therefore, allows for storage and on-demand transport of different types of reagents (both liquid, solid, and gas) to perform bioassays.

Magnetic-adhesive based valves are fabricated at the millimeter-scale, however, it is possible to manufacture micron-sized valves depending on the resolution of the laser ablation system used to cut the valve layout. Design considerations and characterization of magnetic-adhesive based valves are further addressed in the paper. Apart from this, the self-contained device is made of low-cost materials (such as PMMA and magnetic alloys), resulting in a fabrication cost as low as 0.2 dollars per chip. As portable and low-cost devices start to draw increasing attention in lab-on-a-chip technology, this work might be an important milestone for next generation micro total analysis systems.

Magnetic valves for lab on a chip sytems

Figure 1. Schematic and photos of magnetic-adhesive based valve working mechanism.

Magnetic valves for lab on a chip devices

Figure 2. Controlled transport and reaction of the stored components in a simple, power- and instrument-free manner in a three chambered microfluidic device.

This is a recently published Hot article and you can download it for free* by clicking the link below:

Magnetic-adhesive based valves for microfluidic devices used in low-resource settings

Jason C. Harper, Jenna M. Andrews, Candice Ben, Andrew C. Hunt, Jaclyn K. Murton, Bryan D. Carson, George D. Bachand, Julie A. Lovchik, William D. Arndt, Melissa R. Finley and Thayne L. Edwards

Lab Chip, 2016, Recent HOT Articles

DOI: 10.1039/C6LC00858E


About the Webwriter

Burcu Gumuscu is a postdoctoral fellow in BIOS Lab on a Chip Group at University of Twente in The Netherlands.

Her research interests include development of microfluidic devices for next generation sequencing, compartmentalized organ-on-chip studies, and desalination of water on the microscale .

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Lab on a Chip International Symposium: Droplet-based Microfluidics

Last week Zhejiang University hosted Lab on a Chip’s International Symposium on droplet-based microfluidics in Hangzhou, China.

This high-quality international symposium was an enormous success, with 200 attendees and 22 speakers from around the world. A range of topics were covered, such as “Droplet microfluidics for single studies” by David Weitz (Harvard University), “All-aqueous droplet microfluidics for bio-encapsulation” by Anderson Ho Cheung Shum, (Hong Kong University), “Collective behavior of crowded drops in microfluidic systems” by Sindy Tang (Stanford University) and “Digital microfluidics for chemistry, biology, and medicine” by Aaron Wheeler (University of Toronto). You can read more of Dr Shum’s and Dr Tang’s recently published work on microfluidics in the Lab on a Chip Emerging Investigators 2016 issue.

Droplet-based microfluidics has emerged as one of the most active research fields in microfluidics. As the world’s leading chemistry community, the Royal Society of Chemistry was pleased to collaborate with Zhejiang University to co-organise this symposium, chaired by Prof Qun Fang (Zhejiang University) and co-chaired by Prof Aaron Wheeler (University of Toronto).

Novel microfluidic droplet manipulation technologies were showcased along with their system applications in chemistry, biology, medicine, making this a thoroughly productive interdisciplinary event.

Winners of the Poster Prizes, with Professor Yanyi Huang (far left), Lab on a Chip Advisory Board member, and Maria Southall (far right), Lab on a Chip Deputy Editor

Speakers who presented at the symposium are listed below and also included three Lab on a Chip Associate Editors and multiple Advisory Board members:

  • Daniel T. Chiu, University of Washington, United States
  • Liangyin Chu, Sichuan University, China
  • Petra Dittrich, ETH Zürich, Switzerland
  • Wenbin Du, Institute of Microbiology, Chinese Academy of Sciences, China
  • Yanyi Huang, Peking University, China
  • Xingyu Jiang, National Center for Nanoscience and Technology of China, China
  • Dong-Pyo Kim, Pohang University of Science and Technology, South Korea
  • Jinming Lin, Tsinghua University, China
  • Baohong Liu, Fudan University, China
  • Bifeng Liu, Huazhong University of Science and Technology, China
  • Jiuan Lv, Fudan University, China
  • Nicole Pamme, University of Hull, United Kingdom
  • Jianhua Qin, Dalian Institute of Chemical Physics, CAS, China
  • Anderson Shum, Hongkong University, China
  • Sindy KY Tang, Stanford University, United States
  • David A. Weitz, Harvard University, United States
  • Aaron Wheeler, University of Toronto, Canada
  • Xinghua Xia, Nanjing University, China
  • Jianhong Xu, Tsinghua University, China
  • Jingjuan Xu, Nanjing University, China
  • Chaoyong Yang, Xiamen University, China
  • Zhiling Zhang, Wuhan University, China
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Microrobot gets to grips with bubbles

Written for Chemistry World by Philippa Matthews

A remotely controlled micro-robot uses air bubbles to grip on to and assemble sub-millimetre sized components.

The microgripper lifts a poly(ethylene glycol) diacrylate hydrogel disc (pink) and stacks it on top of a another hydrogel disc (blue). Source: Royal Society of Chemistry

Gripping and manipulating sub-millimetre objects is a tricky problem in microrobotics. Mechanical grasping is difficult at micro level, and techniques such as micro-machined grippers, although very accurate, need to be tethered to a control system and so are unsuitable for work in confined spaces.

To overcome these problems, Metin Sitti and his team from the Max Planck Institute in Germany have developed an untethered microgripper, which uses surface tension, rather than mechanical means, to grab small parts, such as a hair, a cloth fibre or a piece of muscle tissue. The gripper works in an aqueous environment, can grab both hydrophilic and hydrophobic items and, unlike other systems, does not need to be customised to fit to the item.

Read the full article in Chemistry World.


Programmable assembly of heterogeneous microparts by an untethered mobile capillary microgripper

Joshua Giltinan, Eric Diller and Metin Sitti

Lab Chip, 2016, 16, 4445-4457

DOI: 10.1039/C6LC00981F, Paper

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Chips out of the Lab – Outreach at MicroTAS 2016

Written by Darius Rackus

At the Tuesday lunch break of this year’s conference for Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) in Dublin, you may have thought the conference audience was getting significantly younger, despite being in its 20th year. Pupils from local schools filled lecture halls along with members of the conference delegation. Conference chairs Nicole Pamme and Jens Ducrée invited attendees to join 500 local pupils for a science outreach event sharing the capabilities of microfluidic technologies. Pupils attended a lecture by Professor Sabeth Verpoorte explaining what microfluidics and lab-on-a-chip technologies are and had the chance to participate in a number of hands-on activities. The event served to increase student interest in STEM as well as a way for researchers to share activities they use for science outreach.

Pupils had a chance to use real microfluidic chips taken straight from the lab.

Researchers regularly participate in outreach events to promote an interest in STEM subjects. This is often through universities and community science festivals open to the public. Conferences serve as a great opportunity for international researchers to connect and share their work with other like-minded scientists, but in the past have rarely been opportunities to engage with the general public. For the first time in its history, MicroTAS included public engagement in its 2016 programme.

Pupils from eight local schools participated in a number of hands-on activities highlighting lab-on-a-chip technologies. Such activities ranged from interacting with large-scale versions of chips to trap ping-pong balls (cells); applying fabrication technology like injection molding to produce chocolate treats; to using microfluidic chips that volunteers brought and demonstrated. The outreach event was made possible through financial support from the RSC Outreach Fund, the Institute of Physics (Ireland), and the Analytical Chemistry Trust Fund. Eilish McLoughlin, Director of the Centre for the Advancement of STEM Teaching and Learning (CASTeL) at Dublin City University connected the conference with local schools, and Mark Tarn (Leeds University) coordinated all the conference volunteers. Volunteers represented 20 different universities and companies, highlighting a range of possibilities for careers in STEM.

Pupils file in for the event in Dublin. (Photo credit Tae Jae Lee).

Professor Pamme, who spearheaded the event, wanted to create an opportunity for researchers to share the different types of educational activities they have developed using microfluidics. Publications using microfluidics as a teaching tool do crop up in the literature (for example: Lab on a Chip, 12, 696-701; Lab on a Chip, 15, 947-957), but many microfluidic outreach and teaching activities do not get published. Professor Pamme hoped that there would be cross-pollination of ideas by having volunteers help out with peers at different institutions. A poster exhibit highlighting all the different activities was on display for the duration of the conference and these will be available from the Chemical and Biological Microsystems Society website (the host organization for MicroTAS).

This year’s outreach event may well serve as a template for future MicroTAS conferences as well as for other disciplines including outreach as a part of their international meetings.

Outreach organizers (from left to right) Mark Tarn, Nicole Pamme, and Jens Ducree.

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New YouTube Videos

The importance of travelling wave components in standing surface acoustic wave (SSAW) systems

Multiple actuation microvalves in wax microfluidics

Multiple actuation microvalves in wax microfluidics

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Lab on a Chip awards prestigious prizes at MicroTAS 2016

The µTAS 2016 Conference was held during 9-13th October in Dublin, Ireland. Sam Keltie and Maria Southall, Executive and Deputy Editors of Lab on a Chip, attended this conference and announced the prestigious Lab on a Chip awards which include the Pioneers of Miniaturization Lectureship (in partnership with Corning Inc), the Widmer Young Researcher Poster Prize, the Art in Science competition (in partnership with NIST) and the µTAS video competition (in partnership with Dolomite Microfluidics). The competition was tough but we are pleased to announce this year’s Prize Winners below.


“Pioneers of Miniaturization” Lectureship

Congratulations to all of our Prize Winners: Dr Daniel Irimia (top left), Vaibhav Jain (top right), Enrica Rollo (bottom right) and Adam Churchman (bottom right).

Dr Daniel Irimia (Massachusets General Hospital) was announced as the winner of the 11th “Pioneers of Miniaturization” Lectureship, sponsored by Lab on a Chip and Corning Inc and supported by the Chemical and Biological Microsystems Society (CBMS). The “Pioneers of Miniaturization” Lectureship rewards early to mid-career scientists who have made extraordinary or outstanding contributions to the understanding or development of miniaturised systems. Dr Daniel Irimia received a certificate and a monetary award from Po Ki Yuen (Corning Inc), and delivered a short lecture titled “The amazing neutrophil: unexpected insights from tiny devices” at the conference.

Art in Science Competition

Lab on a Chip and Darwin Reyes from the National Institute of Standards Technology (NIST) presented the Art in Science award to Vaibhav Jain, Purdue University. The award aims to highlight the aesthetic value in scientific illustrations while still conveying scientific merit. You can see his winning photograph “The Rising Sun” along with the runner ups on our Art in Science blog post.

µTAS Video Competition

Lab on a Chip and Dolomite Microfluidics announced Enrica Rollo (EPFL) as the winner of the 2016 µTAS Video Competition supported by the Chemical and Biological Microsystems Society (CBMS). µTAS participants were invited to submit short videos with a scientific or educational focus.The winners baked a micropillar chocolate cake! The full video can be viewed on our YouTube channel along with the runner up video “Keep calm and keep’em separated” by Burcu Gumuscu (University of Twente). Mark Gilligan of Dolomite presented the winner with a voucher for Dolomite equipment.

Widmer Young Researcher Poster Prize

The Widmer Young Researcher Poster Prize was awarded to Adam Churchman, PhD student at Leeds University. His poster highlighted his research on the formation of oil layer inside microbubbles through single step microfluidics.

Also of interest: Browse through our collection of archived µTAS Abstracts online!

Congratulations to all the winners at the conference! We look forward to seeing you at µTAS 2017 in Savannah, Georgia.

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Microfluidics made easy

Written for Chemistry World by Eleanor Hall

Automated design helps researchers find the right chip for the job

Scientists in the US have devised an algorithmic process to speed up the design of microfluidic chips, generating a library containing thousands of different chip designs that researchers can search by functionality.

Microfluidic chips, which are widely used in areas such as disease diagnostics and DNA sequencing, consist of tiny channels etched into a glass or plastic. These microchannels are connected to achieve a specific function, for example mixing fluids. The design process, however, has remained relatively unchanged since their emergence as William Grover from the University of California, who led the new study, explains: ’We design them by hand and we test them – if they work great, but more often than not, they don’t, so then I have to start all over again. That process is so slow and inefficient.’

With a new online database created by Grover and his team, even researchers with no microfluidics experience can find the perfect chip to suit their needs. Grover’s team created a computer program that generates thousands of random microfluidic chip designs and simulates their behaviour. The database collects these simulated designs, and users can query it to find chips suitable for given tasks.

Read the full article in Chemistry World.


Random design of microfluidics

Junchao Wang, Philip Brisk and William H. Grover

Lab Chip, 2016, Advance Article

DOI: 10.1039/C6LC00758A, Paper

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