Dr Bhatia conducts research at the intersection of engineering, medicine, and biology to develop novel platforms for understanding, diagnosing, and treating human disease. Her ‘tiny technologies’ interface living cells with synthetic systems, enabling new applications in tissue regeneration, stem cell differentiation, medical diagnostics and drug delivery. She and her colleagues were the first to demonstrate that microfabrication technologies used in semiconductor manufacturing could be used to organize cells of different types to produce a tissue with emergent properties. Dr. Bhatia’s findings have produced high-throughput-capable human microlivers, which model human drug metabolism, drug-induced liver disease, and interaction with human pathogens. Her group also develops nanoparticles and nanoporous materials that can be designed to assemble and communicate to diagnose and treat a variety of diseases, including cancer.
Dr. Bhatia co-authored the first undergraduate textbook on tissue engineering and has published more than 150 manuscripts, that have been cited over 13,500 times. She and her 150+ trainees have contributed to more than 40 issued or pending patents and launched 9 biotechnology companies with close to 100 products. She is a frequent advisor to governmental organizations and consults widely for academia and industry.
Dr. Bhatia holds a B.S. from Brown University; an M.S. in mechanical engineering from MIT; a Ph.D. in biomedical engineering from MIT; and an M.D. from Harvard Medical School and currently she directs the Laboratory for Multiscale Regenerative Technologies at MIT. She is a Howard Hughes Medical Institute Investigator and the John J. and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT. She is a member of the Institute for Medical Engineering and Science and the Koch Institute for Integrative Cancer Research at MIT, a senior member of the Broad Institute, and a biomedical engineer at Brigham & Women’s Hospital. Dr. Bhatia is an elected Fellow of the Massachusetts Academy of Sciences, Biomedical Engineering Society, American Institute for Medical and Biological Engineering, and the American Society for Clinical Investigation.
We would like to congratulate Dr Bhatia on this achievement!
The microfluidic model is etched into a calcite crystal
Scientists in Canada have developed a new microfluidic model carved from rock, which can replicate the conditions found in underground oil reservoirs in a laboratory with more accuracy than ever before. Using it to study the processes that occur in these reservoirs could lead to greater oil yields.
David Sinton’s group, at the University of Toronto, hope that the model they’ve developed will allow them to properly study the rock structure, and see how it’s affected by oil extraction techniques. The techniques could then be optimised to make them much more efficient.
Have you made a great scientific discovery but are not sure how to convert it into a commercially successful product?
The Dolomite Centre, in collaboration with Lab-on-a-Chip journal and Integrative Biology journal are pleased to announce that the Dolomite and Lab on a Chip Productizing Science® Competition 2015 will open on the 1st of October 2014
We invite registered μTAS participants to submit short videos (see full conditions of entry below) that are either scientifically or educationally focused. Videos may be fun, artistic or just surprising and unusual in order to meet these criteria.
Dolomite Microfuidics, innovators in microfluidic solutions, have generously agreed to support this competition with $2500 worth of Dolomite equipment as the prize.
If you think you have the necessary visual science to take home the prize money, have a read of the entry conditions below!
Deadline 10th October 2014
Video Award Submission Process – Easy 3 Step Process
Step 1.Sign-In to the Electronic Form Using Your Registration Number (submissions can be made between July 25 and October 10, 2014. Form available at www.microTAS2014.org from July 25)
Please have your Abstract/Manuscript Number accessible. If you are unable to locate your Abstract/Manuscript Number, please contact info@microTAS2014.org.
Step 2. Fill in Remaining Information on Electronic Submission Form
Please fill in remaining information on the electronic submission form including title of image and your caption.
Step 3. Upload Your Video
All entries are to be submitted in MP4 or MOV format online via this website. Entries will not be accepted by email, fax, or post. Once your entry has been successfully uploaded and submitted, you will be given an entry number and you will be sent a confirmation email with the information you provided, minus the image. The ability to submit an image will close Friday, 10 October 2014 at 23:59 Honolulu, Hawaii, USA time (HST. GMT minus 10 hours).
Conditions of entry:
1. Only registered participants can take part/submit videos
2. Videos must be either scientific (demonstrating interesting aspects) or educational (enhancing understanding) with respect to micro or nanofluidics
3. Videos can be presented in a fun way
4. Videos can be presented in an artistic way
5. Videos can be presented in a surprising or unusual way
6. Videos can be enhanced by audio, animations or annotations, if necessary
7. Videos should be no longer than 2 minutes in length and file sizes must be compressed as much as possible for submission
8. Videos must be viewable on a PC without bespoke software
9. All submissions are submitted on the basis that they may be used by Lab on a Chip and/or CBMS for promotional purposes in any form
10. Judging by an international panel of judges will take place at μTAS 2014. The judge’s decision will be final and no discussion will be entertained.
11. The prize will be awarded at μTAS 2014 and a written voucher for the equipment will be handed over to the person submitting the winning entry.
Finally, just for a bit of inspiration, here’s a classic Lab on a Chip video from our YouTube Channel…enjoy!
Collaborators across the University of Augsburg, Harvard University, and the University of Glasgow create a fluorescence-activated cell sorter relying on acoustofluidics to guide particles to their final location.
Traditional fluorescence-activated cell and droplet sorting (FACS, FADS) machines are expensive and require considerable time for analysis as well as maintenance (i.e., rinsing and cleaning of tubing to prepare for RNase-free processing). Cheap and disposable microfluidic devices can alleviate the expense and maintenance required, but still lag in particle sorting speed because they depend on fluidic, dielectric, and magnetic actuation to direct particles after fluorescence interrogation.
Lothar Schmid, David Weitz, and Thomas Franke overcame these issues by using traveling surface acoustic waves (SAWs) to drive particles into select channels based on readout of a fluorescent signal. The group oscillated PDMS structures from below by embedded interdigitated transducers to achieve focused acoustic radiation forces which gently moved droplets and cells via acoustic streaming.
The group was able to achieve sorting independent of cell size and compressibility on the order of 3000 particles/second into multiple outlet channels. This fast separation of particles given fluorescence signal readout enables efficient sorting of populations which vary widely in shape and volume. Further, the particles did not have to be first encapsulated into drops. This simplification avoids biohazard aerosol formation, provides higher signal to noise on the fluorescent signal interrogation, and streamlines the separation process. The group demonstrated gentle sorting of melanoma cells in a single fluid based on metabolic activity and membrane integrity. It will be exciting to see how acoustic streaming can further be used to direct particles to aid rare cell separations and cell isolations from complex samples.
You can download the full article for free* until the 24th October 2014:
The transformation of time-varying signals into spatially-varying signals is fundamental for recording temporal information. For trees, growth rings that form throughout their lifetime provide a historical record of their growth conditions. Now, a team led by Sindy Tang at Stanford University, US, have designed a time capsule to record information about the occurrence of chemical events.
The Top 10% represents our highest impact papers, which demonstrate a breakthrough in device technology or methodology, or demonstrate important new results. The papers included are chosen by our Editor from among the Lab on a Chip HOT articles, which score highly in peer review.
We’ve added four new papers to the Top 10%. Download your copies by clicking the links below…