Organic Chemistry Frontiers Blog

Organic Chemistry Frontiers is delighted to share with you the HOT articles from 2015. The papers are recommended by our referees for the high novelty and significance of reported studies.

A selection of articles from the collection is available below. The full collection is free to access until 15^th Feb 2016 from http://rsc.li/ocfhot15

Now is your chance to read some of the high quality articles from Organic Chemistry Frontiers!

Regioselective palladium(II)-catalyzed aerobic oxidative Heck-type C3 alkenylation of sulfocoumarins

Namhoon Kim, Minsik Min and Sungwoo Hong

Org. Chem. Front., 2015,2, 1621-1624
DOI: 10.1039/C5QO00294J

Rhodium catalysed conversion of carbenes into ketenes and ketene imines using PNN pincer complexes

Z. Tang, S. Mandal, N. D. Paul, M. Lutz, P. Li, J. I. van der Vlugt and B. de Bruin   

Org. Chem. Front., 2015,2, 1561-1577
DOI: 10.1039/C5QO00287

Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles

Shuai Wang, Li-Jun Yang, Jun-Liang Zeng, Yan Zheng and Jun-An Ma

Org. Chem. Front., 2015,2, 1468-1474
DOI: 10.1039/C5QO00219B

A thermally stable pH-responsive “supramolecular buckle” based on the encapsulation of 4-(4-aminophenyl)-N-methylpyridinium by cucurbit[8]uril

Tian-You Zhou, Qiao-Yan Qi, Ying Zhang, Xiao-Na Xu and Xin Zhao

Org. Chem. Front., 2015,2, 1030-1034
DOI: 10.1039/C5QO00168D

Intramolecular C–H insertion vs. Friedel–Crafts coupling induced by silyl cation-promoted C–F activation

Oliver Allemann, Kim K. Baldridge and Jay S. Siegel

Org. Chem. Front., 2015,2, 1018-1021
DOI: 10.1039/C5QO00170F

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Organoselenium-catalyzed synthesis of indoles through intramolecular C–H amination
Xuelin Zhang, Ruizhi Guo and Xiaodan Zhao
Org. Chem. Front., 2015,2, 1334-1337
DOI: 10.1039/C5QO00179J, Research Article

Efficient synthesis of P-chiral biaryl phosphonates by stereoselective intramolecular cyclization
Guangqing Xu, Minghong Li, Shouliang Wang and Wenjun Tang
Org. Chem. Front., 2015,2, 1342-1345
DOI: 10.1039/C5QO00142K, Research Article

Palladium-catalyzed methylene C(sp³)–H arylation of the adamantyl scaffold
Ye-Xing Lao, Jia-Qiang Wu, Yunyun Chen, Shang-Shi Zhang, Qingjiang Li and Honggen Wang
Org. Chem. Front., 2015,2, 1374-1378
DOI: 10.1039/C5QO00218D, Research Article

Speciation and kinetic study of iron promoted sugar conversion to 5-hydroxymethylfurfural (HMF) and levulinic acid (LA)
Yuan Jiang, Linan Yang, Christine M. Bohn, Guannan Li, Dong Han, Nathan S. Mosier, Jeffrey T. Miller, Hilkka I. Kenttämaa and Mahdi M. Abu-Omar
Org. Chem. Front., 2015,2, 1388-1396
DOI: 10.1039/C5QO00194C, Research Article

Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123)
En-Jian Han, Yan Sun, Qian Shen, Qing-Yun Chen, Yong Guo and Yan-Gen Huang
Org. Chem. Front., 2015,2, 1379-1387
DOI: 10.1039/C5QO00210A, Research Article

Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles
Shuai Wang, Li-Jun Yang, Jun-Liang Zeng, Yan Zheng and Jun-An Ma
Org. Chem. Front., 2015,2, 1468-1474
DOI: 10.1039/C5QO00219B, Research Article

Stereoselective formation of chiral trans-4-hydroxy-5-substituted 2-pyrrolidinones: syntheses of streptopyrrolidine and 3-epi-epohelmin A
Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei and Guo-Qiang Lin
Org. Chem. Front., 2015,2, 1485-1499
DOI: 10.1039/C5QO00250H, Research Article

Direct borylation of benzyl alcohol and its analogues in the absence of bases
Zhi-Chao Cao, Fei-Xian Luo, Wen-Juan Shi and Zhang-Jie Shi
Org. Chem. Front., 2015,2, 1505-1510
DOI: 10.1039/C5QO00243E, Research Article

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Sulfone promoted Rh(III)-catalyzed C–H activation and base assisted 1,5-H shift strategy for the construction of seven-membered rings
Dianpeng Chen, Gangdong Xing and Hongwei Zhou
Org. Chem. Front., 2015,2, 947-950
DOI: 10.1039/C5QO00089K, Research Article

Palladium-catalyzed direct ortho C–O bond construction of azoxybenzenes with carboxylic acids and alcohols
Duo Zhang, Xiuling Cui, Fangfang Yang, Qianqian Zhang, Yu Zhu and Yangjie Wu
Org. Chem. Front., 2015,2, 951-955
DOI: 10.1039/C5QO00120J, Research Article

Catalytic enantioselective synthesis of quaternary 3,3′-indolyloxindoles by combination of Rh(II) complexes and chiral phosphines
Dian-Feng Chen, Chen-long Zhang, Yue Hu, Zhi-Yong Han and Liu-Zhu Gong
Org. Chem. Front., 2015,2, 956-960
DOI: 10.1039/C5QO00151J, Research Article

Syntheses of sceptrins and nakamuric acid and insights into the biosyntheses of pyrrole–imidazole dimers
Xiaolei Wang, Yang Gao, Zhiqiang Ma, Rodrigo A. Rodriguez, Zhi-Xiang Yu and Chuo Chen
Org. Chem. Front., 2015,2, 978-984
DOI: 10.1039/C5QO00165J, Research Article

A novel dynamic pseudo[1]rotaxane based on a mono-biotin-functionalized pillar[5]arene
Xuan Wu, Mengfei Ni, Wei Xia, Xiao-Yu Hu and Leyong Wang
Org. Chem. Front., 2015, Advance Article
DOI: 10.1039/C5QO00159E, Research Article

Intramolecular C–H insertion vs. Friedel–Crafts coupling induced by silyl cation-promoted C–F activation
Oliver Allemann, Kim K. Baldridge and Jay S. Siegel
Org. Chem. Front., 2015, Advance Article
DOI: 10.1039/C5QO00170F, Research Article

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF₂H
Sheng-Qing Zhu, Xiu-Hua Xu and Feng-Ling Qing
Org. Chem. Front., 2015, Advance Article
DOI: 10.1039/C5QO00186B, Research Article

A thermally stable pH-responsive “supramolecular buckle” based on the encapsulation of 4-(4-aminophenyl)-N-methylpyridinium by cucurbit[8]uril
Tian-You Zhou, Qiao-Yan Qi, Ying Zhang, Xiao-Na Xu and Xin Zhao
Org. Chem. Front., 2015, Advance Article
DOI: 10.1039/C5QO00168D, Research Article

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Sulfur-containing stable five-membered “cycloallene” complexes: 1-thia-2-zircona- and 1-thia-2-titanacyclopenta-3,4-dienes
Noriyuki Suzuki, Takumi Asada, Akiko Kawamura and Yoshiro Masuyama
Org. Chem. Front., 2015,2, 681-687
DOI: 10.1039/C5QO00072F, Research Article

Highly efficient and practical hydrogenation of olefins catalyzed by in situ generated iron complex catalysts
Na Guo, Meng-Yang Hu, Ye Feng and Shou-Fei Zhu
Org. Chem. Front., 2015,2, 692-696
DOI: 10.1039/C5QO00064E, Research Article

A challenging Heck reaction of maleimides
Li Hui Lim and Jianrong (Steve) Zhou
Org. Chem. Front., 2015,2, 775-777
DOI: 10.1039/C5QO00015G, Research Article

Ruthenium-catalyzed alkoxycarbonylation of alkenes using carbon monoxide
Lipeng Wu, Qiang Liu, Ralf Jackstell and Matthias Beller
Org. Chem. Front., 2015,2, 771-774
DOI: 10.1039/C5QO00071H, Research Article

Mechanistic studies on C–C reductive coupling of five-coordinate Rh(III) complexes
Shanshan Chen, Yan Su, Keli Han and Xingwei Li
Org. Chem. Front., 2015,2, 783-791
DOI: 10.1039/C5QO00049A, Research Article

Palladium-catalyzed intramolecular rearrangement of vinylidenecyclopropanes through C–C bond activation
Dong Pan, Gen-Qiang Chen, Xiang-Ying Tang and Min Shi
Org. Chem. Front., 2015,2, 792-796
DOI: 10.1039/C5QO00127G, Research Article

Pd-catalyzed Heck cyclization and in situ hydrocarboxylation or hydromethenylation via a hydrogen borrowing strategy
Xianglei Liu and Zhenhua Gu
Org. Chem. Front., 2015,2, 778-782
DOI: 10.1039/C5QO00091B, Research Article

Formal synthesis of (−)-platensimycin
Zhi-Wei Jiao, Yong-Qiang Tu, Qing Zhang, Wen-Xing Liu, Shao-Hua Wang and Min Wang
Org. Chem. Front., 2015,2, 913-916
DOI: 10.1039/C5QO00109A, Research Article

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Phase-transfer-catalyzed asymmetric desymmetrizations of cyclopentanones
Seiji Shirakawa, Takashi Tokuda, S. B. Jennifer Kan and Keiji Maruoka
Org. Chem. Front., 2015,2, 336-339
DOI: 10.1039/C4QO00339J, Research Article

Cu- or Fe-catalyzed C–H/C–C bond nitrogenation reactions for the direct synthesis of N-containing compounds
Yujie Liang, Yu-Feng Liang and Ning Jiao
Org. Chem. Front., 2015,2, 403-415
DOI: 10.1039/C4QO00350K, Tutorial Account

Meinwald-type rearrangement of monosubstituted epoxides to methyl ketones using an [Al porphyrin]+[Co(CO)4]− catalyst
Jessica R. Lamb, Yukyung Jung and Geoffrey W. Coates
Org. Chem. Front., 2015,2, 346-349
DOI: 10.1039/C4QO00324A, Research Article

Au(I) π-bis(tert-butyldimethylsilyl)acetylene triphenylphosphine complex, an effective pre-catalyst for Au(I)-catalyzed reactions
Dapeng Zhu, Xin Cao and Biao Yu
Org. Chem. Front., 2015,2, 360-365
DOI: 10.1039/C5QO00023H, Research Article

TEMP and copper cocatalyzed oxygenation of ketones with molecular oxygen: chemoselective synthesis of α-ketoesters
Xiaoqiang Huang, Xinwei Li, Miancheng Zou, Jun Pan and Ning Jiao
Org. Chem. Front., 2015,2, 354-359
DOI: 10.1039/C5QO00028A, Research Article

Pd(II)-catalyzed asymmetric addition of arylboronic acids to cyclic N-sulfonyl ketimine esters and a DFT study of its mechanism
Mao Quan, Guoqiang Yang, Fang Xie, Ilya D. Gridnev and Wanbin Zhang
Org. Chem. Front., 2015,2, 398-402
DOI: 10.1039/C4QO00347K, Research Article

Alkyl- and aryl-thioalkylation of olefins with organotrifluoroborates by photoredox catalysis
Yanjie Li, Kazuki Miyazawa, Takashi Koike and Munetaka Akita
Org. Chem. Front., 2015,2, 319-323
DOI: 10.1039/C4QO00352G, Research Article

New building blocks for iminosugars: a concise synthesis of polyhydroxylated N-alkoxypiperidines through an intramolecular azepine ring contraction
Korry L. Barnes, Kelly Chen, Vincent J. Catalano and Christopher S. Jeffrey
Org. Chem. Front., 2015,2, 497-501
DOI: 10.1039/C4QO00330F, Research Article

Regio- and stereoselective synthesis of α-hydroxy-β-azido tetrazoles
Pierre Quinodoz, Cheikh Lo, Mikhail Kletskii, Oleg Burov, Jérôme Marrot and François Couty
Org. Chem. Front., 2015,2, 492-496
DOI: 10.1039/C4QO00345D, Research Article

A one-pot dilithiation–lithium–zinc exchange–Negishi coupling approach to 2,6-di(hetero)aryl substituted dithienothiazines – a novel class of electronically fine-tunable redox systems
Catherine Dostert and Thomas J. J. Müller
Org. Chem. Front., 2015,2, 481-491
DOI: 10.1039/C5QO00046G, Research Article

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Difluoromethyl 2-pyridyl sulfone: a versatile carbonyl gem-difluoroolefination reagent
Bing Gao, Yanchuan Zhao, Jingyu Hu and Jinbo Hu
Org. Chem. Front., 2015,2, 163-168
DOI: 10.1039/C4QO00291A, Tutorial Account

Cationic Pd(II)-catalyzed cyclization of N-tosyl-aniline tethered alkynyl ketones initiated by hydropalladation of alkynes: a facile way to 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives
Kun Shen, Xiuling Han, Guoqin Xia and Xiyan Lu
Org. Chem. Front., 2015,2, 145-149
DOI: 10.1039/C4QO00286E, Research Article

Simple, versatile, and chemoselective reduction of secondary amides and lactams to amines with the Tf₂O–NaBH₄ or Cp₂ZrHCl–NaBH₄ system
Pei-Qiang Huang and Hui Geng
Org. Chem. Front., 2015,2, 150-158
DOI: 10.1039/C4QO00317A, Research Article

Gold(I)-catalyzed asymmetric [3 + 2]-cycloadditions of γ-1-ethoxyethoxy-propiolates and aldehydes
Feng Liu, Yidong Wang, Weiming Ye and Junliang Zhang
Org. Chem. Front., 2015,2, 221-225
DOI: 10.1039/C4QO00261J, Research Article

Indolizine synthesis via Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with nucleophiles
Ren-Rong Liu, Zheng-Yi Cai, Chuan-Jun Lu, Shi-Chun Ye, Bin Xiang, Jianrong Gao and Yi-Xia Jia
Org. Chem. Front., 2015,2, 226-230
DOI: 10.1039/C4QO00336E, Research Article

Selective syntheses of leuconolam, leuconoxine, and mersicarpine alkaloids from a common intermediate through regiocontrolled cyclizations by Staudinger reactions
Zining Li, Qian Geng, Zhe Lv, Beau P. Pritchett, Katsuaki Baba, Yoshitaka Numajiri, Brian M. Stoltz and Guangxin Liang
Org. Chem. Front., 2015,2, 236-240
DOI: 10.1039/C4QO00312H, Research Article

N-heterocyclic carbene-based ruthenium-catalyzed direct amidation of aldehydes with amines
Cheng Chen, Min Ha Kim and Soon Hyeok Hong
Org. Chem. Front., 2015,2, 241-247
DOI: 10.1039/C4QO00319E, Research Article

Catalytic dehydrogenative aromatization: an alternative route to functionalized arenes
Simon A. Girard, Huawen Huang, Feng Zhou, Guo-Jun Deng and Chao-Jun Li
Org. Chem. Front., 2015,2, 279-287
DOI: 10.1039/C4QO00358F, Tutorial Account

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Two- and three-coordinate formal iron(I) compounds featuring monodentate aminocarbene ligands
Zhenbo Mo, Zhenwu Ouyang, Lei Wang, Kathlyn L. Fillman, Michael L. Neidig and Liang Deng
Org. Chem. Front., 2014, Advance Article
DOI: 10.1039/C4QO00175C, Research Article

Generation of 1-amino-isoquinoline-N-oxides via a tandem reaction of 2-alkynylbenzaldoxime with secondary amines in the presence of silver(I) and copper(I)
Junjie Song, Congbin Fan, Gang Liu and Guanyinsheng Qiu
Org. Chem. Front., 2014, Advance Article
DOI: 10.1039/C4QO00209A, Research Article

Facile solid-phase synthesis of PNA–peptide conjugates using pNZ-protected PNA monomers
Yi-Chao Huang, Cheng Cao, Xiang-Long Tan, Xiaoyu Li and Lei Liu
Org. Chem. Front., 2014, Advance Article
DOI: 10.1039/C4QO00217B, Research Article

A sidearm-assisted phosphine for catalytic ylide intramolecular cyclopropanation
Jian-Bo Zhu, Hao Chen, Saihu Liao, Yu-Xue Li and Yong Tang
Org. Chem. Front., 2014, Advance Article
DOI: 10.1039/C4QO00232F, Research Article

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