Archive for the ‘EMI’ Category

Emerging Investigator: Michael C. Young at the University of Toledo

Emerging Investigator: Michael C. Young

Position          Associate Professor

Postdoc          2014–2016  University of Texas at Austin

Education       2009–2014  University of California, Riverside          Ph.D.

                       2006–2008  Western Carolina University                   M.Sc.

                       2003–2006  Western Carolina University                   B.Sc.

ORCID            0000-0002-3256-5562                      Google Scholar

Read Michael C. Young’s Emerging Investigator Series article in Organic Chemistry Frontiers and learn more about him.

     
  Oxidative Mizoroki–Heck reaction of unprotected cinnamylamines at ambient temperature under air  

 

Cinnamylamines make-up many important drugs that target G protein-coupled receptors.

 

  From the themed collection: OCF Emerging Investigator Series  
  The article was first published on 04 Jul 2023  
  Org. Chem. Front., 2023, 10, 3982-3988  
  https://doi.org/10.1039/D3QO00778B  
     

My research interests

Key words: sustainability, organometallics, drug discovery, catalyst design, synthetic methodology
Michael Young’s research focuses on developing new synthetic methods to expedite chemical synthesis of biologically active molecules. A unifying theme of his group is to incorporate sustainability in everything they do, either through developing more efficient chemical processes, reducing the use of hazardous reagents, or developing more active catalysts. His group is interested in everything from designing new catalysts, to demonstrating their synthetic utility, to collaborating to determine the activity of all newly developed compounds with a particular focus on treatments for opioid use disorders. 

10 Facts about me

When I was a kid, I already wanted to become a researcher, though my first interest was in brain-computer interfaces.

If I weren’t a scientist, I’d probably be a musician, specifically a composer/performer. My favourite instrument is the F horn.

I try to impress upon my students the value of creating and exploring their own research ideas and interests as students. Graduate school may not be the best compensated time, but it is the freest to explore new ideas.

If I could go back to graduate school, I would work with someone in the directed protein evolution field. Biocatalysis can do so many cool things that synthetic chemists are trying, but mostly failing, to replicate.

My favourite reaction is the Ireland-Claisen rearrangement. It helped me to solve a challenging product synthesis that I could not achieve through other means.

My favourite metal is molybdenum, even though we don’t work with it at the moment.

My favourite book is Brave New World by Aldous Huxley. I enjoy dystopian literature, although perhaps less as some of these works begin to feel more prescient than fictitious.

I enjoy listening to video game sound tracks. I find it helps to focus while I’m writing grant proposals or manuscripts.

I am happiest when I am surrounded by mountains.

My biggest goal as a researcher is to do something so off-the-wall that my group earns an Ig Nobel Prize.

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Emerging Investigator: Liang-An Chen at Nanjing Normal University, China

Emerging Investigator: Liang-An Chen

Position          Professor

Education       2011–2014  Xiamen University                            Ph.D.

                       2008–2011  Xiamen University                            M.Sc.

                       2004–2008  Fuyang Normal University                B.Sc.

ORCID            0000-0003-3423-3390

Read Liang-An Chen’s Emerging Investigator Series article in Organic Chemistry Frontiers and learn more about him.

     
  Redox-active alkyl xanthate esters enable practical C–S cross-coupling by nickel catalysis  

 

A new nickel catalysis strategy that harnesses readily accessible alkyl xanthate esters, while previously well-studied as alkyl radical precursors, herein as ideal sulfenylating agents via an unprecedented C–S bond activation pattern.

 

  From the themed collection: OCF Emerging Investigator Series  
  The article was first published on 11 Apr 2023  
  Org. Chem. Front., 2023, 10, 2505-2516  
  https://doi.org/10.1039/D3QO00136A  
     

My research interests

Key words: asymmetric catalysis, diene chemistry, alkene difunctionalization, oxidative cyclization, radical chemistry
My current research interests focus on methodology development, aiming to achieve transition metal-catalyzed asymmetric conjugated dienylation of propargyl alcohol derivatives (PADs) in a high regio-, chemo- and stereoselective manner and to explore their application in the development of new functionalization reactions based on the two conjugated C–C bonds. 

10 Facts about me

My favorite time of the day is the morning because I can enjoy reading the ASAP articles or the tweets on the public accounts.

What I look for first in a paper are insightful thoughts and challenges in the area.

If I were not an organic chemistry professor, I would be a historian or soldier.

In my spare time, I love playing games and sports with my two sons and traveling with my family.

The most difficult challenges I have faced were starting my independent research career and establishing an innovative and unique research program.

The first academic article I published in my independent research career is in Angewandte Chemie. This paper shaped the research interests of my group.

The most challenging work in my research is to achieve the asymmetric 1,3-dienylation of PADs with different carbon-based nucleophiles with high selectivity.

My advice for younger students is that hard work, persistence, strong will, and thinking more independently are key to success in their beginning research career.

An accomplishment I’m particularly proud of is that my students have become who they want to be after graduation.

The next goal of my research is to achieve structurally diverse conjugated dienes from PADs and to explore their further application in the synthesis of complex molecules with industrial needs.

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Emerging Investigator: Guangfan Zheng at Northeast Normal University, China

Emerging Investigator: Guangfan Zheng

Position          Associate Professor

Education       2014–2017  Northeast Normal University                Ph.D.

                       2012–2014  Northeast Normal University                M.Sc.

                       2006–2010  Jilin University                                      B.Sc.

ORCID            0000-0003-0201-6279

Read Guangfan Zheng’s Emerging Investigator Series article in Organic Chemistry Frontiers and learn more about him.

     
  Visible light-mediated NHC and photoredox co-catalyzed 1,2-sulfonylacylation of allenes via acyl and allyl radical cross-coupling  

 

Visible light-mediated NHC and photoredox co-catalyzed radical 1,2-sulfonylacylation of allenes via cross-coupling between an allyl radical and an NHC-stabilized acyl radical.

 

  From the themed collection: Frontiers Emerging Investigator Series  
  The article was first published on 03 Jan 2023  
  Org. Chem. Front., 2023, 10, 1047-1055  
  https://doi.org/10.1039/D2QO01993K  
     

My research interests

Key words: NHC catalysis, radical chemistry, cascade reaction, asymmetric catalysis, photocatalysis
My research interests focus on the development of N-heterocyclic carbene (NHC)-catalyzed, or visible light-mediated novel radical transformation, cascade reactions and asymmetric catalytic reactions. Particularly, we aim to develop efficient and highly selective catalytic transformation of aldehyde or carboxylic acid derivatives (such as carboxylic acid, ester, acyl fluoride, or amides) accessing value-added chemicals. 

10 Facts about me

When I was a kid, I wanted to be a scientist, as I enjoy new discoveries and challenges.

I published my first academic article in 2015 during my PhD studies in Nature Communications. This article demonstrates interesting and unpredictable N-centered radical addition to alkyne-initiated cascade transformations realizing animative muti-functionalization of alkynes.

The most challenging work about my research is to realize efficient asymmetric induction in NHC-catalyzed radical–radical cross-couplings.

In my spare time, I enjoy reading online novels.

My favorite science fiction novel is The Three-Body Problem.

The person who has had the greatest influence on my research career is my M.S. and Ph.D. supervisor Prof. Qian Zhang (Northeast Normal University). She was passionate about scientific research and was very inspiring.

The most important qualities of a role model are honesty, patience, and responsibility.

The most important thing I have learned is that opportunities are for those who are prepared.

I advise my students to keep enthusiasm and individual thinking about their research.

I lose track of time when discussing research progress and prospects with students.

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Emerging Investigator: Meng Li from Institute of Chemistry, Chinese Academy of Sciences (ICCAS)

Emerging Investigator: Meng Li

Position          Associate Professor

Education       2012–2015  Institute of Chemistry, CAS                Ph.D.

                       2009–2012  University of Chinese Academy of Sciences                                                                                                          M.Sc.

                       2005–2009  Shandong Normal University              B.Sc.

ORCID            0000-0003-4835-9293

Read Meng Li’s Emerging Investigator Series article in Organic Chemistry Frontiers and learn more about him.

     
  Advances in circularly polarized electroluminescence based on chiral TADF-active materials  

 

This review summarizes the development status of chiral TADF-active materials with CPEL, covering chiral perturbed TADF molecules, intrinsically chiral TADF molecules, and TADFsensitized fluorescent enantiomers.

 

  From the themed collection: Frontiers Emerging Investigator Series  
  The article was first published on 24 Sep 2022  
  Org. Chem. Front., 2022, 9, 6441-6452  
  https://doi.org/10.1039/D2QO01383E  
     

My research interests

Key words: organic synthesis, circularly polarized luminescence, organic light-emitting diodes
Meng Li’s research focuses on developing chiral optoelectronic materials for photoelectric conversion devices. He is also interested in understanding the structure–activity relationship between chiral molecules and their circularly polarized luminescence properties, as well as developing circularly polarized organic light-emitting diodes for display device of low power consumption. 

10 Facts about me

My favourite published academic article is the one on circularly polarized electroluminescence (CPEL) materials in Angew. Chem. Int. Ed. in 2018. In this work, we created a new system of CPEL materials based on chiral thermally activated delayed fluorescence (TADF) materials, providing an original research idea to solve the key problem of low device efficiency in the field of CPEL materials.

The academic group that helped me most is the Youth Innovation Promotion Association CAS. The members of this academic group are all outstanding young scientists under the age of 35 in CAS. They are active in various academic fields, and are ready to help others. Becoming a member of the group has greatly helped my scientific research.

The most important questions to be asked/answered in my research field include: (1) How to design and construct chiral luminescent materials with large asymmetry factor and high efficiency? (2) How to realize the transfer, amplification and regulation of chiral optoelectronic properties with multi-level chiral structures? (3) How to realize the creation of high-performance circularly polarized light emitting devices?

The most challenging work about my research is the application of chiral luminescent materials. I think this will require interdisciplinary collaborations between different academic fields, partnerships with industrial stakeholders, etc.

If I were not a scientist, I would be a secondary school teacher.

In my spare time, I enjoy reading biographical novels and playing Chinese chess.

One piece of career-related wisdom I would like to share with other early career scientists: be passionate about your research, and keep your curiosity.

The next big goal of my research is to improve the asymmetry factor of circularly polarized electroluminescence of chiral TADF-active materials.

My favourite book is Journey to the West.

My favourite time of the day is on the way to work in the morning. At that time, I am full of expectations for the whole day’s experiments.

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