Subject: Hear from our authors: Shanka Walia and Mohit J. Mehta

RSC Pharmaceutics has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Shanka Walia and Mohit J. Mehta about their study titled “Recent Progress on Nanosystems for Nucleic Acid Delivery.”

 

“The review provides a comprehensive overview of the use of nanocarriers for the delivery of nucleic acid-based therapeutics. We have discussed the challenges associated with the delivery of nucleic acids, such as their instability, degradation, and inefficient delivery to target cells. The review not only highlights these challenges but also presents a beacon of hope in the form of the potential of lipid-based delivery systems to overcome them. We have discussed various types of lipid-based nanocarriers, including cationic lipids, ionizable lipids, zwitterionic lipids, lipid nanoparticles (LNPs), liposomes, and solid lipid nanoparticles (SLNs). The review also discusses the advantages and disadvantages of each type of nanocarrier. Finally, we have concluded the review by emphasizing the potential of lipid-based nanocarriers to revolutionize the field of nucleic acid therapeutics, inspiring a sense of optimism and anticipation among our readers.

The most exciting aspect of this research is the potential of lipid-based nanocarriers to revolutionize the field of nucleic acid therapeutics. This potential is not just promising, but it’s a game-changer. We have highlighted the many advantages of these nanocarriers, such as their ability to protect nucleic acids from degradation, enhance their cellular uptake, and target them to specific cells and tissues. We have also discussed the recent successes of lipid-based nanocarriers in developing mRNA vaccines for COVID-19. The potential impact of this work is significant. Lipid-based nanocarriers have the potential to enable the development of new and more effective treatments for various diseases, including cancer, genetic disorders, and infectious diseases. Our review provides a valuable overview of the current state of the field. It highlights the challenges that need to be overcome to fully realize the potential of lipid-based nanocarriers.”

 

Want to know more about their work? Read the full paper here!

Graphical abstract: Recent progress on nanosystems for nucleic acid delivery

 

Recent progress on Nanosystems for Nucleic Acid Delivery

Shanka Walia and Mohit J. Mehta

RSC Pharm. 2024, Advance Article, DOI: https://doi.org/10.1039/D4PM00009A

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

 

RSC Pharmaceutics – Issue 2 now online

We are delighted to share Issue 2 of RSC Pharmaceutics. Read our new open access journal, publishing crucial research on pharmaceutics, which has the potential to drive real change in worldwide health.

“RSC Pharmaceutics will provide a platform for researchers to showcase their best work in this field and contribute to the advancement of Pharmaceutics. I look forward to promoting this journal and its published research to the community.”

Yvonne Perrie, Editor-in-Chief, RSC Pharmaceutics

Our second issue includes:

Enhancement of drug permeation across skin through stratum corneum ablation

Ayyah Abdoh, David Liu and Yousuf Mohammed

RSC Pharm., 2024,1, 151-160

DOI: 10.1039/D4PM00089G

Polymer–drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer’s disease

Nuruddin Mahadik, Gemma A. Barron, Paul Kong Thoo Lin and Colin J. Thompson

RSC Pharm., 2024,1, 161-181

DOI: 10.1039/D3PM00075C

Advances of cassava starch-based composites in novel and conventional drug delivery systems: a state-of-the-art review

Sanjoy Das, Malay K. Das, Taison Jamatia, Bireswar Bhattacharya, Rishav Mazumder, Pradip Kumar Yadav, Nayan Ranjan Ghose Bishwas, Trinayan Deka, Dhritiman Roy, Bibek Sinha, Biplajit Das, Ichu Daule, Kishan Paul, Ankita Roy, Ankita Choudhury, Pinkan Sadhukhan, Dibyojyoti Sarmah, Dhritiman Bhargab, Bani Kumar Jana, Dubom Tayeng, Nilayan Guha, Bhrigumani Kalita and Subhajit Mandal

RSC Pharm., 2024,1, 182-203

DOI: 10.1039/D3PM00008G

Potential of ultrasonic processing in biomedical applications 

Siddhi Lokhande, Bhagyashree V. Salvi and Pravin Shende

RSC Pharm., 2024,1, 204-217

DOI: 10.1039/D4PM00010B

Synthetic mucus barrier arrays as a nanoparticle formulation screening platform 

Harry Zou, Allison Boboltz, Yahya Cheema, Daniel Song, Devorah Cahn and Gregg A. Duncan

RSC Pharm., 2024,1, 218-226

DOI: 10.1039/D3PM00057E

In vitro evaluation of microneedle strength: a comparison of test configurations and experimental insights 

Bilal Harieth Alrimawi, Jing Yi Lee, Keng Wooi Ng and Choon Fu Goh

RSC Pharm., 2024,1, 227-233

DOI: 10.1039/D4PM00024B

A model binary system for the evaluation of novel ion pair formulations of diclofenac 

Mignon Cristofoli, Jonathan Hadgraft, Majella E. Lane and Bruno C. Sil

RSC Pharm., 2024,1, 234-244

DOI: 10.1039/D4PM00063C

Green synthesis of silver nanoparticles using Phyllanthus emblica extract: investigation of antibacterial activity and biocompatibility in vivo

Md Monir Hossain, Amir Hamza, Shakil Ahmed Polash, Mehedi Hasan Tushar, Masato Takikawa, Anuj Bhowmik Piash, Chaitali Dekiwadia, Tanushree Saha, Shinji Takeoka and Satya Ranjan Sarker

RSC Pharm., 2024,1, 245-258

DOI: 10.1039/D3PM00077J

Novel alginate nanoparticles for the simultaneous delivery of iron and folate: a potential nano-drug delivery system for anaemic patients 

Weranga Rajapaksha, Irosha H. W. Nicholas, T. Thoradeniya, D. Nedra Karunaratne and V. Karunaratne

RSC Pharm., 2024,1, 259-271

DOI: 10.1039/D3PM00068K

Insight into the liposomal encapsulation of mono and bis-naphthalimides

Abdullahi Magaji Dauda, Thomas Swift, Richard Telford, Hend A. A. Abd El-wahab, Chhanda Charan Danta, Klaus Pors and Amalia Ruiz

RSC Pharm., 2024,1, 272-282

DOI: 10.1039/D3PM00060E

Synthesis and biological evaluation of novel hybrid compounds bearing pyrazine and 1,2,4-triazole analogues as potent antitubercular agents

Shivakumar Naik, Dinesha Puttachari, Vanishree A. L., Udayakumar D., Varsha Prakash Shetty, Chaitra Prabhu and Vijaya Kumar Deekshit

RSC Pharm., 2024,1, 283-295

DOI: 10.1039/D3PM00054K

Thermodynamic and spectroscopic evaluation of the eutectic mixture of myristic acid and the local anaesthetics, bupivacaine and ropivacaine

Priyanka Agarwal, Darren Svirskis and Michél K. Nieuwoudt

RSC Pharm., 2024,1, 296-304

DOI: 10.1039/D3PM00082F

Development of polyethyleneimine cross-linked fucoidan nanoparticles as delivery systems for improved anticancer efficiency of cytarabine in breast adenocarcinoma cell lines

Deepa Geethakumari, Santhini Pulikkal Veettil, Sivakumar Krishnankutty Nair Chandrika, Anoop Bhaskaran Sathyabhama, Rojin Joseph, Shibin Sobhanam Padmini, Jisha V. Somasekharan and Sajeevan Thavarool Puthiyedathu

RSC Pharm., 2024,1, 305-316

DOI: 10.1039/D3PM00078H

Biocompatible, injectable and self-healable MOF-based anti-freezing eutectogels for higher encapsulation and sustained release of the anticancer drug curcumin

Nildhara Parsana,a Hiral Ukani, Dharmveer Singh Chauhan, Omar El Seoud, Sanjay Mehra, Arvind Kumar, Naina Raje and Naved Malek

RSC Pharm., 2024,1, 317-332

DOI: 10.1039/D3PM00088E

Elucidation of processing parameters for the reverse engineering of tablets 

Devendra Choudhary, Dnyaneshwar Kalyane, Suryanarayana Polaka, Tanisha Gupta and Rakesh Kumar Tekade

RSC Pharm., 2024,1, 333-343

DOI: 10.1039/D3PM00058C

Evaluation of the anti-depressant potential of EGCG-loaded nanoparticles in unstressed and stressed mice

Shakti Dahiya, Ruma Rani, Neeraj Dilbaghi, Dinesh Dhingra, Sant Lal and Jaya Verma

RSC Pharm., 2024,1, 344-356

DOI: 10.1039/D3PM00022B

Novel pH-sensitive gum ghatti-cl-poly(acrylic acid) composite hydrogel based on graphene oxide for metformin hydrochloride and sodium diclofenac combined drug-delivery systems

Pragnesh N. Dave and Pradip M. Macwan

RSC Pharm., 2024,1, 357-371

DOI: 10.1039/D3PM00072A

Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins

Hendra Saputra, Muhammad Safaat, Kazuki Uchida, Pugoh Santoso, Rie Wakabayashi, Masahiro Goto, Toki Taira and Noriho Kamiya

RSC Pharm., 2024,1, 372-378

DOI: 10.1039/D3PM00087G

These articles and our future publications are free to access by anyone.

Start reading now

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

Sign up for email alerts and submit your manuscript.

Hear from our authors: Scott Mitchell

RSC Pharmaceutics has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

 

In this edition, we hear from Scott Mitchell about their study titled Acid- and base-resistant antimicrobial hydrogels based on polyoxometalates and chitosan.

 

“Only a few decades ago, antimicrobial resistance (AMR) was largely confined to hospitals and long-term care facilities, but over the last decade it has emerged as a serious global threat to public health. Furthermore, invasive fungal infections kill more than 1.7 million and affect over a billion people each year; however, their devastating impact on human health is not yet widely appreciated and is frequently neglected by public health authorities. In our group, we’ve used the naturally occurring polymer chitosan (CS) in combination with molecular polyoxometalates (POMs) to produce hybrid micro- and nano-capsules. Our hypothesis was that such nanostructured hybrid hydrogel materials could possess surface-active biocidal activity through additive and synergic effects. A series of pH resistance assays concluded that macroscopic hybrid hydrogels made from POMs and chitosan maintained their structural integrity after prolonged contact with both acidic and basic pH and that their potent surface-active antibiofilm properties against model bacterial strains (Gram-positive Bacillus subtilis and Gram-negative Escherichia coli) and airborne environmental moulds (Aspergillus niger and Cladosporium cladosporioides). Furthermore, the antimicrobial activity of the hydrogels could be enhanced through the inclusion of naturally occurring antimicrobial agents such as eugenol and cinnamaldehyde into the polymeric matrix.”

 

“Although we anticipated some form of antifungal activity, we didn’t anticipate these hybrid POM@CS hydrogels to perform so well in these preliminary tests against moulds. So, modulating this synergistic activity and improving the specificity towards certain strains is something that we’re really excited about.”

 

“The most challenging aspect was probably related to the transfer of synthetic procedures used to make the materials from one researcher to another. The project was initiated by Isabel Franco (a doctoral researcher) and Andrés Seral (a postdoctoral researcher), both of whom found positions in industry and academia after their contracts ended. This meant they had to transfer the synthetic protocols to Callum McWilliams (an Erasmus student from University of Glasgow) who completed the work during his research project in Zaragoza. Although it wasn’t an ideal scenario, we now know that the synthetic protocols are highly reproducible from one person to another and that’s definitely a positive outcome.”

 

“Ultimately, we hope that such synergic approaches could help to prevent the appearance of resistances. These hydrogels could easily be employed in health settings, as wound healing patches or poultices. However, there are many other instances where microbial colonization must be treated or avoided and where the appearance of resistances is troubling, e.g., biofilm build-up and blockages in water purification systems or microbiologically-influenced corrosion of engineered structures.”

 

Want to know more about their work? Read the full paper here!

Acid- and base-resistant antimicrobial hydrogels based on polyoxometalates and chitosan

Callum McWilliams, Isabel Franco-Castillo, Andrés Seral Ascaso, Sonia García-Embid, Mariella Malefioudaki, Johann G. Meier, Rafael Martín-Rapún and Scott G. Mitchell

RSC Pharm. 2024, Advance Article, DOI: 10.1039/D4PM00062E

 

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

 

Hear from our authors: Noriho Kamiya

RSC Pharmaceutics has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

 

In this edition, we hear from Noriho Kamiya about their study titled Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins.

 

“This study follows on from our previous work (ACS Infect. Dis., 2022, 8, 1051-1061). In our attempts to enhance the function of antifungal proteins by artificial lipid modification, we have obtained new evidence that specific lengths of lipid moieties enhance the antifungal activity of the chitin-binding domain of a plant chitinase in the presence of amphotericin B. Further studies, including the development of new formulations that maximize the potent antifungal properties, are underway.”

 

Want to know more about their work? Read the full paper here!

Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins

Hendra Saputra, Muhammad Safaat, Kazuki Uchida, Pugoh Santoso, Rie Wakabayashi, Masahiro Goto, Toki Taira and Noriho Kamiya

RSC Pharm. 2024, Advance Article, DOI: 10.1039/D3PM00087G

 

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

 

Hear from our authors: Venkatesh Ravula

RSC Pharmaceutics has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

 

In this edition, we hear from Venkatesh Ravula about their Review titled Phenylboronic acid-derived nanovectors for gene/drug delivery by targeting cell surface glycans.

 

Want to know more about their work? Read the full paper here!

Phenylboronic acid-derived nanovectors for gene/drug delivery by targeting cell surface glycans

Venkanna Muripiti, Venkatesh Ravula, Srinivas Batthula, Janardhan Banothu and Ramesh Gondru

RSC Pharm. 2024, Advance Article, DOI: 10.1039/D4PM00005F

 

 

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

 

Explore the first issue of RSC Pharmaceutics

RSC Pharmaceutics: the inaugural issue

 

We are proud to present the very first issue of RSC Pharmaceutics, the gold open access journal publishing work with the potential to drive real change in worldwide health.

Read on for innovative research dedicated to advancing the fields of drug delivery, formulation, and pharmaceutical technology.

Start reading issue one here.

 

“I look forward to seeing first-hand the future of this field and feel honoured to play a role in supporting authors to share their research.”
Yvonne Perrie
Editor-in-Chief

 

Our first issue includes…

 

Introducing RSC Pharmaceutics

Yvonne Perrie

RSC Pharm., 2024, 1, 8, DOI: 10.1039/D4PM90001D

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Mohit Kumar, Devesh Kumar, Syed Mahmood, Varinder Singh, Shruti Chopra, Ayah R. Hilles and Amit Bhatia

RSC Pharm., 2024, 1, 9-36, DOI: 10.1039/D3PM00024A

 

 

Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo

Mathieu Varache, Siân Rizzo, Edward J. Sayers, Lucy Newbury, Anna Mason, Chia-Te Liao, Emilie Chiron, Nathan Bourdiec, Adam Jones, Donald J. Fraser, Philip R. Taylor, Arwyn T. Jones, David W. Thomas and Elaine L. Ferguson

RSC Pharm., 2024, 1, 68-79, DOI: 10.1039/D3PM00014A

 

Cerium oxide particles: coating with charged polysaccharides for limiting the aggregation state in biological media and potential application for antibiotic delivery

Cléa Chesneau, André Pawlak, Séna Hamadi, Eric Leroy and Sabrina Belbekhouche

RSC Pharm., 2024, 1, 98-107, DOI: 10.1039/D3PM00081H

 

 

 

In vitro anti-trypanosomal activity of 3-(aryl)-6-piperazin1,2,4-triazolo[3,4-a]phthalazines-loaded ultrathin polymeric particles: effect of polymer type and particle size

Karina González, Ender Medina, Elena Aguilera, Gema González, Marcos A. Sabino and Angel H. Romero

RSC Pharm., 2024, 1, 108-120, DOI: 10.1039/D3PM00002H

 

Molecular structure of ketoprofen-polyvinylpyrrolidone solid dispersions prepared by different amorphization methods

Stephen K. Wilke, Chris J. Benmore, Vrishank Menon, Dan Smith, Stephen R. Byrn and Richard Weber

RSC Pharm., 2024, 1, 121-131, DOI: 10.1039/D3PM00038A

 

RSC Pharmaceutics is leading the way in drug delivery, formulation and pharmaceutical technology.
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3rd South Florida Translational Research Symposium – RSC Pharmaceutics Poster Prize Winners

The 3rd South Florida Translational Research Symposium took place at Florida International University, USA, on the 11th and 12th of April 2024. The symposium featured highly relevant plenary talks in neuroscience, drug discovery and delivery, healthy aging and cardiopulmonary. Our RSC Pharmaceutics Editorial Member, Dr Heidi Mansour attended this conference, and RSC Pharmaceutics was lucky enough to sponsor three prizes for the undergraduate, post graduate and postdoctoral poster winners!

 

(left) Undergraduate poster winner, Victoria Clark, Florida International University; (middle) Graduate poster winner, Eman Taher, Florida International University; (right) Postdoctoral poster winner, Ngozi Patience Paul, Florida International University

Undergraduate poster winner: Victoria Clark (Florida International University)

Graduate poster winner: Eman Taher (Florida International University)

Postdoctoral poster winner: Ngozi Patience Paul (Florida International University)

We are delighted that the conference was such a success and we would like to wish a huge congratulations to the poster prize winners!

 

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

Sign up for email alerts and submit your manuscript.

Hear from our authors: Eva Kudová, Stanislav Chvíla and František Štěpánek

RSC Pharmaceutics recently published its first articles, which can be read for free here. To celebrate publishing our first articles, we asked some of our authors to discuss their work in more detail.

In this post, we hear about the research from Chvíla et al. in their article titled “A zuranolone nanocrystal formulation enables solubility-independent in vivo study of pentylenetetrazol-induced seizures in a rat model”. Watch three of the authors, Eva Kudová, Stanislav Chvíla and František Štěpánek, talk about their work below or here!

A zuranolone nanocrystal formulation enables solubility-independent in vivo study of pentylenetetrazol-induced seizures in a rat model

Stanislav Chvíla, Hana Kubová, Pavel Mareš, Eva Kudová and František Štěpánek

RSC Pharm., 2024, Advance Article.

DOI: 10.1039/D3PM00043E

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

Sign up for email alerts and submit your manuscript.

 

RSC Pharmaceutics – first articles now online

Explore the first articles from RSC Pharmaceutics

We are delighted to share the first articles from RSC Pharmaceutics. Our new journal publishes crucial research on pharmaceutics, which has the potential to drive real change in worldwide health. Every article is gold open access, so you can read and be inspired for free.

Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo

Mathieu Varache, Siân Rizzo, Edward J. Sayers, Lucy Newbury, Anna Mason, Chia-Te Liao, Emilie Chiron, Nathan Bourdiec, Adam Jones, Donald J. Fraser, Philip R. Taylor, Arwyn T. Jones, David W. Thomas and Elaine L. Ferguson

RSC Pharm., 2024, Advance Article,
DOI: 10.1039/D3PM00014A

Indocyanine green within glycosylated polymeric micelles as potential image agents to map sentinel lymph nodes and breast cancer

Nicole Lecot, Marcelo Fernández-Lomónaco, Hugo Cerecetto, Juan Pablo Gambini, Pablo Cabral and Romina Glisoni

RSC Pharm., 2024, Advance Article,
DOI: 10.1039/D3PM00053B

A zuranolone nanocrystal formulation enables solubility-independent in vivo study of pentylenetetrazol-induced seizures in a rat model

Stanislav Chvíla, Hana Kubová, Pavel Mareš, Eva Kudová and František Štěpánek

RSC Pharm., 2024, Advance Article,
DOI: 10.1039/D3PM00043E

These articles and our future publications are free to access by anyone.

Start reading now

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

Sign up for email alerts and submit your manuscript.

Meet our Associate Editor, Heidi Mansour

We are delighted to introduce you to our new RSC Pharmaceutics Associate Editor, Heidi Mansour.

Dr. Mansour is currently a Professor and Program Leader of Drug Discovery and Delivery at the Florida International University (FIU) Center for Translational Science located in Port Saint Lucie, Florida, on the beautiful Treasure Coast.

Read more about Professor Mansour here.

Read some of Professor Mansour’s research here:

Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release
David Encinas-Basurto, John P. Konhilas, Robin Polt, Meredith Hay and Heidi M. Mansour
Pharmaceutics, 2022, 14, 587.

Advanced design and development of nanoparticle/microparticle dual-drug combination lactose carrier-free dry powder inhalation aerosols
Priya Muralidharan, Evan K. Mallory, Monica Malapit, Hanna Phan, Julie G. Ledford, Don Hayes, Jr and Heidi M. Mansour
RSC Adv., 2020, 10, 41846-41856.

Microparticulate/nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway
Priya Muralidharan, Don Hayes, Jr., Stephen M. Black and Heidi M. Mansour
Mol. Syst. Des. Eng., 2016, 1, 48-65.

RSC Pharmaceutics is a new gold open access journal from the Royal Society of Chemistry and publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. This journal is now open for submissions.