RSC Pharmaceutics – Issue 5

We are delighted to share Issue 5 of RSC Pharmaceutics. Read our new open access journal, publishing crucial research on pharmaceutics, which has the potential to drive real change in worldwide health.

“RSC Pharmaceutics will provide a platform for researchers to showcase their best work in this field and contribute to the advancement of Pharmaceutics. I look forward to promoting this journal and its published research to the community.”

Yvonne Perrie, Editor-in-Chief, RSC Pharmaceutics

 

Here are a few of the articles featured in our fifth issue:

 

Graphical abstract: Nano-steps in altered opioid pharmacokinetics: a perspective on potential drug delivery post-bariatric surgery applications

Nano-steps in altered opioid pharmacokinetics: a perspective on potential drug delivery post-bariatric surgery applications

A. E. Avanu, A. M. Ciubotariu, A. M. Ciornei, A. D. Cozmîncă and G. Dodi*

RSC Pharm., 2024,1, 864-878

https://doi.org/10.1039/D4PM00187G

 

 

 

 

 

Graphical abstract: Reconceptualising mucoadhesion for future medicines

Reconceptualising mucoadhesion for future medicines

Michael T. Cook* and David Shorthouse

RSC Pharm., 2024,1, 949-957

https://doi.org/10.1039/D4PM00149D

 

 

 

 

 

Graphical abstract: Increased thermal stability and retained antibacterial properties in a sulbactam and amantadine salt: towards effective antibacterial–antiviral combination therapies

Increased thermal stability and retained antibacterial properties in a sulbactam and amantadine salt: towards effective antibacterial–antiviral combination therapies

Josephine Bicknell, Ivan Bondarenko, Alice Colatrella, Elani J. Cabrera-Vega, Jesus Daniel Loya,  Delbert S. Botes, Jay L. Mellies and Gonzalo Campillo-Alvarado

RSC Pharm., 2024,1, 958-962

https://doi.org/10.1039/D4PM00247D

 

 

 

Graphical abstract: Prodrug nanotherapy demonstrates in vivo anticryptosporidial efficacy in a mouse model of chronic Cryptosporidium infection

Prodrug nanotherapy demonstrates in vivo anticryptosporidial efficacy in a mouse model of chronic Cryptosporidium infection

Amalendu P. Ranjan, Daniel J. Czyzyk, Griselle Martinez-Traverso, Aygul Sadiqova, Margarita Valhondo, Deborah A. Schaefer, Krasimir A. Spasov, William L. Jorgensen, Jamboor K. Vishwanatha, Michael W. Riggs, Alejandro Castellanos-Gonzalez and Karen S. Anderson

RSC Pharm., 2024,1, 963-975

https://doi.org/10.1039/D4PM00093E

 

 

 

Graphical abstract: Structure–activity relationships of DNA nanocarriers based on the amphipathic cell penetrating peptide transportan 10

Structure–activity relationships of DNA nanocarriers based on the amphipathic cell penetrating peptide transportan 10

Lucas Rodrigues de Mello, Tâmisa Seeko Bandeira Honda, Sang Won Han, Valeria Castelletto, Ian William Hamley, Ly Porosk, Ülo Langelcd and Emerson Rodrigo da Silva

RSC Pharm., 2024,1, 976-993

https://doi.org/10.1039/D4PM00065J

 

 

 

 

These articles and our future publications are free to access by anyone.

Start reading now

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

Sign up for email alerts and submit your manuscript.

Introducing Andy Lewis, Yahya Choonara, Dimitrios Lamprou, Raju Vivek, Lingling Shen and Hitesh Kulhar to our inaugural Advisory Board

We are very excited to introduce you to Andy Lewis, Yahya Choonara, Dimitrios Lamprou, Raju Vivek, Lingling Shen and Hitesh Kulhar as part of the inaugural Advisory Board for RSC Pharmaceutics!

Phots of PM advisory board

Dr Andy Lewis is Chief Scientific Officer, Quotient Sciences, UK. He has over 20 years experience working in the pharmaceutical and biotech industry focussed on advanced drug delivery technologies particularly protein and peptide drug delivery, solubility enhancement and controlled release.

“I look forward to joining the Advisory Board for the new RSC Pharmaceutics journal and supporting its development into a world leading journal for pharmaceutical scientists. As it’s a Gold Open Access journal researchers publishing in it can be confident of a wide dissemination of their work to help build their reputation.”- Dr Andy Lewis

Professor Yahya Choonara is part of Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology in the School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand located in Johannesburg, South Africa.

“I am pleased to serve on the Advisory Board of RSC Pharmaceutics which is a top-tier platform for advancing the frontier of pharmaceutical innovation and communicating the latest science in drug delivery, formulation, and discovery. The journal provides a vibrant and inclusive space for scientists from diverse backgrounds to share ideas, challenge assumptions, and shape the future of pharmaceutical science for the betterment of global health” – Professor Yahya. Choonara

Professor Dimitrios Lamprou is a Full Professor (Chair) of Biofabrication and Advanced Manufacturing and Director at MSc Industrial Pharmaceutics at Queen’s University Belfast School of Pharmacy. He is also the Chair at United Kingdom and Ireland Controlled Release Society (UKICRS), Committee Member of the British Standards Institute (BSI) AMT/8 for Additive Manufacturing, and Visiting Professor in a number of international Institutions

“I am very familiar with the Royal Society of Chemistry(RSC) journals and values, is an honour to be part of this family. With this appointment, I will be able to further support the journal, weed out low-quality contributions, guarantee the calibre of the articles that are published, and, at the same time, boost the topic. Pharmaceutics is an important field and this new journal will bring research more visual to researchers in the field by bringing fundamental and advanced research to them, supporting the development of advanced Drug Delivery Systems (DDSs)”.– Professor Dimitrios Lamprou

Dr. Raju Vivek is an Assistant Professor of Bharathiar University located in India.

“I am thrilled to be a part of the advisory board for RSC Pharmaceutics, a platform that showcases cutting-edge research in the field of pharmaceutics. As a member of the board, I am excited to contribute to the publication of innovative studies that will shape the future of pharmaceutical research. RSC Pharmaceutics is dedicated to highlighting novel discoveries and advancements in pharmaceutics, with a focus on high-potential therapeutics research. I look forward to working with the team to establish the journal as a leading voice in the field and to fostering the sharing of groundbreaking ideas and findings”– Dr. Raju Vivek

Dr Lingling Shen, is an Associate Director of Data Science and Discovery Sciences at Novartis Biomedical Research.

“RCS Pharmaceutics aims to be the ideal platform for all researchers including those from the industry, to share their work, even with confidentiality constraints. I’m excited about the journal’s supportive and efficient publishing process and hopeful it will grow to become a leading publication in the field.” – Dr Lingling Shen

Dr. Hitesh Kulhar is part of the School of Nano Sciences at the Central University of Gujarat located in Gandhinagar, India

“It is a privilege to be a part of the Royal Society of Chemistry (RSC) which is one of the oldest research and scientific communities and the subject of Pharmaceutics is close to my heart. So, I feel honored and delighted to be part of RSC Pharmaceutics.

RSC Pharmaceutics is a unique forum to provide communication between pharmaceutical formulation researchers, scientists and industries. It will showcase the research advances made in the areas of drug delivery, drug targeting and precision medicines.” – Dr. Hitesh Kulhar

 

RSC Pharmaceutics is a new gold open access journal from the Royal Society of Chemistry and publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. This journal is open for submissions.

Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest news by following us on LinkedIn. You can also keep informed by signing up to our E-Alerts.

 

 

Introducing Scott Mitchell, Sara Cordeiro, Twan Lammers, Eliana Lima, Avi Schroeder and Faisal Razato our inaugural Advisory Board

We are thrilled to introduce you to Scott Mitchell, Sara Cordeiro, Twan Lammers, Eliana Lima, Avi Schroeder and Faisal Razato as part of our inaugural RSC Pharmaceutics Advisory Board!

Photographs of PM advisory board group

Dr Scott Mitchell is from the Aragón Nanoscience and Materials Institute (INMA), Spanish National Research Council (CSIC) in Spain.

“The Royal Society of Chemistry has a track record of opening new avenues to disseminate transdisciplinary research. Health research containing elements of synthetic and analytical chemistry, materials design, nanoformulation, and interaction of drug delivery systems with biological models requires a dedicated space in the academic publishing ecosystem. I hope to provide insights that can help the RSC Pharmaceutics editors enhance this offering and attract high-quality submissions in this particular area.” – Dr Scott Mitchell

Dr Ana Sara Cordeiro is from the Leicester School of Pharmacy at De Montfort University in Leicester, UK.

“I am excited to join the Advisory Board for RSC Pharmaceutics, which is bound to become of the reference journals in our field. Interdisciplinarity is key to achieve real impact in improving healthcare and patients’ lives, and the intersection between drug chemistry and formulation design continues to be essential in the overall pharmaceutical development process. RSC Pharmaceutics is the perfect home for the top studies advancing knowledge in this field, and I am delighted to contribute to this journal at this point in its journey.”- Dr Ana Sara Cordeiro

Professor Twan Lammers is from the Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging,in the Center for Biohybrid Medical Systems at RWTH Aachen University Clinic, located in Aachen, Germany

Professor Eliana Lima is from the Universidade Federal de Goias  in Brazil

“I am excited to be part of RSC Pharmaceutics, as it represents a unique opportunity to connect with a global community dedicated to advancing pharmaceutical science. The journal is committed to publishing high-quality research that addresses current challenges and innovations in the field, offering a platform for impactful discoveries, fostering collaboration, and ensuring rigorous peer review to maintain scientific excellence.” – Professor Eliana Lima

Professor Avi Schroeder is from Technion at the Israel Institute of Technology.

Dr. Faisal Raza is from the School of Pharmacy at the Shanghai Jiao Tong University located in Shanghai, China.

“I am thrilled to join the Advisory Board of RSC Pharmaceutics because it aligns perfectly with my passion for advancing the field of pharmaceutics. Publishing in this journal offers the unique benefit of high visibility and accessibility, given its gold open access model. Researchers should consider submitting their work to RSC Pharmaceutics for its commitment to scientific excellence and its supportive editorial team.”– Dr Faisal Raza

 

RSC Pharmaceutics is a new gold open access journal from the Royal Society of Chemistry and publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. This journal is open for submissions.

Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest news by following us on LinkedIn. You can also keep informed by signing up to our E-Alerts.

Introducing Naved Malek, Audra Stinchcomb, Priyabrata Mukherjee, Wilson Poon, Emily Day and Anthony Hickey to our inaugural Advisory Board

We are delighted to introduce you to Naved Malek, Audra Stinchcomb, Priyabrata Mukherjee, Wilson Poon, Emily Day and Anthony Hickey as part of our inaugural RSC Pharmaceutics Advisory Board!

Photos of Advisory Board members

Dr Naved Malek is an Associate Professor at the Ionic Liquids Research Laboratory in the Department of Chemistry at Sardar Vallabhbhai National Institute of Technology located in Surat, India.

“RSC journals come with scientific excellence, quality and are highly regarded across various scientific communities. RSC Pharmaceutics with its targeted audience can enhance the visibility and credibility of the work that meets high standards of scientific rigor and innovation in the field of drug delivery, formulation, and physicochemical and biological properties of drugs and their carriers.” – Professor Naved Malek

Professor Audra L. Stinchcomb is currently a Professor in the School of Pharmacy at the University of Maryland in Baltimore, USA.

“The Royal Society of Chemistry has a long history of high impact chemistry journals, so of course Pharmaceutics is an important addition to the collection.  I am pleased to be part of a journal focused on transparent peer review and the scientists who make a difference in bringing the world quality pharmaceuticals.” – Professor Audra L. Stinchcomb

Professor Priyabrata Mukherjee is a PHF-Presidential Professor and a Professor of Pathology at University of Oklahoma Health Sciences Center. He is also a Peggy and Charles Stephenson Endowed Chair of Laboratory Cancer Research, Senior Director for Research Partnership and Collaboration at the Stephenson Cancer Center and Co-Director of the Nanomedicine Program.

Dr Wilson Poon is an Assistant Professor in the Department of Metallurgical, Materials and Biomedical Engineering at the University of Texas at El Paso

“I wanted to be involved with RSC Pharmaceutics because together, I think we can push the next generation of drug formulation and delivery science forward.”– Dr Wilson Poon

Dr Emily Day is currently an Associate Professor of Biomedical Engineering at the University of Delaware, in the USA.

I am excited to support RSC Pharmaceutics as this journal will provide a venue for researchers to share their most exciting work at the leading edge of drug development and delivery.”- Dr Emily Day

Professor Anthony Hickey is Professor Emeritus in the Eshelman School of Pharmacy and Adjunct Professor in the Department of Biomedical Engineering of the School of Medicine of The University of North Carolina at Chapel Hill.

RSC Pharmaceutics is a new forum addressing the demand for exchange of data, knowledge and ideas emerging from scientific and technological advances in novel therapeutic modalities, due to contemporary insights into the origins and mechanism of disease. Publications in the journal support the framework of understanding required to address the needs of disease therapy in the 21st Century.”- Professor Anthony Hickey

 

RSC Pharmaceutics is a new gold open access journal from the Royal Society of Chemistry and publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. This journal is open for submissions.

Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest news by following us on LinkedIn. You can also keep informed by signing up to our E-Alerts.

Introducing our inaugural Advisory Board

We are delighted to introduce our inaugural Advisory Board for RSC Pharmaceutics! Our Advisory Board is comprised of internationally renowned researchers working within the field of pharmaceutics.

Photos of Advisory Board members.

Please join us in welcoming our new Advisory Board members:

  • Andrew Lewis, Quotient Sciences, UK
  • Audra Stinchcomb, School of Pharmacy, University of Maryland, USA
  • Avi Schroeder, Technion, Israel Institute of Technology, Isreal
  • Dimitrios Lamprou, Queens University Belfast, Northern Ireland
  • Eliana Lima, Universidade Federal de Goias, Brazil
  • Faisal Raza, Shanghai Jiao Tong University, China
  • Lingling Shen, Novartis, USA
  • Priyabrata Mukherjee, University of Oklahoma Health Sciences Centre, USA
  • Raju Vivek, Bharathiar University, India
  • Scott Mitchell, Aragón Nanoscience and Materials Institute (INMA), Spain
  • Anthony Hickey, University of North Carolina at Chapel Hill, USA
  • Twan Lammers, RWTH Aachen University Clinic, Germany
  • Naved Malek, Sardar Vallabhbhai National Institute of Technology, India
  • Wilson Poon, University of Texas at El Paso, USA
  • Emily Day, University of Delaware, USA
  • Hitesh Kulhari, Central University of Gujarat, India
  • Yahya Choonara, University of the Witwatersrand, South Africa
  • Sara Cordeiro, Leicester School of Pharmacy, De Montfort University, UK

We are excited to welcome our new Advisory Board members to our journal community and look forward to working with them as we shape and grow the journal.

RSC Pharmaceutics is a new gold open access journal from the Royal Society of Chemistry and publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. This journal is open for submissions.

Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest news by following us on LinkedIn. You can also keep informed by signing up to our E-Alerts.

Meet our Editorial Board member, Arvind Kumar Bansal

We are delighted to introduce you to our new RSC Pharmaceutics Editorial Board member, Professor Arvind Kumar Bansal.

Professor Bansal is currently a Dean and Professor at the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research (NIPER) – SAS Nagar, Punjab, India.

I am honoured and excited for my new role as Editorial Board Member of RSC Pharmaceutics. The journal shall capture cutting-edge advancements in the diverse domains of drug delivery and pave the way for better medicines. I look forward to working with the highly accomplished editorial team.”

Read more about Professor Bansal here.

Read some of Professor Bansal’s research:

Study on Sulfamethoxazole–Piperazine Salt: A Mechanistic Insight into Simultaneous Improvement of Physicochemical Properties
Parag Roy, Soumalya Chakraborty, Noopur Pandey, Nimmy Kumari, Sourav Chougule, Amrita Chatterjee, Kaberi Chatterjee, Pallab Mandal, Bapi Gorain, Ananta V. Dhotre, Arvind Kumar Bansal, Animesh Ghosh
Molecular Pharmaceutics, 2023, 20, 5226-5239

Pharmaceutical nanocrystals: A promising approach for improved topical drug delivery
Prashantkumar K. Parmar, Jhanvi Wadhawan, Arvind K. Bansal
Drug Discovery Today, 2021, 10, 2329-2349

RSC Pharmaceutics is a new gold open access journal from the Royal Society of Chemistry and publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. This journal is now open for submissions.

Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest news by following us on LinkedIn. You can also keep informed by signing up to our E-Alerts.

2024 RNA Vaccines and Therapeutics Conference – RSC Pharmaceutics poster prize winners

Hosted by CPIImperial College London, and The BioIndustry Association (BIA), the second in the series of the RNA Vaccines and Therapeutics conference took place across 2‑days, bringing together a diverse range of experts from academia, biotech, pharma, and governmental and non-governmental agencies, with a mix of invited and abstract selected speakers together with a poster session.


The challenges and opportunities involved in developing and delivering the next generation of RNA medicines were discussed at length, and participants were able to hear from leading industry experts, share ideas, and build new connections within this rapidly advancing field.

RSC Pharmaceutics was delighted to support three poster prizes to celebrate the dedication of three researchers in the field, namely Jakub Hanczak (Imperial College London), Hadijatou Sallah (Imperial College London) and Piyush Chaturbedy (TTP plc).

RSC Pharmaceutics poster prize winner: Jakub Hanczak (Imperial College London)

RSC Pharmaceutics poster prize winner: Hadijatou Sallah (Imperial College London)

RSC Pharmaceutics poster prize winner: Piyush Chaturbedy (TTP plc)

The journal is delighted to provide support for this terrific work in such an important area of research.

Subject: Hear from our authors: Shanka Walia and Mohit J. Mehta

RSC Pharmaceutics has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Shanka Walia and Mohit J. Mehta about their study titled “Recent Progress on Nanosystems for Nucleic Acid Delivery.”

 

“The review provides a comprehensive overview of the use of nanocarriers for the delivery of nucleic acid-based therapeutics. We have discussed the challenges associated with the delivery of nucleic acids, such as their instability, degradation, and inefficient delivery to target cells. The review not only highlights these challenges but also presents a beacon of hope in the form of the potential of lipid-based delivery systems to overcome them. We have discussed various types of lipid-based nanocarriers, including cationic lipids, ionizable lipids, zwitterionic lipids, lipid nanoparticles (LNPs), liposomes, and solid lipid nanoparticles (SLNs). The review also discusses the advantages and disadvantages of each type of nanocarrier. Finally, we have concluded the review by emphasizing the potential of lipid-based nanocarriers to revolutionize the field of nucleic acid therapeutics, inspiring a sense of optimism and anticipation among our readers.

The most exciting aspect of this research is the potential of lipid-based nanocarriers to revolutionize the field of nucleic acid therapeutics. This potential is not just promising, but it’s a game-changer. We have highlighted the many advantages of these nanocarriers, such as their ability to protect nucleic acids from degradation, enhance their cellular uptake, and target them to specific cells and tissues. We have also discussed the recent successes of lipid-based nanocarriers in developing mRNA vaccines for COVID-19. The potential impact of this work is significant. Lipid-based nanocarriers have the potential to enable the development of new and more effective treatments for various diseases, including cancer, genetic disorders, and infectious diseases. Our review provides a valuable overview of the current state of the field. It highlights the challenges that need to be overcome to fully realize the potential of lipid-based nanocarriers.”

 

Want to know more about their work? Read the full paper here!

Graphical abstract: Recent progress on nanosystems for nucleic acid delivery

 

Recent progress on Nanosystems for Nucleic Acid Delivery

Shanka Walia and Mohit J. Mehta

RSC Pharm. 2024, Advance Article, DOI: https://doi.org/10.1039/D4PM00009A

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

 

RSC Pharmaceutics – Issue 2 now online

We are delighted to share Issue 2 of RSC Pharmaceutics. Read our new open access journal, publishing crucial research on pharmaceutics, which has the potential to drive real change in worldwide health.

“RSC Pharmaceutics will provide a platform for researchers to showcase their best work in this field and contribute to the advancement of Pharmaceutics. I look forward to promoting this journal and its published research to the community.”

Yvonne Perrie, Editor-in-Chief, RSC Pharmaceutics

Our second issue includes:

Enhancement of drug permeation across skin through stratum corneum ablation

Ayyah Abdoh, David Liu and Yousuf Mohammed

RSC Pharm., 2024,1, 151-160

DOI: 10.1039/D4PM00089G

Polymer–drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer’s disease

Nuruddin Mahadik, Gemma A. Barron, Paul Kong Thoo Lin and Colin J. Thompson

RSC Pharm., 2024,1, 161-181

DOI: 10.1039/D3PM00075C

Advances of cassava starch-based composites in novel and conventional drug delivery systems: a state-of-the-art review

Sanjoy Das, Malay K. Das, Taison Jamatia, Bireswar Bhattacharya, Rishav Mazumder, Pradip Kumar Yadav, Nayan Ranjan Ghose Bishwas, Trinayan Deka, Dhritiman Roy, Bibek Sinha, Biplajit Das, Ichu Daule, Kishan Paul, Ankita Roy, Ankita Choudhury, Pinkan Sadhukhan, Dibyojyoti Sarmah, Dhritiman Bhargab, Bani Kumar Jana, Dubom Tayeng, Nilayan Guha, Bhrigumani Kalita and Subhajit Mandal

RSC Pharm., 2024,1, 182-203

DOI: 10.1039/D3PM00008G

Potential of ultrasonic processing in biomedical applications 

Siddhi Lokhande, Bhagyashree V. Salvi and Pravin Shende

RSC Pharm., 2024,1, 204-217

DOI: 10.1039/D4PM00010B

Synthetic mucus barrier arrays as a nanoparticle formulation screening platform 

Harry Zou, Allison Boboltz, Yahya Cheema, Daniel Song, Devorah Cahn and Gregg A. Duncan

RSC Pharm., 2024,1, 218-226

DOI: 10.1039/D3PM00057E

In vitro evaluation of microneedle strength: a comparison of test configurations and experimental insights 

Bilal Harieth Alrimawi, Jing Yi Lee, Keng Wooi Ng and Choon Fu Goh

RSC Pharm., 2024,1, 227-233

DOI: 10.1039/D4PM00024B

A model binary system for the evaluation of novel ion pair formulations of diclofenac 

Mignon Cristofoli, Jonathan Hadgraft, Majella E. Lane and Bruno C. Sil

RSC Pharm., 2024,1, 234-244

DOI: 10.1039/D4PM00063C

Green synthesis of silver nanoparticles using Phyllanthus emblica extract: investigation of antibacterial activity and biocompatibility in vivo

Md Monir Hossain, Amir Hamza, Shakil Ahmed Polash, Mehedi Hasan Tushar, Masato Takikawa, Anuj Bhowmik Piash, Chaitali Dekiwadia, Tanushree Saha, Shinji Takeoka and Satya Ranjan Sarker

RSC Pharm., 2024,1, 245-258

DOI: 10.1039/D3PM00077J

Novel alginate nanoparticles for the simultaneous delivery of iron and folate: a potential nano-drug delivery system for anaemic patients 

Weranga Rajapaksha, Irosha H. W. Nicholas, T. Thoradeniya, D. Nedra Karunaratne and V. Karunaratne

RSC Pharm., 2024,1, 259-271

DOI: 10.1039/D3PM00068K

Insight into the liposomal encapsulation of mono and bis-naphthalimides

Abdullahi Magaji Dauda, Thomas Swift, Richard Telford, Hend A. A. Abd El-wahab, Chhanda Charan Danta, Klaus Pors and Amalia Ruiz

RSC Pharm., 2024,1, 272-282

DOI: 10.1039/D3PM00060E

Synthesis and biological evaluation of novel hybrid compounds bearing pyrazine and 1,2,4-triazole analogues as potent antitubercular agents

Shivakumar Naik, Dinesha Puttachari, Vanishree A. L., Udayakumar D., Varsha Prakash Shetty, Chaitra Prabhu and Vijaya Kumar Deekshit

RSC Pharm., 2024,1, 283-295

DOI: 10.1039/D3PM00054K

Thermodynamic and spectroscopic evaluation of the eutectic mixture of myristic acid and the local anaesthetics, bupivacaine and ropivacaine

Priyanka Agarwal, Darren Svirskis and Michél K. Nieuwoudt

RSC Pharm., 2024,1, 296-304

DOI: 10.1039/D3PM00082F

Development of polyethyleneimine cross-linked fucoidan nanoparticles as delivery systems for improved anticancer efficiency of cytarabine in breast adenocarcinoma cell lines

Deepa Geethakumari, Santhini Pulikkal Veettil, Sivakumar Krishnankutty Nair Chandrika, Anoop Bhaskaran Sathyabhama, Rojin Joseph, Shibin Sobhanam Padmini, Jisha V. Somasekharan and Sajeevan Thavarool Puthiyedathu

RSC Pharm., 2024,1, 305-316

DOI: 10.1039/D3PM00078H

Biocompatible, injectable and self-healable MOF-based anti-freezing eutectogels for higher encapsulation and sustained release of the anticancer drug curcumin

Nildhara Parsana,a Hiral Ukani, Dharmveer Singh Chauhan, Omar El Seoud, Sanjay Mehra, Arvind Kumar, Naina Raje and Naved Malek

RSC Pharm., 2024,1, 317-332

DOI: 10.1039/D3PM00088E

Elucidation of processing parameters for the reverse engineering of tablets 

Devendra Choudhary, Dnyaneshwar Kalyane, Suryanarayana Polaka, Tanisha Gupta and Rakesh Kumar Tekade

RSC Pharm., 2024,1, 333-343

DOI: 10.1039/D3PM00058C

Evaluation of the anti-depressant potential of EGCG-loaded nanoparticles in unstressed and stressed mice

Shakti Dahiya, Ruma Rani, Neeraj Dilbaghi, Dinesh Dhingra, Sant Lal and Jaya Verma

RSC Pharm., 2024,1, 344-356

DOI: 10.1039/D3PM00022B

Novel pH-sensitive gum ghatti-cl-poly(acrylic acid) composite hydrogel based on graphene oxide for metformin hydrochloride and sodium diclofenac combined drug-delivery systems

Pragnesh N. Dave and Pradip M. Macwan

RSC Pharm., 2024,1, 357-371

DOI: 10.1039/D3PM00072A

Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins

Hendra Saputra, Muhammad Safaat, Kazuki Uchida, Pugoh Santoso, Rie Wakabayashi, Masahiro Goto, Toki Taira and Noriho Kamiya

RSC Pharm., 2024,1, 372-378

DOI: 10.1039/D3PM00087G

These articles and our future publications are free to access by anyone.

Start reading now

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.

Sign up for email alerts and submit your manuscript.

Hear from our authors: Scott Mitchell

RSC Pharmaceutics has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

 

In this edition, we hear from Scott Mitchell about their study titled Acid- and base-resistant antimicrobial hydrogels based on polyoxometalates and chitosan.

 

“Only a few decades ago, antimicrobial resistance (AMR) was largely confined to hospitals and long-term care facilities, but over the last decade it has emerged as a serious global threat to public health. Furthermore, invasive fungal infections kill more than 1.7 million and affect over a billion people each year; however, their devastating impact on human health is not yet widely appreciated and is frequently neglected by public health authorities. In our group, we’ve used the naturally occurring polymer chitosan (CS) in combination with molecular polyoxometalates (POMs) to produce hybrid micro- and nano-capsules. Our hypothesis was that such nanostructured hybrid hydrogel materials could possess surface-active biocidal activity through additive and synergic effects. A series of pH resistance assays concluded that macroscopic hybrid hydrogels made from POMs and chitosan maintained their structural integrity after prolonged contact with both acidic and basic pH and that their potent surface-active antibiofilm properties against model bacterial strains (Gram-positive Bacillus subtilis and Gram-negative Escherichia coli) and airborne environmental moulds (Aspergillus niger and Cladosporium cladosporioides). Furthermore, the antimicrobial activity of the hydrogels could be enhanced through the inclusion of naturally occurring antimicrobial agents such as eugenol and cinnamaldehyde into the polymeric matrix.”

 

“Although we anticipated some form of antifungal activity, we didn’t anticipate these hybrid POM@CS hydrogels to perform so well in these preliminary tests against moulds. So, modulating this synergistic activity and improving the specificity towards certain strains is something that we’re really excited about.”

 

“The most challenging aspect was probably related to the transfer of synthetic procedures used to make the materials from one researcher to another. The project was initiated by Isabel Franco (a doctoral researcher) and Andrés Seral (a postdoctoral researcher), both of whom found positions in industry and academia after their contracts ended. This meant they had to transfer the synthetic protocols to Callum McWilliams (an Erasmus student from University of Glasgow) who completed the work during his research project in Zaragoza. Although it wasn’t an ideal scenario, we now know that the synthetic protocols are highly reproducible from one person to another and that’s definitely a positive outcome.”

 

“Ultimately, we hope that such synergic approaches could help to prevent the appearance of resistances. These hydrogels could easily be employed in health settings, as wound healing patches or poultices. However, there are many other instances where microbial colonization must be treated or avoided and where the appearance of resistances is troubling, e.g., biofilm build-up and blockages in water purification systems or microbiologically-influenced corrosion of engineered structures.”

 

Want to know more about their work? Read the full paper here!

Acid- and base-resistant antimicrobial hydrogels based on polyoxometalates and chitosan

Callum McWilliams, Isabel Franco-Castillo, Andrés Seral Ascaso, Sonia García-Embid, Mariella Malefioudaki, Johann G. Meier, Rafael Martín-Rapún and Scott G. Mitchell

RSC Pharm. 2024, Advance Article, DOI: 10.1039/D4PM00062E

 

RSC Pharmaceutics provides researchers with a platform to publish research in pharmaceutics and advance this field. We are interested in any submission that shares new scientific findings across chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery.