We are delighted to announce our newest themed issue on Covalent Drug Design, which is Guest Edited by Dr. Lyn Jones (Dana-Faber Cancer Institute), Prof. Keriann Backus (UCLA), and Prof. Zhengying Pan (Peking University).
This issue on covalent drug design will include areas such as covalent fragment-based drug discovery, reversible covalent warhead design, structure-based drug design and covalent docking and covalent chemical probes, natural products and degraders. For more information about the scope of this issue, or if you would like to contribute an article to this collection, please contact the Editorial Office at medchem-rsc@rsc.org.
Submissions are open from now until 3 June 2021
New research in RSC Medicinal Chemistry is published as Research Articles. This article type encompasses both Communication and Full Paper styles with no strict page limit.
All manuscripts will be subject to the journal’s usual peer review process. Accepted manuscripts will be highlighted together in a dedicated virtual issue alongside an editorial by our guest editors, regardless of submission date, and there will be no delay in the publication of all accepted manuscripts into regular issues of RSC Medicinal Chemistry.
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MedChemComm is delighted to announce a high-profile themed issue on Phenotypic Drug Discovery,due for publication online in mid-2016. The issue is being Guest Edited by Dr Fabien Vincent (Pfizer), Dr Jonathan A. Lee (Eli Lilly) and Professor Michael Pollastri (Northeastern University).
Deadline for Submission: February 1, 2016
The level of quality of this issue will be high, and all manuscripts will subject to the journal’s normal standards and peer review process. Guidelines are available at rsc.li/1K0EgYx and rsc.li/1JAwCbA
If you are interested in taking part in this issue, please email MedChemComm: medchemcomm-rsc@rsc.org
Scope of the issue
Phenotypic approaches are highly complementary to the molecular target centric strategy that prevails in Pharma and moreover, may mitigate future clinical failure issues related to target validation and lack of efficacy. Five years into the Phenotypic Drug Discovery (PDD) Renaissance, this issue aims to shift the main focus in this area from assays and screens towards the medicinal chemistry programs engendered by these early efforts. Manuscripts covering the lessons learned and progress recorded on the road to clinical candidates in the areas highlighted below are actively sought:
Design of compound libraries for phenotypic screening (e.g. biologically annotated, diversity-based and natural products libraries)
Identification of novel targets for disease-relevant phenotypes
Identification of novel chemical matter or molecular mechanisms of action for known molecular targets
Identification of novel cellular roles for known targets
Challenges in PDD hit triage such as compound/series prioritization and validation
Challenges in driving an SAR using complex assay systems (in vitro and in vivo systems)
Safety derisking and compound/project progression in the absence of a known target
Chemical biology approaches for mechanism and target deconvolution
New research in MedChemComm is published as Concise Articles. This article type encompasses both Communication and Full Paper styles with no strict page limit. There is also the opportunity to write a Review article for the issue, and if you would be interested in this please let us know.
MedChemComm is the Royal Society of Chemistry journal covering all areas of medicinal chemistry research, including research that interfaces with other areas of the chemical sciences, biology, materials science or physics
The journal is in partnership with the European Federation for Medicinal Chemistry (EFMC), and the co-Editors-in-Chief are Dr. Tony Wood (Pfizer) and Professor Greg Verdine (Harvard University). To view recent articles or to find out more about the journal please visit the website at www.rsc.org/medchemcomm
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MedChemComm is delighted to announce a high-profile themed issue on Membrane Transporters, focussing on solute carriers (SLCs). The Guest Editors for this issue are Professor Matthias A. Hediger (University of Bern, Switzerland) and Dr David Hepworth (Pfizer, Cambridge, USA).
Manuscripts can be submitted using the Royal Society of Chemistry’s online article submission service. Please clearly state that the manuscript is submitted for the themed issue on Membrane Transporters: Solute Carriers.
The level of quality of this issue will be high, and all manuscripts will undergo the journal’s normal peer review process.
Scope
Metabolic homeostasis within cells requires strict control over the import and export of metabolites, nutrients and ions across membranes. Polar chemical species such as these have negligible ability to cross phospholipid membranes by simple diffusion and instead require highly regulated transport proteins to control their movement. The largest class of transport proteins is the solute carrier series (www.bioparadigms.org) and it is on this superfamily that this special issue of MedChemComm will focus.
These proteins are of great interest for basic academic research, but beyond that they are of central importance in a number of areas of applied science: as drug targets, as controllers of drug disposition and pharmacokinetics, and as the cause of drug toxicity.
Known SLC drug targets include:
The monoamine transporter family which contains the serotonin transporter (SLC6A4) target of the highly important SSRI drug class
SLC5A2 (SGLT2), an important new anti-diabetic target to block renal glucose reabsorption
Sodium chloride transporters (SLC12 family) – the targets of loop and thiazide diuretics
SLCs important in drug pharmacokinetics and disposition include
The OATP (SLCO) and OAT (SLC22) family of anion transport
The OCT (SLC22) family of cation transport
The SLC47 multidrug and toxin extrusion family
SLCs important in drug toxicity include the thiamine transporter SLC19A2
All areas of research where the chemical sciences have impacted the study of the SLC superfamily will be considered for inclusion in this themed issue. Examples include, but are not limited to:
Medicinal chemistry and molecular probe design against these target families
Chemical biology approaches to allow for detailed study of these protein classes including physiological roles, disease mechanisms, etc.
Structural biology and biophysics of integral membrane proteins as relevant to ligand design and/or chemical biology
Molecular modelling that has enabled drug and probe design
The impact of transporters on drug disposition and pharmacokinetics – with a particular interest in structure activity relationships for such transport
The study of toxins and venoms which act through these target classes
Novel screening methodologies that allow the identification of new inhibitors, modulators and substrates of this protein class
The application of new cell biology techniques such as gene-editing, silencing and haploid genetic approaches that allow the study of chemical agents acting via these target families
Systems biology approaches to the study of chemical modulators and substrates of membrane transport proteins
The issue will consist of a series of research articles and reviews from prominent scientists who are committed to applying excellence in ion channels and membrane transporter research toward the treatment of human diseases, combining breakthroughs in both basic science and applied science, such as drug discovery.
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We are delighted to share with you a collection of research papers, review articles and books on the topic of antimicrobial resistance (AMR). Warnings about the threat of antibiotic resistance, and more broadly AMR, to human health, global food production and economic prosperity are receiving increased media interest. By 2050, it is estimated that without coordinated action, 10 million people could die from previously curable illnesses.
“At the end of this month, the World Health Organisation (WHO) will present their draft global action plan on AMR at the 68th World Health Assembly in Geneva, it is timely to consider the importance of chemistry in tackling antimicrobial resistance,” comments Professor Sylvie Garneau-Tsodikova, Editorial Board member of MedChemComm “This collection showcases the essential contributions of chemical science to understanding antibiotic resistance, developing new treatments, diagnostics and mitigations strategies to tackle this global threat.”
“The chemical sciences play a pivotal role in a sustainable and prosperous future” says Dominic Tildesley, President of the Royal Society of Chemistry “whether it’s developing new antibiotics to combat infection, converting waste to energy, or developing efficient solar energy cells, chemists are designing and applying tomorrow’s technologies”.
All articles are freely available until 18th June. All books included here have their first chapter free to read.
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Why is it important to address AMR?
Thomas Fleming outlines the role of chemistry in tackling antibiotic resistance as part of our recent chemistry in health video competition
Beating the Superbugs – avoiding an antibiotic apocalypse – a public panel discussion chaired by Michael Moseley, science journalist and TV presenter, with scientists and policy makers to discuss the challenges and possible solutions to addressing AMR.
Antibiotics from myxobacteria
Till F. Schäberle, Friederike Lohr, Alexander Schmitz and Gabriele M. König Nat. Prod. Rep., DOI: 10.1039/C4NP00011K, Review Article
AApeptides as a new class of antimicrobial agents
Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao and Jianfeng Cai Org. Biomol. Chem., DOI: 10.1039/C3OB40444G, Perspective
Inhibitors of bacterial tubulin target bacterial membranes in vivo
Marie H. Foss, Ye-Jin Eun, Charles I. Grove, Daniel A. Pauw, Nohemy A. Sorto, Jarred W. Rensvold, David J. Pagliarini, Jared T. Shaw and Douglas B. Weibel Med. Chem. Commun., DOI: 10.1039/C2MD20127E, Concise Article
We are pleased to announce an upcoming MedChemComm themed issue on Antibiotic Resistance. The Guest Editors for this issue are Professor Sylvie Garneau-Tsodikova (University of Kentucky, USA) and Professor Gerry Wright (McMaster University, Canada).
The scope of this issue is broad and encompasses, the mechanism of antibiotic resistance; discovery and development of novel antimicrobial agents; novel combination therapy; mechanism of action of novel antibiotics, and any other methods towards gaining a better understanding as well as combating bacterial infection and resistance to known antibiotics.
Manuscripts can be submitted using the Royal Society of Chemistry’s online article submission service. Please clearly state that the manuscript is submitted for the themed issue on Antibiotic Resistance.
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Guest Editors: Dr Mark Bunnage (Pfizer) and Prof. James E. Bradner (Harvard Medical School)
Submission Deadline: 16th June 2014
Submissions are now open for a high-profile themed issue on Epigenetics. The scope of the issue covers all areas of epigenetics within medicinal chemistry.
New research in MedChemComm is published as Concise Articles: flexible articles that have no strict page limits or formatting requirements. Manuscripts can be submitted in any reasonable format using our submission system. Template is not required. Please indicate that it is for the Epigenetics themed issue in the comments to the editor field. The level of quality of this issue will be high, and all manuscripts will undergo the journal’s normal peer review process.
The deadline for submissions to the themed issue is 16th June 2014, although submissions before this date are of course welcomed.
A recent workshop on the role of computer aided drug discovery was jointly held by the Royal Society of Chemistry and the Biochemical Society with the aim of aiding collaborations between biological scientists and computational chemists.
Following this workshop we have brought together a collection of articles and books that highlight recent research on computer-aided drug discovery and related areas. Below is a slection from across the Royal Society of Chemistry and you can also find a collection of articles from the Biochemical SocietyHERE…
All of the Communications, Papers and Reviews below are free to access until 7 February 2014.
Books (PDFs of the front matter, table of contents and first chapter are free to view.)
Guest Editors: Sylvie Garneau-Tsodikova (University of Kentucky, USA) and Timor Baasov (Technion-Israel Institute of Technology, Israel)
Submission Deadline: 28th February 2014
Submissions are now open for a high-profile themed issue on Carbohydrates, due for publication in MedChemComm in summer 2014. The scope of the issue covers all areas of carbohydrate chemistry and biology which are relevant to drug discovery.
New research in MedChemComm is published as Concise Articles: flexible articles that have no strict page limits or formatting requirements. Manuscripts can be submitted in any reasonable format using our submission system. Template is not required. Please indicate that it is for the Carbohydrates themed issue in the comments to the editor field. The level of quality of this issue will be high, and all manuscripts will undergo the journal’s normal peer review process.
The deadline for submissions to the themed issue is 28th February 2014, although submissions before this date are of course welcomed.
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We are pleased to present a web collection of articles from publications across the RSC journal portfolio demonstrating the use of (nano)technology in the diagnosis, imaging and treatment of cancer.
MedChemComm themed issue: Chemical Biology forTarget Identification and Validation
Guest Editors: Nathanael Gray (Harvard University, USA) and Lyn Jones (Pfizer, Cambridge, USA)
Submission Deadline: 30th September 2013
Submissions are now open for a high-profile themed issue on Chemical Biology for Target Identification and Validation, due for publication in MedChemComm in early 2014. It will receive great exposure and significant promotion.
Scope Part of MedChemComm’s mission is to publish high level chemistry biology research which enables drug discovery. This special issue will be broad in scope, covering advances in the discovery, development and application of chemical biology to elucidate and validate new therapeutic targets. Relevant topics include (but are not limited to):
the use of –omics and imaging technologies
immunoprecipitation and affinity chromatography to identify novel targets and therapeutic modalities
the creation and development of new techniques to assess target (and off-target) engagement
advances in areas such as chemogenomics, microarrays, yeast three hybrid, RNAi and chem/bioinformatics
New research in MedChemComm is published as Concise Articles. This article type encompasses both Communication and Full Paper styles and is generally between 3 and 7 pages in length, but there is no strict page limit.
Manuscripts can be submitted in any reasonable formatusing our submission system. Template is not required. Please indicate that it is for the Chemical Biology themed issue in the comments to the editor field. The level of quality of this issue will be high, and all manuscripts will undergo the journal’s normal peer review process.
The deadline for submissions to the themed issue is 30th September 2013, although submissions before this date are of course welcomed.
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Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterials
Thiazole-based aminopyrimidines and N-phenylpyrazolines as potent antimicrobial agents: synthesis and biological evaluation
Silver in Healthcare: Its Antimicrobial Efficacy and Safety in Use
Physico-Chemical and Computational Approaches to Drug Discovery
Structure-oriented bioinformatic approach exploring histidine-rich clusters in proteins