RSC Medicinal Chemistry is delighted to present our Editor’s choice collection
This collection showcases some of the best articles published in the journal, handpicked by our Associate Editors and Editorial Board members.
Below we have a selection of recent RSC Medicinal Chemistry articles chosen by Editorial Board member Dr Susanne Müller-Knapp (Goethe University Frankfurt, Germany). Take a look at which articles she chose and why.
Susanne’s favourite articles
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Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling (Open Access)
Cameron E. Taylor, Grace Roper, Rhianna Young, Fredrik Svensson, Andreas Brunschweiger, Sam Butterworth, Andrew G. Leach and Michael J. Waring* RSC Med. Chem., 2025, 16, 4774-4780 |
Susanne‘s comments:
“This article describes the details of the chemistry and enzymatic steps involved in the design and synthesis of a medium-sized DEL library using straightforward amide coupling methods.”
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Expanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation
Rebecca Stevens, Harry J. Shrives, Jenni Cryan, Diana Klimaszewska, Peter Stacey, Glenn A. Burley, John D. Harling, David J. Battersby* and Afjal H. Miah* RSC Med. Chem., 2025, 16, 1141-1150 |
Susanne‘s comments:
“Direct to biology approaches are an emerging area in the field of targeted protein degradation. In this research article, the approach has been combined with high-throughput chemistry based on key chemical reactions, namely reductive amination, SNAr, Pd-mediated cross-coupling and alkylation to accelerate generation of degrader molecules.”
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Recent advances from computer-aided drug design to artificial intelligence drug design Keran Wang, Yanwen Huang, Yan Wang*, Qidong You* and Lei Wang* RSC Med. Chem., 2024, 15, 3978-4000 |
Susanne’s comments:
“In this review article, both computer-aided drug design as well as the emerging role of evolving role of artificial intelligence in drug discovery are discussed with a focus on chemical library screening, linker generation, and de novo molecular generation.”
Meet the Editor
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Susanne Müller-Knapp, RSC Medicinal Chemistry Associate Editor
Goethe University Frankfurt, Germany Susanne Müller-Knapp is Chief Operating Officer at the Structural Genomics Consortium, SGC, Frankfurt and Director of Operations of the Chemical Probes Portal. She obtained a PhD at the Karolinska Institute in Stockholm, Sweden. After spending several years as postdoctoral researcher in the area of inflammation and gene regulation at the Karolinska Institute and at the DIBIT San Raffaele Scientific Institute in Milan, Italy, she joined 2004 the SGC, at Oxford University, where she coordinated the Epigenetic Probe Project and lead a group, focusing on the evaluation of novel chemical probes, cellular target engagement of these tool compounds and their biological roles. Her research now focuses on using chemical biology to dissect the role of specific targets in biology and disease with a main focus on cancer. In her role as Director of Operations for the Chemical Probes Portal, she focuses on providing data and knowledge on high quality chemical tools and establishing quality standards for chemical probes with diverse modes of action. |
We hope you enjoyed reading these articles. Keep an eye out on our collection webpage for more of our Editors’ favourite articles.
