RSC Medicinal Chemistry Blog

This month sees the following articles in MedChemComm that are in the top ten most accessed:

The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Thomas S. Elliott, Aine Slowey, Yulin Ye and Stuart J. Conway
Med. Chem. Commun., 2012, 3, 735-751
DOI: 10.1039/C2MD20079A

The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
Timothy J. Ritchie, Simon J. F. Macdonald, Simon Peace, Stephen D. Pickett and Christopher N. Luscombe
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20111A

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Gd(III) chelates for MRI contrast agents: from high relaxivity to “smart”, from blood pool to blood–brain barrier permeable
Chang-Tong Yang and Kai-Hsiang Chuang
Med. Chem. Commun., 2012, 3, 552-565
DOI: 10.1039/C2MD00279E

Determination of drug–receptor residence times by radioligand binding and functional assays: experimental strategies and physiological relevance
Georges Vauquelin
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20015E

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

Superiority of a novel EGFR targeted covalent inhibitor over its reversible counterpart in overcoming drug resistance
Juswinder Singh, Erica Evans, Margit Hagel, Matthew Labinski, Alex Dubrovskiy, Mariana Nacht, Russell C. Petter, Aravind Prasad, Michael Sheets, Thia St Martin, Robert Tjin Tham Sjin, William Westlin and Zhendong Zhu
Med. Chem. Commun., 2012, 3, 780-783
DOI: 10.1039/C2MD20017A

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases
Thomas Beckers, Siavosh Mahboobi, Andreas Sellmer, Matthias Winkler, Emerich Eichhorn, Herwig Pongratz, Thomas Maier, Thomas Ciossek, Thomas Baer, Gerhard Kelter, Heinz-Herbert Fiebig and Mathias Schmidt
Med. Chem. Commun., 2012, 3, 829-835
DOI: 10.1039/C2MD00317A

Oxadiazole isomers: all bioisosteres are not created equal
Kristin Goldberg, Sam Groombridge, Julian Hudson, Andrew G. Leach, Philip A. MacFaul, Adrian Pickup, Ruth Poultney, James S. Scott, Per H. Svensson and Joseph Sweeney
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20054F

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Thomas S. Elliott, Aine Slowey, Yulin Ye and Stuart J. Conway
Med. Chem. Commun., 2012, 3, 735-751
DOI: 10.1039/C2MD20079A

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Gd(III) chelates for MRI contrast agents: from high relaxivity to “smart”, from blood pool to blood–brain barrier permeable
Chang-Tong Yang and Kai-Hsiang Chuang
Med. Chem. Commun., 2012, 3, 552-565
DOI: 10.1039/C2MD00279E

Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain
Andrew G. Leach, Elizabeth A. Pilling, Alfred A. Rabow, Simone Tomasi, Nabil Asaad, Niklaas J. Buurma, Andrew Ballard and Stefania Narduolo
Med. Chem. Commun., 2012, 3, 528-540
DOI: 10.1039/C2MD20010D

Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein–protein and protein–DNA interactions
Jeremy L. Yap, Jay Chauhan, Kwan-Young Jung, Lijia Chen, Edward V. Prochownik and Steven Fletcher
Med. Chem. Commun., 2012, 3, 541-551
DOI: 10.1039/C2MD00289B

Oxadiazole isomers: all bioisosteres are not created equal
Kristin Goldberg, Sam Groombridge, Julian Hudson, Andrew G. Leach, Philip A. MacFaul, Adrian Pickup, Ruth Poultney, James S. Scott, Per H. Svensson and Joseph Sweeney
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20054F

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
Alexander Alex, David S. Millan, Manuel Perez, Florian Wakenhut and Gavin A. Whitlock
Med. Chem. Commun., 2011, 2, 669-674
DOI: 10.1039/C1MD00093D

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries
Albert A. Bowers
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20068F

Biosynthetic medicinal chemistry of natural product drugs
Frank E. Koehn
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00316C

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Oxadiazole isomers: all bioisosteres are not created equal
Kristin Goldberg, Sam Groombridge, Julian Hudson, Andrew G. Leach, Philip A. MacFaul, Adrian Pickup, Ruth Poultney, James S. Scott, Per H. Svensson and Joseph Sweeney
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20054F

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Gd(III) chelates for MRI contrast agents: from high relaxivity to “smart”, from blood pool to blood–brain barrier permeable
Chang-Tong Yang and Kai-Hsiang Chuang
Med. Chem. Commun., 2012, 3, 552-565
DOI: 10.1039/C2MD00279E

Small molecules DNA methyltransferases inhibitors
Nadine Martinet, Benoît Y. Michel, Philippe Bertrand and Rachid Benhida
Med. Chem. Commun., 2012, 3, 263-273
DOI: 10.1039/C1MD00194A

Determination of drug–receptor residence times by radioligand binding and functional assays: experimental strategies and physiological relevance
Georges Vauquelin
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20015E

Biosynthetic medicinal chemistry of natural product drugs
Frank E. Koehn
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00316C

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Discovery of novel morpholino–quinoxalines as PI3Kα inhibitors by pharmacophore-based screening
Peng Wu, Yi Su, Xiaowen Liu, Jingying Yan, Yong Ye, Lei Zhang, Jianchao Xu, Shaoyu Weng, Yani Li, Tao Liu, Xiaowu Dong, Maotang Sun, Bo Yang, Qiaojun He and Yongzhou Hu
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00255H

A solid-phase method for peptide–siRNA covalent conjugates based on click chemistry
Yang Liu, Xiao-Feng Wang, Yue Chen, Li-He Zhang and Zhen-Jun Yang
Med. Chem. Commun., 2012, 3, 506-511
DOI: 10.1039/C2MD00198E

Targeting the inactive conformation of protein kinases: computational screening based on ligand conformation
Pascal Bonnet, Daniel Mucs and Richard A. Bryce
Med. Chem. Commun., 2012, 3, 434-440
DOI: 10.1039/C1MD00256B

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Squaric acid: a valuable scaffold for developing antimalarials?
S. Praveen Kumar, Paulo M. C. Glória, Lídia M. Gonçalves, Jiri Gut, Philip J. Rosenthal, Rui Moreira and Maria M. M. Santos
Med. Chem. Commun., 2012, 3, 489-493
DOI: 10.1039/C2MD20011B

Small molecules DNA methyltransferases inhibitors
Nadine Martinet, Benoît Y. Michel, Philippe Bertrand and Rachid Benhida
Med. Chem. Commun., 2012, 3, 263-273
DOI: 10.1039/C1MD00194A

Oxadiazole isomers: all bioisosteres are not created equal
Kristin Goldberg, Sam Groombridge, Julian Hudson, Andrew G. Leach, Philip A. MacFaul, Adrian Pickup, Ruth Poultney, James S. Scott, Per H. Svensson and Joseph Sweeney
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD20054F

Development of novel ionic liquids based on ampicillin
Ricardo Ferraz, Luís C. Branco, Isabel M. Marrucho, João M. M. Araújo, Luis Paulo N. Rebelo, Manuel Nunes da Ponte, Cristina Prudêncio, João Paulo Noronha and Željko Petrovski
Med. Chem. Commun., 2012, 3, 494-497
DOI: 10.1039/C2MD00269H

A second generation MRI contrast agent for imaging zinc ions in vivo
Luis M. De León-Rodríguez, Angelo J. M. Lubag, Jorge A. López, Gabriel Andreu-de-Riquer, José C. Alvarado-Monzón and A. Dean Sherry
Med. Chem. Commun., 2012, 3, 480-483
DOI: 10.1039/C2MD00301E

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

From the protein’s perspective: the benefits and challenges of protein structure-based pharmacophore modeling
Marijn P. A. Sanders, Ross McGuire, Luc Roumen, Iwan J. P. de Esch, Jacob de Vlieg, Jan P. G. Klomp and Chris de Graaf
Med. Chem. Commun., 2012, 3, 28-38
DOI: 10.1039/C1MD00210D

Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy
Silviya D. Furdas, Luca Carlino, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2012, 3, 123-134
DOI: 10.1039/C1MD00201E

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Investigation of the effect of molecular properties on the binding kinetics of a ligand to its biological target
Duncan C. Miller, Graham Lunn, Peter Jones, Yogesh Sabnis, Nichola L. Davies and Paul Driscoll
Med. Chem. Commun., 2012, 3, 449-452
DOI: 10.1039/C2MD00270A

Epigenetics—an emerging and highly promising source of new drug targets
Nessa Carey
Med. Chem. Commun., 2012, 3, 162-166
DOI: 10.1039/C1MD00264C

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy
Silviya D. Furdas, Luca Carlino, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2012, 3, 123-134
DOI: 10.1039/C1MD00201E

Development of second generation epigenetic agents
Philip Jones
Med. Chem. Commun., 2012, 3, 135-161
DOI: 10.1039/C1MD00199J

Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases
Silviya D. Furdas, Suhaib Shekfeh, Srinivasaraghavan Kannan, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2012, 3, 305-311
DOI: 10.1039/C2MD00211F

Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein–protein and protein–DNA interactions
Jeremy L. Yap, Jay Chauhan, Kwan-Young Jung, Lijia Chen, Edward V. Prochownik and Steven Fletcher
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00289B

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

SAR mining and its application to the design of TRPA1 antagonists
James E. J. Mills, Alan D. Brown, Thomas Ryckmans, Duncan C. Miller, Sarah E. Skerratt, Carolyn M. Barker and Mark E. Bunnage
Med. Chem. Commun., 2012, 3, 174-178
DOI: 10.1039/C1MD00213A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Antimalarial peroxides: advances in drug discovery and design
Rachel D. Slack, Alexander M. Jacobine and Gary H. Posner
Med. Chem. Commun., 2012, 3, 281-297
DOI: 10.1039/C2MD00277A

Structural enrichment of HTS compounds from available commercial libraries
Tetyana Petrova, Alexander Chuprina, Raman Parkesh and Alexei Pushechnikov
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00302C

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

Polyamine-based small molecule epigenetic modulators
Shiv K. Sharma, Stuart Hazeldine, Michael L. Crowley, Allison Hanson, Ross Beattie, Sheeba Varghese, Thulani M. D. Senanayake, Aiko Hirata, Fusao Hirata, Yi Huang, Yu Wu, Nora Steinbergs, Tracey Murray-Stewart, Ian Bytheway, Robert A. Casero and Patrick M. Woster
Med. Chem. Commun., 2012, 3, 14-21
DOI: 10.1039/C1MD00220A

The discovery of novel 10,11-dihydro-5H-dibenz[b,f]azepine SIRT2 inhibitors
Paolo Di Fruscia, Ka-Kei Ho, Sasiwan Laohasinnarong, Mattaka Khongkow, Sebastian H. B. Kroll, Suhail A. Islam, Michael J. E. Sternberg, Karin Schmidtkunz, Manfred Jung, Eric W.-F. Lam and Matthew J. Fuchter
Med. Chem. Commun., 2012, 3, 373-378
DOI: 10.1039/C2MD00290F

The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc ₁ protein complex
Robin Cowley, Suet Leung, Nicholas Fisher, Mohammed Al-Helal, Neil G. Berry, Alexandre S. Lawrenson, Raman Sharma, Alison E. Shone, Stephen A. Ward,  Giancarlo A. Biagini and Paul M. O′Neill
Med. Chem. Commun., 2012, 3, 39-44
DOI: 10.1039/C1MD00183C

A comparative analysis of the molecular topologies for drugs, clinical candidates, natural products, human metabolites and general bioactive compounds
Hongming Chen,  Ola Engkvist,  Niklas Blomberg and Jin Li
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00238H

Inhibitors of Stat5 protein signalling
Abbarna A. Cumaraswamy, Aleksandra Todic, Diana Resetca, Mark D. Minden and Patrick T. Gunning
Med. Chem. Commun., 2012, 3, 22-27
DOI: 10.1039/C1MD00175B

From the protein’s perspective: the benefits and challenges of protein structure-based pharmacophore modeling
Marijn P. A. Sanders, Ross McGuire, Luc Roumen, Iwan J. P. de Esch, Jacob de Vlieg, Jan P. G. Klomp and Chris de Graaf
Med. Chem. Commun., 2012, 3, 28-38
DOI: 10.1039/C1MD00210D

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
Alexander Alex, David S. Millan, Manuel Perez, Florian Wakenhut and Gavin A. Whitlock
Med. Chem. Commun., 2011, 2, 669-674
DOI: 10.1039/C1MD00093D

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

A comparative analysis of the molecular topologies for drugs, clinical candidates, natural products, human metabolites and general bioactive compounds
Hongming Chen,  Ola Engkvist,  Niklas Blomberg and Jin Li
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00238H

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

Epigenetics — an emerging and highly promising source of new drug targets
Nessa Carey
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C1MD00264C

2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization
Ahmed Kamal, Y. V. V. Srikanth, Thokhir B. Shaik, M. Naseer A. Khan, Md. Ashraf, M. Kashi Reddy, K. Anil Kumar and Shasi V. Kalivendi
Med. Chem. Commun., 2011, 2, 819-823
DOI: 10.1039/C0MD00177E

The discovery and profile of PF-0868087, a CNS-sparing histamine H3 receptor antagonist for the treatment of allergic rhinitis
Graham Lunn, Charles E. Mowbray, Wai L. S. Liu, Valerie M. Joynson, Tanya Hay and Michael Yeadon
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00276K

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
Xinyi Song, Yuanjun He, Marcel Koenig, Youseung Shin, Romain Noel, Weimin Chen, Yuan Yuan Ling, Daniel Feurstein, Li Lin, Claudia H. Ruiz, Michael D. Cameron, Derek R. Duckett and Theodore M. Kamenecka
Med. Chem. Commun., 2012, 3, 238-243
DOI: 10.1039/C1MD00219H

Impact of ion class and time on oral drug molecular properties
Paul D. Leeson,  Stephen A. St-Gallay and Mark C. Wenlock
Med. Chem. Commun., 2011, 2, 91-105
DOI: 10.1039/C0MD00157K

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

Development of second generation epigenetic agents
Philip Jones
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C1MD00199J

Small molecules DNA methyltransferases inhibitors
Nadine Martinet, Benoît Y. Michel, Philippe Bertrand and Rachid Benhida
Med. Chem. Commun., 2011, Advance Article
DOI: 10.1039/C1MD00194A

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Epigenetics — an emerging and highly promising source of new drug targets
Nessa Carey
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C1MD00264C

Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as Plasmodium falciparum transketolase and ß-hematin inhibitors
Moni Sharma, Kuldeep Chauhan, Shikha S. Chauhan, Ashok Kumar, Shiv Vardan Singh, Jitendra K. Saxena, Pooja Agarwal, Kumkum Srivastava, S. Raja Kumar, Sunil K. Puri, Priyanka Shah, M. I. Siddiqi and Prem M. S. Chauhan
Med. Chem. Commun., 2012, 3, 71-79
DOI: 10.1039/C1MD00188D

Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones
Allimuthu T. Dharmaraja, Tapan K. Dash, V. Badireenath Konkimalla and Harinath Chakrapani
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C1MD00234A

Inhibition of bromodomain-mediated protein—protein interactions as a novel therapeutic strategy
Silviya D. Furdas, Luca Carlino, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C1MD00201E

2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization
Ahmed Kamal, Y. V. V. Srikanth, Thokhir B. Shaik, M. Naseer A. Khan, Md. Ashraf, M. Kashi Reddy, K. Anil Kumar and Shasi V. Kalivendi
Med. Chem. Commun., 2011, 2, 819-823
DOI: 10.1039/C0MD00177E

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.