RSC Medicinal Chemistry Blog

This month sees the following articles in MedChemComm that are in the top ten most accessed:-

Molecular obesity, potency and other addictions in drug discovery 
Michael M. Hann 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C1MD00017A, Review 

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry 
Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain and James E. Mills 
Med. Chem. Commun., 2010, 1, 309-318, DOI: 10.1039/C0MD00135J  

Identification of target family directed bioisosteric replacements
Anne Mai Wassermann and Jürgen Bajorath 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C1MD00066G  

The p53-MDM2/MDMX axis – A chemotype perspective 
Kareem Khoury, Grzegorz M. Popowicz, Tad A. Holak and Alexander Dömling 
Med. Chem. Commun., 2011, 2, 246-260, DOI: 10.1039/C0MD00248H, Review 

Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies 
Paras N. Yadav, Ramsay E. Beveridge, Jonathan Blay, Alaina R. Boyd, Maja W. Chojnacka, Andreas Decken, Ankur A. Deshpande, Michael G. Gardiner, Trevor W. Hambley, Michael J. Hughes, Leslie Jolly, Jacquelyn A. Lavangie, Timothy D. MacInnis, Sherri A. McFarland, Elizabeth J. New and Robert A. Gossage 
Med. Chem. Commun., 2011, 2, 274-277, DOI: 10.1039/C0MD00211A  

Natural products targeting telomere maintenance 
Jack Li-Yang Chen, Jonathan Sperry, Nancy Y. Ip and Margaret A. Brimble 
Med. Chem. Commun., 2011, 2, 229-245, DOI: 10.1039/C0MD00241K  

(Carboxydiamine)Pt(ii) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects 
Miroslava Zoldakova, Bernhard Biersack, Hana Kostrhunova, Aamir Ahmad, Subhash Padhye, Fazlul H. Sarkar, Rainer Schobert and Viktor Brabec 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C1MD00042J  

Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents 
Chebolu Naga Sesha Sai Pavan Kumar, Dusmant Kumar Parida, Amlipur Santhoshi, Anil Kumar Kota, Balasubramanian Sridhar and Vaidya Jayathirtha Rao 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00263A 

Synthesis and efficient siRNA delivery of polyamine-conjugated cationic nucleoside lipids 
Sachin Prakash Patil, Jeong Wu Yi, Eun-Kyoung Bang, Eun Mi Jeon and Byeang Hyean Kim 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C1MD00014D  

N-(5-substituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators 
Zhiqing Liu, Qingzhang Zhu, Fuying Li, Lina Zhang, Ying Leng and Ao Zhang 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C1MD00002K  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:-

Molecular obesity, potency and other addictions in drug discovery 
Michael M. Hann 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C1MD00017A, Review 

Synthesis and SAR studies of benzimidazole derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Focus to detune hERG inhibition 
Pradip K. Sasmal, Sanjita Sasmal, Chandrasekhar Abbineni, B. Venkatesham, P. Tirumala Rao, M. Roshaiah, Ish Khanna, V. J. Sebastian, J. Suresh, Manvendra P. Singh, Rashmi Talwar, Dhanya Shashikumar, K. Harinder Reddy, Thomas M. Frimurer, Øystein Rist, Lisbeth Elster and Thomas Högberg 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C1MD00015B, Concise Article 

Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure-activity relationship 
Shoujun Chen, Zhiqiang Xia, Masazumi Nagai, Rongzhen Lu, Elena Kostik, Teresa Przewloka, Minghu Song, Dinesh Chimmanamada, David James, Shijie Zhang, Jun Jiang, Mitsunori Ono, Keizo Koya and Lijun Sun 
Med. Chem. Commun., 2011, 2, 176-180 DOI: 10.1039/C0MD00215A, Concise Article 

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection 
David C. Pryde, Thien-Duc Tran, Peter Jones, Gemma C. Parsons, Gerwyn Bish, Fiona M. Adam, Mya C. Smith, Donald S. Middleton, Nick N. Smith, Frederick Calo, Duncan Hay, Michael Paradowski, Katie J. W. Proctor, Tanya Parkinson, Carl Laxton, David N. A. Fox, Nigel J. Horscroft, Giuseppe Ciaramella, Hannah M. Jones, Jonathan Duckworth, Neil Benson, Anthony Harrison and Rob Webster 
Med. Chem. Commun., 2011, 2, 185-189 DOI: 10.1039/C0MD00197J, Concise Article 

Discovery and pharmacological characterization of a selective delta opiate receptor antagonist (CP-646,777) 
Spiros Liras, Stanton F. McHardy, Martin P. Allen, Barb E. Segelstein, Steven D. Heck, Dianne K. Bryce, Anne W. Schmidt, Rebecca O’Connor, Michelle Vanase-Frawley, Ernesto Callegari and Stafford McLean 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C0MD00249F, Concise Article 

The importance of solvation in the design of ligands targeting membrane proteins 
Angel González, Marta Murcia, Bellinda Benhamú, Mercedes Campillo, María L. López-Rodríguez and Leonardo Pardo 
Med. Chem. Commun., 2011, 2, 160-164 DOI: 10.1039/C0MD00258E, Concise Article 

The p53-MDM2/MDMX axis – A chemotype perspective 
Kareem Khoury, Grzegorz M. Popowicz, Tad A. Holak and Alexander Dömling 
Med. Chem. Commun., 2011, 2, 246-260 DOI: 10.1039/C0MD00248H, Review 

Chemical space as a source for new drugs 
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit 
Med. Chem. Commun., 2010, 1, 30-38 DOI: 10.1039/C0MD00020E, Review 

Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase 
Joshua J. Bornstein, Todd J. Eckroat, Jacob L. Houghton, Christopher K. Jones, Keith D. Green and Sylvie Garneau-Tsodikova 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C0MD00256A, Concise Article 

Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD+-dependent DNA ligase inhibitors 
Rama P. Tripathi, Jyoti Pandey, Vandana Kukshal, Arya Ajay, Mridul Mishra, Divya Dube, Deepti Chopra, R. Dwivedi, Vinita Chaturvedi and Ravishankar Ramachandran 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C0MD00246A, Concise Article 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:- 

Impact of ion class and time on oral drug molecular properties 
Paul D. Leeson, Stephen A. St-Gallay and Mark C. Wenlock 
Med. Chem. Commun., 2011, 2, 91-105, DOI: 10.1039/C0MD00157K, Review 

The importance of solvation in the design of ligands targeting membrane proteins 
Angel González, Marta Murcia, Bellinda Benhamú, Mercedes Campillo, María L. López-Rodríguez and Leonardo Pardo 
Med. Chem. Commun., 2011, 2, 160-164, DOI: 10.1039/C0MD00258E, Concise Article 

Chemical space as a source for new drugs 
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit 
Med. Chem. Commun., 2010, 1, 30-38, DOI: 10.1039/C0MD00020E, Review 

Novel, unifying mechanism for aromatic primary-amines (therapeutics, carcinogens and toxins): electron transfer, reactive oxygen species, oxidative stress and metabolites 
Peter Kovacic and Ratnasamy Somanathan 
Med. Chem. Commun., 2011, 2, 106-112, DOI: 10.1039/C0MD00233J, Review 

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications 
Paul C. Trippier and Christopher McGuigan 
Med. Chem. Commun., 2010, 1, 183-198, DOI: 10.1039/C0MD00119H, Review 

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection 
David C. Pryde, Thien-Duc Tran, Peter Jones, Gemma C. Parsons, Gerwyn Bish, Fiona M. Adam, Mya C. Smith, Donald S. Middleton, Nick N. Smith, Frederick Calo, Duncan Hay, Michael Paradowski, Katie J. W. Proctor, Tanya Parkinson, Carl Laxton, David N. A. Fox, Nigel J. Horscroft, Giuseppe Ciaramella, Hannah M. Jones, Jonathan Duckworth, Neil Benson, Anthony Harrison and Rob Webster 
Med. Chem. Commun., 2011, 2, 185-189, DOI: 10.1039/C0MD00197J, Concise Article 

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model 
Juyoun Jin, Woo Sirl Lee, Kyeung Min Joo, Kaustabh K. Maiti, Goutam Biswas, Wanil Kim, Kyong-Tai Kim, Se Jeong Lee, Kang-Ho Kim, Do-Hyun Nam and Sung-Kee Chung 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00235F, Concise Article 

Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold 
Guyan Liang, Kent Neuenschwander, Xin Chen, Linli Wei, Randall Munson, Gerardo Francisco, Anthony Scotese, Gregory Shutske, Mark Black, Sharkir Sarhan, Jason Jiang, Isabelle Morize and Roy J. Vaz 
Med. Chem. Commun., 2011, 2, 201-205, DOI: 10.1039/C0MD00255K, Concise Article 

Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction 
Timothy E. Allsopp, Mark E. Bunnage and Paul V. Fish 
Med. Chem. Commun., 2010, 1, 16-29, DOI: 10.1039/C0MD00055H, Review 

Conformational effects on potency of thioimidazoles and dihydrothiazolines 
Roland Selig, Verena Schattel, Marcia Goettert, Dieter Schollmeyer, Wolfgang Albrecht and Stefan Laufer 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00228C, Concise Article 

Why not take a look at the articles today and blog your thoughts and comments below. Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:-

Silver nanoparticles – the real “silver bullet” in clinical medicine? 
Kenneth K. Y. Wong and Xuelai Liu 
Med. Chem. Commun., 2010, 1, 125-131, DOI: 10.1039/C0MD00069H, Review 

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases
Elisabeth-Maria Bissinger, Ralf Heinke, Wolfgang Sippl and Manfred Jung  
Med. Chem. Commun., 2010, 1, 114-124, DOI: 10.1039/C0MD00062K, Review 

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design 
Hengmiao Cheng, Shubha Bagrodia, Simon Bailey, Martin Edwards, Jacqui Hoffman, Qiyue Hu, Robert Kania, Daniel R. Knighton, Matthew A. Marx, Sacha Ninkovic, Shaoxian Sun and Eric Zhang 
Med. Chem. Commun., 2010, 1, 139-144 , DOI: 10.1039/C0MD00072H, Concise Article 

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications 
Paul C. Trippier and Christopher McGuigan 
Med. Chem. Commun., 2010, 1, 183-198, DOI: 10.1039/C0MD00119H, Review 

Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction 
Timothy E. Allsopp, Mark E. Bunnage and Paul V. Fish 
Med. Chem. Commun., 2010, 1, 16-29, DOI: 10.1039/C0MD00055H, Review 

Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives 
Anusch Arezki, Guy G. Chabot, Lionel Quentin, Daniel Scherman, Gérard Jaouen and Emilie Brulé 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00231C, Concise Article 

Chemical space as a source for new drugs 
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit 
Med. Chem. Commun., 2010, 1, 30-38, DOI: 10.1039/C0MD00020E, Review 

Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure-activity relationship 
Shoujun Chen, Zhiqiang Xia, Masazumi Nagai, Rongzhen Lu, Elena Kostik, Teresa Przewloka, Minghu Song, Dinesh Chimmanamada, David James, Shijie Zhang, Jun Jiang, Mitsunori Ono, Keizo Koya and Lijun Sun 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00215A, Concise Article 

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry 
Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain and James E. Mills 
Med. Chem. Commun., 2010, 1, 309-318, DOI: 10.1039/C0MD00135J, Review 

Biofunctional TiO2 nanoparticle-mediated photokilling of cancer cells using UV irradiation 
Kazusa Matsui, Miki Karasaki, Maiko Segawa, Sang Youn Hwang, Tsutomu Tanaka, Chiaki Ogino and Akihiko Kondo 
Med. Chem. Commun., 2010, 1, 209-211, DOI: 10.1039/C0MD00027B, Concise Article 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in MedChemComm that are in the top ten most accessed:-

Silver nanoparticles – the real “silver bullet” in clinical medicine? 
Kenneth K. Y. Wong and Xuelai Liu 
Med. Chem. Commun., 2010, 1, 125-131, DOI: 10.1039/C0MD00069H, Review 

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications 
Paul C. Trippier and Christopher McGuigan 
Med. Chem. Commun., 2010, 1, 183-198, DOI: 10.1039/C0MD00119H, Review 

Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction 
Timothy E. Allsopp, Mark E. Bunnage and Paul V. Fish 
Med. Chem. Commun., 2010, 1, 16-29, DOI: 10.1039/C0MD00055H, Review 

Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists 
Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Morag Ferguson, Richard Goodwin, Fiona Jeremiah, Takao Kiyoi, Ashvin Mistry, Elizabeth Moir, Richard Morphy, Jason Tierney, Mark York, James Baker, Jean E. Cottney, Andrea K. Houghton, Paul J. Westwood and Glenn Walker 
Med. Chem. Commun., 2010, 1, 54-60, DOI: 10.1039/C0MD00022A, Concise Article 

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry 
Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain and James E. Mills 
Med. Chem. Commun., 2010, 1, 309-318, DOI: 10.1039/C0MD00135J, Review 

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases
Elisabeth-Maria Bissinger, Ralf Heinke, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2010, 1, 114-124, DOI: 10.1039/C0MD00062K, Review 

Chemical space as a source for new drugs 
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit 
Med. Chem. Commun., 2010, 1, 30-38, DOI: 10.1039/C0MD00020E, Review 

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design 
Hengmiao Cheng, Shubha Bagrodia, Simon Bailey, Martin Edwards, Jacqui Hoffman, Qiyue Hu, Robert Kania, Daniel R. Knighton, Matthew A. Marx, Sacha Ninkovic, Shaoxian Sun and Eric Zhang 
Med. Chem. Commun., 2010, 1, 139-144, DOI: 10.1039/C0MD00072H, Concise Article 

Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors 
Yen Ting Chen, Tomas Vojkovsky, Xingang Fang, Jennifer R. Pocas, Wayne Grant, Amiee M. W. Handy, Thomas Schröter, Philip LoGrasso, Thomas D. Bannister and Yangbo Feng 
Med. Chem. Commun., 2011, 2, 73-75, DOI: 10.1039/C0MD00194E, Concise Article 

Design, synthesis and biological evaluation of imidazopyridine/pyrimidine-chalcone derivatives as potential anticancer agents 
Ahmed Kamal, J. Surendranadha Reddy, M. Janaki Ramaiah, D. Dastagiri, E. Vijaya Bharathi, M. Victor Prem Sagar, S. N. C. V. L. Pushpavalli, Paramita Ray and Manika Pal-Bhadra 
Med. Chem. Commun., 2010, 1, 355-360, DOI: 10.1039/C0MD00116C, Concise Article 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.