RSC Medicinal Chemistry Blog

Please take a look at the following articles which were the Top Ten most accessed during January, February and March!

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton  
Med. Chem. Commun., 2011,2, 1135-1161
DOI: 10.1039/c1md00134e

Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain
Alicia Merlino, Diego Benitez, Nuria E. Campillo, Juan A. Páez, Luzineide W. Tinoco, Mercedes González and Hugo Cerecetto  
Med. Chem. Commun., 2012,3, 90-101
DOI: 10.1039/c1md00223f

Discovery of BET bromodomain inhibitors and their role in target validation
S. Müller and S. Knapp
Med. Chem. Commun., 2014,5, 288-296
DOI: 10.1039/c3md00291h

Metabolism-guided drug design
Antonia F. Stepan, Vincent Mascitti, Kevin Beaumont and Amit S. Kalgutkar
Med. Chem. Commun., 2013,4, 631-652
DOI: 10.1039/c2md20317k

3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF from Lysobacter enzymogenes C3
Yaoyao Li, Justin Huffman, Yu Li, Liangcheng Du and Yuemao Shen
Med. Chem. Commun., 2012,3, 982-986
DOI: 10.1039/c2md20026k

Affinity-based target identification for bioactive small molecules
Makoto Kawatani and Hiroyuki Osada
Med. Chem. Commun., 2014,5, 277-287
DOI: 10.1039/c3md00276d

Fragment growing to retain or alter the selectivity of anchored kinase hinge-binding fragments
Charlotte E. Allen, Amanda J. Welford, Thomas P. Matthews, John J. Caldwell and Ian Collins  
Med. Chem. Commun., 2014,5, 180-185
DOI: 10.1039/c3md00308f

Ambient mass spectrometry technologies for the detection of falsified drugs
María J. Culzoni, Prabha Dwivedi, Michael D. Green, Paul N. Newton and Facundo M. Fernández  
Med. Chem. Commun., 2014,5, 9-19
DOI: 10.1039/c3md00235g

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry
Davide Garella, Emily Borretto, Antonella Di Stilo, Katia Martina, Giancarlo Cravotto and Pedro Cintas  
Med. Chem. Commun., 2013,4, 1323-1343
DOI: 10.1039/c3md00152k

Target validation using in-cell small molecule clickable imaging probes
Brahma Ghosh and Lyn H. Jones
Med. Chem. Commun., 2014,5, 247-254
DOI: 10.1039/c3md00277b

If you have any thoughts or comments on any of these articles, please leave these in the comment box below!

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During October, November and December, the following articles were the Top Ten most accessed:

Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of disease-causing nonsense mutations
Jeyakumar Kandasamy, Dana Atia-Glikin, Valery Belakhov and Timor Baasov
Med. Chem. Commun., 2011,2, 165-171
DOI: 10.1039/c0md00195c

Recent applications of multicomponent reactions in medicinal chemistry
Paul Slobbe, Eelco Ruijter and Romano V. A. Orru
Med. Chem. Commun., 2012,3, 1189-1218
DOI: 10.1039/c2md20089a

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011,2, 1135-1161
DOI: 10.1039/c1md00134e

Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments
James R. Hitchin, Julian Blagg, Rosemary Burke, Samantha Burns, Mark J. Cockerill, Emma E. Fairweather, Colin Hutton, Allan M. Jordan, Craig McAndrew, Amin Mirza, Daniel Mould, Graeme J. Thomson, Ian Waddell and Donald J. Ogilvie
Med. Chem. Commun., 2013,4, 1513-1522
DOI: 10.1039/c3md00226h

Design, synthesis and antiproliferative activity of indole analogues of indanocine
Gemma A. Tunbridge, Joseph Oram and Lorenzo Caggiano
Med. Chem. Commun., 2013,4, 1452-1456
DOI: 10.1039/c3md00200d

Gd(iii) chelates for MRI contrast agents: from high relaxivity to “smart”, from blood pool to blood–brain barrier permeable
Chang-Tong Yang and Kai-Hsiang Chuang
Med. Chem. Commun., 2012,3, 552-565
DOI: 10.1039/c2md00279e

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry
Davide Garella, Emily Borretto, Antonella Di Stilo, Katia Martina, Giancarlo Cravotto and Pedro Cintas
Med. Chem. Commun., 2013,4, 1323-1343
DOI: 10.1039/c3md00152k

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions
Tim J. Blackburn, Shafiq Ahmed, Christopher R. Coxon, Junfeng Liu, Xiaohong Lu, Bernard T. Golding, Roger J. Griffin, Claire Hutton, David R. Newell, Stephen Ojo, Anna F. Watson, Andrey Zaytzev, Yan Zhao, John Lunec and Ian R. Hardcastle
Med. Chem. Commun., 2013,4, 1297-1304
DOI: 10.1039/c3md00161j

Metabolism-guided drug design
Antonia F. Stepan, Vincent Mascitti, Kevin Beaumont and Amit S. Kalgutkar
Med. Chem. Commun., 2013,4, 631-652
DOI: 10.1039/c2md20317k

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines
Alexander Ciupa, Paul A. De Bank, Mary F. Mahon, Pauline J. Wood and Lorenzo Caggiano
Med. Chem. Commun., 2013,4, 956-961
DOI: 10.1039/c3md00077j

Do you have any comments or thoughts on any of these articles? Please leave these in the comment box below!

If you would like to submit an article to MedChemComm, please visit our submission site!

Please take a look at the top 10 most accessed articles MedChemComm articles for July, August and September. 

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011,2, 1135-1161
DOI: 10.1039/c1md00134e 

A critical assessment of modeling safety-related drug attrition
Daniel Muthas, Scott Boyer and Catrin Hasselgren
Med. Chem. Commun., 2013,4, 1058-1065
DOI: 10.1039/c3md00072a 

Metabolism-guided drug design
Antonia F. Stepan, Vincent Mascitti, Kevin Beaumont and Amit S. Kalgutkar
Med. Chem. Commun., 2013,4, 631-652
DOI: 10.1039/c2md20317k 

Silver nanoparticles—the real “silver bullet” in clinical medicine?
Kenneth K. Y. Wong and Xuelai Liu
Med. Chem. Commun., 2010,1, 125-131
DOI: 10.1039/c0md00069h 

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions
Tim J. Blackburn, Shafiq Ahmed, Christopher R. Coxon, Junfeng Liu, Xiaohong Lu, Bernard T. Golding, Roger J. Griffin, Claire Hutton, David R. Newell, Stephen Ojo, Anna F. Watson, Andrey Zaytzev, Yan Zhao, John Lunec and Ian R. Hardcastle   Med. Chem. Commun., 2013,4, 1297-1304
DOI: 10.1039/C3MD00161J 

Highlights from ASMC’13 – Advances in Synthetic and Medicinal Chemistry – May 5–8 2013, Moscow, Russia
Edmond Differding
Med. Chem. Commun., 2013,4, 1138-1144
DOI: 10.1039/c3md90017g 

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry
Davide Garella, Emily Borretto, Antonella Di Stilo, Katia Martina, Giancarlo Cravotto and Pedro Cintas  
Med. Chem. Commun., 2013,4, 1323-1343
DOI: 10.1039/C3MD00152K 

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines
Alexander Ciupa, Paul A. De Bank, Mary F. Mahon, Pauline J. Wood and Lorenzo Caggiano  
Med. Chem. Commun., 2013,4, 956-961
DOI: 10.1039/C3MD00077J 

Peptides: minimal drug surrogates to interrogate and interfere with protein function
A. Cruz-Migoni, N. Fuentes-Fernandez and T. H. Rabbitts
Med. Chem. Commun., 2013,4, 1218-1221
DOI: 10.1039/c3md00142c  

Chemical motifs that redox cycle and their associated toxicity
Payal Rana, Russell Naven, Arjun Narayanan, Yvonne Will and Lyn H. Jones
Med. Chem. Commun., 2013,4, 1175-1180
DOI: 10.1039/c3md00149k 

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If you have an article that you would like to submit to MedChemComm, please submit to us here!