Reuben J. Peters (Iowa State University) and Francis Mann (Winona Sate University) provide a short and topical account of the discovery of the isotuberculosinol diterpenoid prodution by bacteria Mycobacterium tuberculosis (Mtb).
The authors review the recent findings showing evidence of the biological role of this diterpenoid in the infection process of Mtb. Based on genetic and genomic analysis, the authors also provide insight into the origin of the tuberculosinol gene cluster and its role in human infection.
Curious? Why not read the review article now and let us know what you think…
Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis
Francis M. Mann and Reuben J. Peters
DOI: 10.1039/C2MD20030A
This review is part of MedChemComm’s Natural Products themed issue, guest-edited by Prof. Christopher Walsh and Dr Sylvie Garneau-Tsodikova.
