The articles below are some of the most read MedChemComm articles in January, February and March 2016. 
Multivalent glycoconjugates as vaccines and potential drug candidates
Sumati Bhatia, Mathias Dimde and Rainer Haag
DOI: 10.1039/C4MD00143E, Review Article
Thermoresponsive fluorinated small-molecule drugs: a new concept for efficient localized chemotherapy
Catherine M. Clavel, Patrycja Nowak-Sliwinska, Emilia Păunescu and Paul J. Dyson
DOI: 10.1039/C5MD00409H, Review Article
Mechanisms of resistance to membrane-disrupting antibiotics in Gram-positive and Gram-negative bacteria
Kfir B. Steinbuch and Micha Fridman
DOI: 10.1039/C5MD00389J, Review Article
Endless resistance. Endless antibiotics?
Jed F. Fisher and Shahriar Mobashery
DOI: 10.1039/C5MD00394F, Review Article
Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects
Isidro Cortés-Ciriano, Qurrat Ul Ain, Vigneshwari Subramanian, Eelke B. Lenselink, Oscar Méndez-Lucio, Adriaan P. IJzerman, Gerd Wohlfahrt, Peteris Prusis, Thérèse E. Malliavin, Gerard J. P. van Westen and Andreas Bender
DOI: 10.1039/C4MD00216D, Review Article
Surface plasmon resonance for the characterization of bacterial polysaccharide antigens: a review
Barbara Brogioni and Francesco Berti
DOI: 10.1039/C4MD00088A, Review Article
Towards understanding cell penetration by stapled peptides
Qian Chu, Raymond E. Moellering, Gerard J. Hilinski, Young-Woo Kim, Tom N. Grossmann, Johannes T.-H. Yeh and Gregory L. Verdine
DOI: 10.1039/C4MD00131A, Concise Article
Rational design of protein–protein interaction inhibitors
Didier Rognan
DOI: 10.1039/C4MD00328D, Review Article
Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
Caroline Haglund, Chitralekha Mohanty, Mårten Fryknäs, Padraig D’Arcy, Rolf Larsson, Stig Linder and Linda Rickardson
DOI: 10.1039/C3MD00386H, Concise Article
Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives
Sylvie Garneau-Tsodikova and Kristin J. Labby
DOI: 10.1039/C5MD00344J, Review Article
Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor
Enade P. Istyastono, Albert J. Kooistra, Henry F. Vischer, Martien Kuijer, Luc Roumen, Saskia Nijmeijer, Rogier A. Smits, Iwan J. P. de Esch, Rob Leurs and Chris de Graaf
DOI: 10.1039/C5MD00022J, Concise Article
6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents
Pavla Perlíková, Petr Konečný, Petr Nauš, Jan Snášel, Ivan Votruba, Petr Džubák, Iva Pichová, Marián Hajdúch and Michal Hocek
DOI: 10.1039/C3MD00232B, Concise Article
2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography
Torsten Kniess, Markus Laube, Peter Brust and Jörg Steinbach
DOI: 10.1039/C5MD00303B, Review Article
Targeting the trehalose utilization pathways of Mycobacterium tuberculosis
Sandeep Thanna and Steven J. Sucheck
DOI: 10.1039/C5MD00376H, Review Article
Synergistic activity of a short lipidated antimicrobial peptide (lipoAMP) and colistin or tobramycin against Pseudomonas aeruginosa from cystic fibrosis patients
Martin G. de Gier, H. Bauke Albada, Michaele Josten, Rob Willems, Helen Leavis, Rosa van Mansveld, Fernanda L. Paganelli, Bertie Dekker, Jan-Willem J. Lammers, Hans-Georg Sahl and Nils Metzler-Nolte
DOI: 10.1039/C5MD00373C, Concise Article
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership
John Mann, Peter W. Taylor, Colin R. Dorgan, Peter D. Johnson, Francis X. Wilson, Richard Vickers, Aaron G Dale and Stephen Neidle
DOI: 10.1039/C5MD00238A, Review Article
Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains
Duncan A. Hay, Catherine M. Rogers, Oleg Fedorov, Cynthia Tallant, Sarah Martin, Octovia P. Monteiro, Susanne Müller, Stefan Knapp, Christopher J. Schofield and Paul E. Brennan
DOI: 10.1039/C5MD00152H, Concise Article
Molecular basis for resistance against phosphonate antibiotics and herbicides
Jonathan R. Chekan, Dillon P. Cogan and Satish K. Nair
DOI: 10.1039/C5MD00351B, Review Article
Structural biology and chemistry of protein arginine methyltransferases
Matthieu Schapira and Renato Ferreira de Freitas
DOI: 10.1039/C4MD00269E, Review Article
A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides
Nishad Thamban Chandrika and Sylvie Garneau-Tsodikova
DOI: 10.1039/C5MD00453E, Review Article
Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance
Kathryn M. Hart, Margaret Reck, Gregory R. Bowman and Timothy A. Wencewicz
DOI: 10.1039/C5MD00325C, Concise Article
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