The articles below are some of the most read MedChemComm articles in January, February and March 2016. 
Multivalent glycoconjugates as vaccines and potential drug candidates
Sumati Bhatia, Mathias Dimde and Rainer Haag
DOI: 10.1039/C4MD00143E, Review Article
Thermoresponsive fluorinated small-molecule drugs: a new concept for efficient localized chemotherapy
Catherine M. Clavel, Patrycja Nowak-Sliwinska, Emilia Păunescu and Paul J. Dyson
DOI: 10.1039/C5MD00409H, Review Article
Mechanisms of resistance to membrane-disrupting antibiotics in Gram-positive and Gram-negative bacteria
Kfir B. Steinbuch and Micha Fridman
DOI: 10.1039/C5MD00389J, Review Article
Endless resistance. Endless antibiotics?
Jed F. Fisher and Shahriar Mobashery
DOI: 10.1039/C5MD00394F, Review Article
Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects
Isidro Cortés-Ciriano, Qurrat Ul Ain, Vigneshwari Subramanian, Eelke B. Lenselink, Oscar Méndez-Lucio, Adriaan P. IJzerman, Gerd Wohlfahrt, Peteris Prusis, Thérèse E. Malliavin, Gerard J. P. van Westen and Andreas Bender
DOI: 10.1039/C4MD00216D, Review Article
Surface plasmon resonance for the characterization of bacterial polysaccharide antigens: a review
Barbara Brogioni and Francesco Berti
DOI: 10.1039/C4MD00088A, Review Article
Towards understanding cell penetration by stapled peptides
Qian Chu, Raymond E. Moellering, Gerard J. Hilinski, Young-Woo Kim, Tom N. Grossmann, Johannes T.-H. Yeh and Gregory L. Verdine
DOI: 10.1039/C4MD00131A, Concise Article
Rational design of protein–protein interaction inhibitors
Didier Rognan
DOI: 10.1039/C4MD00328D, Review Article
Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
Caroline Haglund, Chitralekha Mohanty, Mårten Fryknäs, Padraig D’Arcy, Rolf Larsson, Stig Linder and Linda Rickardson
DOI: 10.1039/C3MD00386H, Concise Article
Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives
Sylvie Garneau-Tsodikova and Kristin J. Labby
DOI: 10.1039/C5MD00344J, Review Article
