The articles below are the most read MedChemComm articles in July, August and September 2015.
Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)
G. W. Karpin, D. M. Morris, M. T. Ngo, J. S. Merola and J. O. Falkinham III
DOI: 10.1039/C5MD00228A, Concise Article
Multivalent glycoconjugates as vaccines and potential drug candidates
Sumati Bhatia, Mathias Dimde and Rainer Haag
DOI: 10.1039/C4MD00143E, Review Article
Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects
Isidro Cortés-Ciriano, Qurrat Ul Ain, Vigneshwari Subramanian, Eelke B. Lenselink, Oscar Méndez-Lucio, Adriaan P. IJzerman, Gerd Wohlfahrt, Peteris Prusis, Thérèse E. Malliavin, Gerard J. P. van Westen and Andreas Bender
DOI: 10.1039/C4MD00216D, Review Article
Towards understanding cell penetration by stapled peptides
Qian Chu, Raymond E. Moellering, Gerard J. Hilinski, Young-Woo Kim, Tom N. Grossmann, Johannes T.-H. Yeh and Gregory L. Verdine
DOI: 10.1039/C4MD00131A, Concise Article
Rational design of protein–protein interaction inhibitors
Didier Rognan
DOI: 10.1039/C4MD00328D, Review Article
Magic molecule modifiers
Derek Lowe
DOI: 10.1039/C5MD90028J, In the Pipeline
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor
Katherine S. England, Anthony Tumber, Tobias Krojer, Giuseppe Scozzafava, Stanley S. Ng, Michelle Daniel, Aleksandra Szykowska, KaHing Che, Frank von Delft, Nicola A. Burgess-Brown, Akane Kawamura, Christopher J. Schofield and Paul E. Brennan
DOI: 10.1039/C4MD00291A, Concise Article
Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
Caroline Haglund, Chitralekha Mohanty, Mårten Fryknäs, Padraig D’Arcy, Rolf Larsson, Stig Linder and Linda Rickardson
DOI: 10.1039/C3MD00386H, Concise Article
Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics
Malinda Salim, Hiroyuki Minamikawa, Akihiko Sugimura and Rauzah Hashim
DOI: 10.1039/C4MD00085D, Review Article
Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains
Duncan A. Hay, Catherine M. Rogers, Oleg Fedorov, Cynthia Tallant, Sarah Martin, Octovia P. Monteiro, Susanne Müller, Stefan Knapp, Christopher J. Schofield and Paul E. Brennan
DOI: 10.1039/C5MD00152H, Concise Article
Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril
Xiaoqing Miao, Ye Li, Ian Wyman, Simon M. Y. Lee, Donal H. Macartney, Ying Zheng and Ruibing Wang
DOI: 10.1039/C5MD00189G, Concise Article
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership
John Mann, Peter W. Taylor, Colin R. Dorgan, Peter D. Johnson, Francis X. Wilson, Richard Vickers, Aaron G Dale and Stephen Neidle
DOI: 10.1039/C5MD00238A, Review Article
3-Aminooxazolidinone AHL analogs as hydrolytically-stable quorum sensingagonists in Gram-negative bacteria
Min Guo, Yue Zheng, Rusty Starks, Clement Opoku-Temeng, Xiaochu Ma and Herman O. Sintim
DOI: 10.1039/C5MD00015G, Concise Article
Surface plasmon resonance for the characterization of bacterial polysaccharide antigens: a review
Barbara Brogioni and Francesco Berti
DOI: 10.1039/C4MD00088A, Review Article
Affinity-based target identification for bioactive small molecules
Makoto Kawatani and Hiroyuki Osada
DOI: 10.1039/C3MD00276D, Review Article
Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)
S. D. Furdas, I. Hoffmann, D. Robaa, B. Herquel, W. Malinka, P. Świątek, A. Akhtar, W. Sippl and M. Jung
DOI: 10.1039/C4MD00245H, Concise Article
Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides
Martin Klečka, Lenka Poštová Slavětínská, Eva Tloušťová, Petr Džubák, Marián Hajdúch and Michal Hocek
DOI: 10.1039/C4MD00492B, Concise Article
A fundamental view of enthalpy–entropy compensation
Ulf Ryde
DOI: 10.1039/C4MD00057A, Concise Article
Antisense oligonucleotides: modifications and clinical trials
Vivek K. Sharma, Raman K. Sharma and Sunil K. Singh
DOI: 10.1039/C4MD00184B, Review Article
Recent applications of multicomponent reactions in medicinal chemistry
Paul Slobbe, Eelco Ruijter and Romano V. A. Orru
DOI: 10.1039/C2MD20089A, Review Article
Silver nanoparticles—the real “silver bullet” in clinical medicine?
Kenneth K. Y. Wong and Xuelai Liu
DOI: 10.1039/C0MD00069H, Review Article
Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases
Ronald W. Brown and Christopher J. T. Hyland
DOI: 10.1039/C5MD00174A, Review Article
