In this commentary article, Mark Bunnage and colleagues propose that by developing a ‘chemical probe tool kit’, chemical biology can play a more important part in seeking out potentially relevant targets.
Target validation using chemical probes
Mark E Bunnage, Eugene L Piatnitski Chekler & Lyn H Jones
Nature Chemical Biology, 9, 195–199 (2013)
Editors’ Choice articles are articles identified as being of high potential interest to medicinal chemists, selected from the wider literature by members of the Editorial Board.