Multicomponent reactions (MCRs) are defined as being a one-pot process that involves the reaction of at least three components to form a single product that retains the majority of the atoms from the starting materials.
These reactions are atom economic, step efficient, and owing to their flexibility, have found applications in many fields of medicinal chemistry, such as cancer therapy and infectious diseases, where MCRs are powerful tools for drug discovery and development. The application in these fields is quite broad, ranging from initial lead structure identification to the generation of large libraries of analogues.
In this Review Romano V. A. Orru and colleagues from VU University Amsterdam highlight recent applications (2005-present) of multicomponent reactions in medicinal chemistry, discussing these applications by therapeutic field.
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Recent applications of multicomponent reactions in medicinal chemistry
Paul Slobbe, Eelco Ruijter and Romano V. A. Orru