Top ten most accessed articles in December

This month sees the following articles in MedChemComm that are in the top ten most accessed:

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
Alexander Alex, David S. Millan, Manuel Perez, Florian Wakenhut and Gavin A. Whitlock
Med. Chem. Commun., 2011, 2, 669-674
DOI: 10.1039/C1MD00093D

Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

A comparative analysis of the molecular topologies for drugs, clinical candidates, natural products, human metabolites and general bioactive compounds
Hongming Chen,  Ola Engkvist,  Niklas Blomberg and Jin Li
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00238H

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011, 2, 1033-1049
DOI: 10.1039/C1MD00158B

Epigenetics — an emerging and highly promising source of new drug targets
Nessa Carey
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C1MD00264C

2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization
Ahmed Kamal, Y. V. V. Srikanth, Thokhir B. Shaik, M. Naseer A. Khan, Md. Ashraf, M. Kashi Reddy, K. Anil Kumar and Shasi V. Kalivendi
Med. Chem. Commun., 2011, 2, 819-823
DOI: 10.1039/C0MD00177E

The discovery and profile of PF-0868087, a CNS-sparing histamine H3 receptor antagonist for the treatment of allergic rhinitis
Graham Lunn, Charles E. Mowbray, Wai L. S. Liu, Valerie M. Joynson, Tanya Hay and Michael Yeadon
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00276K

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
Xinyi Song, Yuanjun He, Marcel Koenig, Youseung Shin, Romain Noel, Weimin Chen, Yuan Yuan Ling, Daniel Feurstein, Li Lin, Claudia H. Ruiz, Michael D. Cameron, Derek R. Duckett and Theodore M. Kamenecka
Med. Chem. Commun., 2012, 3, 238-243
DOI: 10.1039/C1MD00219H

Impact of ion class and time on oral drug molecular properties
Paul D. Leeson,  Stephen A. St-Gallay and Mark C. Wenlock
Med. Chem. Commun., 2011, 2, 91-105
DOI: 10.1039/C0MD00157K

Why not take a look at the articles today and blog your thoughts and comments below.

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