In this MedChemComm review Matthew Duncton, Renovis Inc., highlights the attractive potential of Minisci reactions – addition of radicals to heteroaromatic bases – for medicinal and biological chemists.
These reactions can be used to introduce a broad-range of selective CH-functionalization groups, such as alkyls, cycloalkyls, sugars, esters and more. In many cases, these processes are highly chemo- and regio-selective, making them ideal for industrial applications, because complicating factors such as protecting group strategies can be avoided.
Read this review now for specific examples and future developments of these useful reactions. It’s free to download for the next 4 weeks!
Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton, Med. Chem. Commun., 2011, DOI: 10.1039/C1MD00134E
