This month sees the following articles in MedChemComm that are in the top ten most accessed:
Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
Alexander Alex, David S. Millan, Manuel Perez, Florian Wakenhut and Gavin A. Whitlock
Med. Chem. Commun., 2011, 2, 669-674
DOI: 10.1039/C1MD00093D
Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
Med. Chem. Commun., 2011, 2, 349-355
DOI: 10.1039/C1MD00017A
Are pyridazines privileged structures?
Camille G. Wermuth
Med. Chem. Commun., 2011, Advance Article
DOI: 10.1039/C1MD00074H
Identification of target family directed bioisosteric replacements
Anne Mai Wassermann and Jürgen Bajorath
Med. Chem. Commun., 2011, 2, 601-606
DOI: 10.1039/C1MD00066G
Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents
Chebolu Naga Sesha Sai Pavan Kumar, Dusmant Kumar Parida, Amlipur Santhoshi, Anil Kumar Kota, Balasubramanian Sridhar and Vaidya Jayathirtha Rao
Med. Chem. Commun., 2011, 2, 486-492
DOI: 10.1039/C0MD00263A
Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4)
Antonio Macchiarulo, Nicola Giacchè, Andrea Carotti, Fabiola Moretti and Roberto Pellicciari
Med. Chem. Commun., 2011, 2, 455-465
DOI: 10.1039/C0MD00238K
Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications
Paul C. Trippier and Christopher McGuigan
Med. Chem. Commun., 2010, 1, 193-198
DOI: 10.1039/C0MD00119H
Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry
Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain and James E. Mills
Med. Chem. Commun., 2010, 1, 309-318
DOI: 10.1039/C0MD00135J
Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1
Shashwat Malhotra, Sakshi Balwani, Ashish Dhawan, Brajendra K. Singh, Sarvesh Kumar, Rajesh Thimmulappa, Shyam Biswal, Carl E. Olsen, Erik Van der Eycken, Ashok K. Prasad, Balaram Ghosh and Virinder S. Parmar
Med. Chem. Commun., 2011, 2, 743-751
DOI: 10.1039/C0MD00262C
Overcoming retinoic acid receptor-a based testicular toxicity in the optimisation of glucokinase activators
Michael J. Waring, Iain J. Brogan, Matthew Coghlan, Craig Johnstone, Huw B. Jones, Brendan Leighton, Darren McKerrecher, Kurt G. Pike and Graeme R. Robb
Med. Chem. Commun., 2011, 2, 771-774
DOI: 10.1039/C1MD00090J
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