Camille Wermuth, Prestwick Chemical Inc., France, presents an interesting account of the use, and potential, of pyridazine scaffolds in medicinal chemistry in this hot review. He suggests that the pyridazine scaffold is a privileged structure, i.e. it is capable of providing useful ligands for more than one receptor, and has several advantages over the commonly used phenyl ring.
This article is part of the collection: 21st International Symposium on Medicinal Chemistry (EFMC-ISMC 2010) and is free to access:
Are pyridazines privileged structures?
Camille G. Wermuth
Med. Chem. Commun., 2011, Advance Article
DOI: 10.1039/C1MD00074H
