Top ten most accessed articles in February

This month sees the following articles in MedChemComm that are in the top ten most accessed:- 

Impact of ion class and time on oral drug molecular properties 
Paul D. Leeson, Stephen A. St-Gallay and Mark C. Wenlock 
Med. Chem. Commun., 2011, 2, 91-105, DOI: 10.1039/C0MD00157K, Review 

The importance of solvation in the design of ligands targeting membrane proteins 
Angel González, Marta Murcia, Bellinda Benhamú, Mercedes Campillo, María L. López-Rodríguez and Leonardo Pardo 
Med. Chem. Commun., 2011, 2, 160-164, DOI: 10.1039/C0MD00258E, Concise Article 

Chemical space as a source for new drugs 
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit 
Med. Chem. Commun., 2010, 1, 30-38, DOI: 10.1039/C0MD00020E, Review 

Novel, unifying mechanism for aromatic primary-amines (therapeutics, carcinogens and toxins): electron transfer, reactive oxygen species, oxidative stress and metabolites 
Peter Kovacic and Ratnasamy Somanathan 
Med. Chem. Commun., 2011, 2, 106-112, DOI: 10.1039/C0MD00233J, Review 

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications 
Paul C. Trippier and Christopher McGuigan 
Med. Chem. Commun., 2010, 1, 183-198, DOI: 10.1039/C0MD00119H, Review 

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection 
David C. Pryde, Thien-Duc Tran, Peter Jones, Gemma C. Parsons, Gerwyn Bish, Fiona M. Adam, Mya C. Smith, Donald S. Middleton, Nick N. Smith, Frederick Calo, Duncan Hay, Michael Paradowski, Katie J. W. Proctor, Tanya Parkinson, Carl Laxton, David N. A. Fox, Nigel J. Horscroft, Giuseppe Ciaramella, Hannah M. Jones, Jonathan Duckworth, Neil Benson, Anthony Harrison and Rob Webster 
Med. Chem. Commun., 2011, 2, 185-189, DOI: 10.1039/C0MD00197J, Concise Article 

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model 
Juyoun Jin, Woo Sirl Lee, Kyeung Min Joo, Kaustabh K. Maiti, Goutam Biswas, Wanil Kim, Kyong-Tai Kim, Se Jeong Lee, Kang-Ho Kim, Do-Hyun Nam and Sung-Kee Chung 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00235F, Concise Article 

Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold 
Guyan Liang, Kent Neuenschwander, Xin Chen, Linli Wei, Randall Munson, Gerardo Francisco, Anthony Scotese, Gregory Shutske, Mark Black, Sharkir Sarhan, Jason Jiang, Isabelle Morize and Roy J. Vaz 
Med. Chem. Commun., 2011, 2, 201-205, DOI: 10.1039/C0MD00255K, Concise Article 

Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction 
Timothy E. Allsopp, Mark E. Bunnage and Paul V. Fish 
Med. Chem. Commun., 2010, 1, 16-29, DOI: 10.1039/C0MD00055H, Review 

Conformational effects on potency of thioimidazoles and dihydrothiazolines 
Roland Selig, Verena Schattel, Marcia Goettert, Dieter Schollmeyer, Wolfgang Albrecht and Stefan Laufer 
Med. Chem. Commun., 2011, Advance Article, DOI: 10.1039/C0MD00228C, Concise Article 

Why not take a look at the articles today and blog your thoughts and comments below. Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

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