December 2010 – RSC Medicinal Chemistry Blog

Archive for December, 2010

MedChemComm is now indexed in ISI

22 Dec 2010

We are really pleased to say that MedChemComm is now being indexed in ISI Web of Science.

Issue 1 is already there and some of the articles have already been cited. Congratulations to Jean-Louis Reymond, Julia M. Adam, Franco Chimenti and Zhisong Lu and their research teams for being the first cited authors of MedChemComm in ISI.

Remember that you can now read all these articles for free!

Happy Holidays and best wishes for 2011!

Chemical space as a source for new drugs
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit
Med. Chem. Commun., 2010, 1, 30-38
DOI: 10.1039/C0MD00020E

Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Morag Ferguson, Richard Goodwin, Fiona Jeremiah, Takao Kiyoi, Ashvin Mistry, Elizabeth Moir, Richard Morphy, Jason Tierney, Mark York, James Baker, Jean E. Cottney, Andrea K. Houghton, Paul J. Westwood and Glenn Walker
Med. Chem. Commun., 2010, 1, 54-60
DOI: 10.1039/C0MD00022A

Synthesis and selective inhibition of human monoamine oxidasesof a large scaffold of (4,5-substituted-thiazol-2-yl)hydrazones
Franco Chimenti, Daniela Secci, Adriana Bolasco, Paola Chimenti, Arianna Granese, Simone Carradori, Melissa D’Ascenzio, Matilde Yáñez and Francisco Orallo
Med. Chem. Commun., 2010, 1, 61-72
DOI: 10.1039/C0MD00014K

Effect of particle shape on phagocytosisof CdTe quantum dot–cystinecomposites
Zhisong Lu, Yan Qiao, Xin Ting Zheng, Mary B. Chan-Park and Chang Ming Li
Med. Chem. Commun., 2010, 1, 84-86
DOI: 10.1039/C0MD00008F

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Hybrid ligands targeting Aβ fibrillization for Alzheimer

17 Dec 2010

Alzheimer disease is the most common form of dementia. It is a neurodegenerative disorder characterized by a progression from episodic memory problems to a slow global decline of cognitive function and it affects 10% of the people over the age of 65.

Unfortunately, the current treatments are purely symptom-relieving and an actual treatment or prevention of Alzheimer is still lacking.

Ilona B. Bruinsma and her team at Nijmegen, The Netherlands, have designed bifunctional “β -sheet breakers” that interfere with the portions of the Aβ peptide known to contribute to aggregation and GAG interaction.

Read this interesting paper free to access from MedChemComm

A rational design to create hybrid β-sheet breaker peptides to inhibit aggregation and toxicity of amyloid-β
Ilona B. Bruinsma, Anna Karawajczyk, Gijs Schaftenaar, Robert M. W. de Waal, Marcel M. Verbeek and Floris L. van Delft
Med. Chem. Commun., 2011, Advance Article
DOI: 10.1039/C0MD00213E

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MedChemComm Symposium a great success!

07 Dec 2010

The MedChemComm UK-China Symposium took place last month. The Symposium, organised by MedChemComm and the RSC International Programme, took place on the 22nd November at the Chemistry Centre in London.

Professor Zhenjun Yang presenting at the symposium

A great line-up of speakers gave presentations on topics from across the broad spectrum of medicinal chemistry. Dr Jason Wong (Roche R&D Centre, China) started off the day with his work on the development of a novel epigenetic modulator for hepatocellular carcinoma. Jason was followed by MedChemComm Editorial Board member Dr Mark Bunnage (Pfizer, UK), who talked about small molecule modulators of stem cells, and then Professor Zhenjun Yang (Peking University, China) reporting chemically modified siRNAs and their biological properties.

Dr Rich Soll (WuXi AppTec, China) opened up after lunch describing collaborative medicinal chemistry at WuXi AppTec, followed by Professor Paul Wyatt (University of Dundee, UK) describing some of his recent work developing antiparasitic leads. Rounding off the day were Professor Fa-Jun Nan (Shanghai Institute of Materia Medica, CAS, China), speaking about a hepatitis B inhibitor derived from a marine natural product, and Professor Chris Abell (University of Cambridge, UK), who spoke about anti-tuberculosis natural products.

Dr Richard Pike, CEO of the Royal Society of Chemistry and Professor Jingkang Shen, representing the Chinese Pharmaceutical Association, exchange gifts

Many thanks to the organising committee, the symposium sponsors – Pfizer and AstraZeneca – and everyone who attended.

Why not contribute to the success of MedChemComm by submitting your article today?

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Top ten most accessed articles in October

06 Dec 2010

This month sees the following articles in MedChemComm that are in the top ten most accessed:-

Silver nanoparticles – the real “silver bullet” in clinical medicine?
Kenneth K. Y. Wong and Xuelai Liu
Med. Chem. Commun., 2010, 1, 125-131, DOI: 10.1039/C0MD00069H, Review

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases
Elisabeth-Maria Bissinger, Ralf Heinke, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2010, 1, 114-124, DOI: 10.1039/C0MD00062K, Review

Chemical space as a source for new drugs
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit
Med. Chem. Commun., 2010, 1, 30-38, DOI: 10.1039/C0MD00020E, Review

Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction
Timothy E. Allsopp, Mark E. Bunnage and Paul V. Fish
Med. Chem. Commun., 2010, 1, 16-29, DOI: 10.1039/C0MD00055H, Review

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications
Paul C. Trippier and Christopher McGuigan
Med. Chem. Commun., 2010, 1, 183-198, DOI: 10.1039/C0MD00119H, Review

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design
Hengmiao Cheng, Shubha Bagrodia, Simon Bailey, Martin Edwards, Jacqui Hoffman, Qiyue Hu, Robert Kania, Daniel R. Knighton, Matthew A. Marx, Sacha Ninkovic, Shaoxian Sun and Eric Zhang
Med. Chem. Commun., 2010, 1, 139-144, DOI: 10.1039/C0MD00072H, Concise Article

Data-mining patent literature for novel chemical reagents for use in medicinal chemistry design
Jason G. Kettle, Richard A. Ward and Ed Griffen
Med. Chem. Commun., 2010, 1, 331-338, DOI: 10.1039/C0MD00148A, Concise Article

Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Morag Ferguson, Richard Goodwin, Fiona Jeremiah, Takao Kiyoi, Ashvin Mistry, Elizabeth Moir, Richard Morphy, Jason Tierney, Mark York, James Baker, Jean E. Cottney, Andrea K. Houghton, Paul J. Westwood and Glenn Walker
Med. Chem. Commun., 2010, 1, 54-60, DOI: 10.1039/C0MD00022A, Concise Article

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry
Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain and James E. Mills
Med. Chem. Commun., 2010, 1, 309-318, DOI: 10.1039/C0MD00135J, Review

Selective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolines
Hiroyuki Nakamura, Ryoji Horikoshi, Taikou Usui and Hyun Seung Ban
Med. Chem. Commun., 2010, 1, 282-286, DOI: 10.1039/C0MD00115E, Concise Article

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to MedChemComm? Then why not submit to us today or alternatively email us your suggestions.

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HOT: Estrogen dependent breast cancer lead compound

02 Dec 2010

Adam McCluskey and colleagues at The University of Newcastle have developed a library of compounds that can act as anti-cancer agents.

In this paper, they report the discovery of a family of 2-phenylacrylonitriles with excellent growth inhibition of a panel of ten human cancer cell lines.

Read this MedChemComm full paper free to access.

Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound
Mark Tarleton, Jayne Gilbert, Mark J. Robertson, Adam McCluskey and Jennette A. Sakoff
Med. Chem. Commun., 2011, Advance Article
DOI: 10.1039/C0MD00147C , Concise Article

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RSC Medicinal Chemistry Blog

Archive for December, 2010

MedChemComm is now indexed in ISI

Hybrid ligands targeting Aβ fibrillization for Alzheimer

MedChemComm Symposium a great success!

Top ten most accessed articles in October

HOT: Estrogen dependent breast cancer lead compound

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