Archive for the ‘News’ Category

Point of Care Diagnostics Workshop – 4 Dec 2012, London UK

Point-of-Care Diagnostics Workshop
4 December 2012, Burlington House, London, UK

Point-of-care diagnostic (POC) test devices provide rapid results on an ever expanding range of medical tests, helping to streamline healthcare and improve clinical outcomes. Research on microfluidics for POC applications has increased markedly in recent years, fuelled by an interest in constructing field-deployable analytical instruments. The interest in POC microfluidic-based devices has been intense and has cut across all major disciplines in lab-on-a-chip research, including engineering (biomedical, chemical, electrical, and mechanical), chemistry, and physics.  For further details please visit the website.

Abstract submission deadline: 31 October 2012. Abstract submission is now available online.

Application deadline: 31 October 2012. Application is now available online.

Workshop format
The aims of this Joint Biochemical Society/Royal Society of Chemistry workshop are to provide participants with a better understanding of the challenges involved in translating research outputs into application and to help encourage collaborations with industry and clinicians on POC. The workshop will bring together researchers who work at the interface between biology, chemistry and the wider life and medical sciences. Participants will be encouraged to participate in oral presentations, as well as in discussion groups intended to help move this area forward.

Speakers
Dr Ana Alfirevic, University of Liverpool, UK
Professor Andrew de Mello, ETH Zürich, Switzerland

Attendance is by application only and will be FREE of charge for Biochemical Society and Royal Society of Chemistry members.

This workshop is the fourth of a series entitled “Analytical Tools for the Life Sciences”, a collaborative project between the Biochemical Society and Royal Society of Chemistry members.

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Want to know more about Organs-on-chips? Read our free articles!

As the meeting at the Lorentz Center entitled ‘Organs on Chips: Human Disease Models‘ draws to a close, we thought we’d remind you about the fantastic free* collection of articles we’ve put together from Lab on a Chip and Integrative Biology on the topic.

The collection can be found here, and includes papers such as:

Microengineered physiological biomimicry: Organs-on-Chips
Dongeun Huh, Yu-suke Torisawa, Geraldine A. Hamilton, Hyun Jung Kim and Donald E. Ingber
DOI: 10.1039/C2LC40089H

Organs-on-chips: breaking the in vitro impasse
Andries D. van der Meer and Albert van den Berg
DOI: 10.1039/C2IB00176D

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
Anna Grosberg, Patrick W. Alford, Megan L. McCain and Kevin Kit Parker
DOI: 10.1039/C1LC20557A

Hurry though, as the collection is only available with free* access till the 8th October!

*Free access is provided to recognised institutions or to individuals through an RSC Publishing Personal Account. Registration is quick and easy at http://pubs.rsc.org/en/account/register.

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Top ten most accessed articles in July 2012

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:

Microfluidically-unified cell culture, sample preparation, imaging and flow cytometry for measurement of cell signaling pathways with single cell resolution
Meiye Wu, Thomas D. Perroud, Nimisha Srivastava, Catherine S. Branda, Kenneth L. Sale, Bryan D. Carson, Kamlesh D. Patel, Steven S. Branda and Anup K. Singh
Lab Chip, 2012, 12, 2823-2831
DOI: 10.1039/C2LC40344G

Blood separation on microfluidic paper-based analytical devices
Temsiri Songjaroen, Wijitar Dungchai, Orawon Chailapakul, Charles S. Henry and Wanida Laiwattanapaisal
Lab Chip, 2012, 12, 3392-3398
DOI: 10.1039/C2LC21299D

Microfluidic electronics
Shi Cheng and Zhigang Wu
Lab Chip, 2012, 12, 2782-2791
DOI: 10.1039/C2LC21176A

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices
Ju Hun Yeon, Hyun Ryul Ryu, Minhwan Chung, Qing Ping Hu and Noo Li Jeon
Lab Chip, 2012, 12, 2815-2822
DOI: 10.1039/C2LC40131B

High throughput method for prototyping three-dimensional, paper-based microfluidic devices
Gregory G. Lewis, Matthew J. DiTucci, Matthew S. Baker and Scott T. Phillips
Lab Chip, 2012, 12, 2630-2633
DOI: 10.1039/C2LC40331E

Commercialization of microfluidic point-of-care diagnostic devices
Curtis D. Chin, Vincent Linder and Samuel K. Sia
Lab Chip, 2012, 12, 2118-2134
DOI: 10.1039/C2LC21204H

Surface acoustic wave (SAW) acoustophoresis: now and beyond
Sz-Chin Steven Lin, Xiaole Mao and Tony Jun Huang
Lab Chip, 2012, 12, 2766-2770
DOI: 10.1039/C2LC90076A

Lab-in-a-tube: on-chip integration of glass optofluidic ring resonators for label-free sensing applications
Stefan M. Harazim, Vladimir A. Bolaños Quiñones, Suwit Kiravittaya, Samuel Sanchez and Oliver G. Schmidt
Lab Chip, 2012, 12, 2649-2655
DOI: 10.1039/C2LC40275K

Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine
Mais J. Jebrail, Michael S. Bartsch and Kamlesh D. Patel
Lab Chip, 2012, 12, 2452-2463
DOI: 10.1039/C2LC40318H

Droplet microfluidics
Shia-Yen Teh, Robert Lin, Lung-Hsin Hung and Abraham P. Lee
Lab Chip, 2008, 8, 198-220
DOI: 10.1039/B715524G

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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Body heat could drive drug delivery

Micropump yeast body heatAnother Lab on a Chip article has been picked up by the press, describing a nifty micropump which is powered by fermentation of yeast.  Manuel Ochoa and Babak Ziaie, Purdue University, created the “microorganism-powered thermopneumatic pump” by stacking PDMS layers with a silicon substrate drug reservoir and a chamber for the yeast.  They showed that when the yeast ferments under body temperatures, the micropump could displace the drug in the reservoir.  The technology has caused excitement due to its potential for use in transdermal drug delivery patches, by driving tiny microneedle arrays.

A fermentation-powered thermopneumatic pump for biomedical applications
Manuel Ochoa and Babak Ziaie
DOI: 10.1039/C2LC40620A

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Article on light-activated muscle has people twitching

A collaborative study by Harry Asada (MIT) and Roger Kamm (Penn State) and colleagues just published in Lab on a Chip has been causing a bit of a stir on the blogosphere recently.  The article describes the stimulation of muscle, not by electrical signals as used in the body, but by light.  The team engineered skeletal muscle tissue to contain a light-responsive protein, which allowed it to contract when blue light was shone on it, as shown in the video below from the MIT press release:

Jumping straight from this amazing achievement to the future, several blogs have already discussed the potential of this technology for advanced biorobotics  (this article was our favourite).  Professor Asada is a little more modest and discusses the potential of the engineered muscle to control endoscopes or be used in drug screening programmes.

Read the paper here or take a look at some of the posts on the topic:

siliconANGLE
Judgement Day Beckons: Scientists Grow ‘Light-Activated’ Muscle Tissue For Robots

Wired
Light-activated skeletal muscle could be used to make realistic robots

The Verge
Laser-stimulated muscle tissue could be used to build ‘bio-integrated’ robots

Machines like us
Researchers engineer light-activated skeletal muscle

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators
Mahmut Selman Sakar,  Devin M Neal,  Thomas Boudou,  Michael A Borochin,  Yinqing Li,  Ron Weiss,  Roger Kamm,  Christopher S. Chen and H Harry Asada
Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40338B

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Moving microrobots with bubbles

Microrobots smaller than the width of a human hair have been directed to assemble patterns made of single yeast cells and cell-laden agarose microgels using cavitation bubbles by a team from Hawaii. The robots could be used to push cells together to grow artificial tissue.

The microbot manipulating agarose gel blocks, some containing cells, into a 3x4 array

The microbot manipulating agarose gel blocks, some containing cells, into a 3x4 array

There have been a number of different methods used to manipulate single cells into patterns; including micromanipulators, which physically trap and hold cells but need skilled technicians to use them; and optical tweezers, which can be automated but usually need strong lasers or electrical fields that can affect the cells.

Read the full article in Chemistry World.

Or read the Lab on a Chip paper:
Hydrogel microrobots actuated by optically generated vapour bubbles
Wenqi Hu, Kelly S. Ishii, Qihui Fan and Aaron T. Ohta
Lab Chip, 2012,12, 3821-3826
DOI: 10.1039/C2LC40483D

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HOT article: Digital microfluidics for measuring glucose in human blood serum

Hywel Morgan and colleagues at Sharp Laboratories of Europe, the University of Southampton and Sharp Corporation, Japan, demonstrate a large area digital microfluidic array in this HOT article.

Using a thin film transistor (TFT) array rather than the traditional patterned electrodes usually used in electrowetting on dielectric (EWOD) devices, the team developed active matrix electrowetting on dielectric (AM-EWOD) devices. The TFT array enables each of the many thousand electrodes to be individually addressable, and the array is ‘fully reconfigurable and can be programmed to support multiple simultaneous operations’.

Read how the device can be used for measuring glucose in human blood serum in the full article (it’s free to access for four weeks*!):

Programmable large area digital microfluidic array with integrated droplet sensing for bioassays
B. Hadwen, G. R. Broder, D. Morganti, A. Jacobs, C. Brown, J. R. Hector, Y. Kubota and H. Morgan
DOI: 10.1039/C2LC40273D

*Following a simple registration.

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Issue 17 now online

We’ve got another jam-packed issue for you this week, with some colourful articles on the cover from Lee Hubble, Jochen Hoffman and Helena Zec.

On the outside front cover Lee Hubble from CSIRO and colleagues have used functionalised gold nanoparticle chemiresistor sensors to simultaneously perform on-chip protein separation and metabolite detection in biofluids. They were able to avoid problems of protein and lipid-fouling by using ultrafiltration membranes to prevent large molecules interacting with the golf nanoparticle chemiresitor sensors:

Gold nanoparticle chemiresistors operating in biological fluids
Lee J. Hubble, Edith Chow, James S. Cooper, Melissa Webster, Karl-Heinz Müller, Lech Wieczorek and Burkhard Raguse
DOI: 10.1039/C2LC40575J

The inside front cover from Jochen Hoffman and colleagues at University of Freiburg demonstrates an method that combines large scale picowell array-based  liquid phase PCR amplification with solid phase PCR.  The authors have immobilised the PCR products on a microscope slide to enable recovery and achieved single DNA molecule amplification:

Solid-phase PCR in a picowell array for immobilizing and arraying 100 000 PCR products to a microscope slide
Jochen Hoffmann,  Martin Trotter,  Felix von Stetten,  Roland Zengerle and Günter Roth
DOI: 10.1039/C2LC40534B

And on the back cover Helena Zec and colleagues present a droplet platform for generating nanolitre droplets of combinational mixtures.  Sample plugs from a multiwell are split into nanolitre droplets which can be injected with four different reagents – in this paper, food colouring, to prove their concept.  Due to the automatic spatial indexing of the droplets, droplet barcoding is not necessary.

Microfluidic platform for on-demand generation of spatially indexed combinatorial droplets
Helena Zec, Tushar D. Rane and Tza-Huei Wang
DOI: 10.1039/C2LC40399D

Also in this issue we have the latest Research Highlights from Ali Khademhosseini to keep you up to date with the most important miniaturisation research, Acoustofluidics number 17 from Michael Gedge and Martyn Hill and an interesting Focus article from Samuel Stavis on testing standards for lab on a chip devices, as well as plenty of HOT articles.

View the issue

Ps. Don’t forget all our cover articles are free to access for 6 weeks following a simple registration!

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Introducing our new Associate Editor – Dr Jianhua Qin

We at Lab on a Chip are very pleased to announce our newest Associate Editor – Dr Jianhua Qin. Dr Qin is a Professor at the Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS) and is the director of the Microfluidics Research Center at DICP. She joined the team at Lab on a Chip in July.

Dr Jianhua Qin received her M.D. in Medical Science from the China Medical University and her Ph.D in Chemistry from CAS, respectively. She was a Postdoc fellow at the University of Toronto. Dr Qin’s research interests are focused on the combination of microfluidics and nanotechnologies to understand natural and dysfunctional biomed-systems that lead to the design of novel diagnostic schemes and therapeutic strategies. Dr Qin is a professor at the Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS) and is the director of the Microfluidics Research Center at DICP.

Below, Dr Qin shares her views on the growth of microfluidics in China:

Microfluidics has emerged as a distinct new field to greatly influence the multidisciplinary research involved in chemistry, engineering, biology, and physics, as well as medicine. During the last two decades, it has been advancing at a rapid pace, and has found a variety of innovative applications worldwide. In China, only in the past decade, an increased number of scientists from different areas have been getting into this active field, leading to the rapid growth of microfluidics (or lab-on-a-chip) in China. During this period, more than 1900 scientific papers have been published in the international journals indexed in Web of Science, where the term “microfluidic” is used as a searching key word. Since 2002, a series of national and international conferences regarding the topics of micro/nanofluidics (or lab-on-a-chip) have been successfully held in China. These research activities cover subject areas including micro-scale fluidic control/principles, microfabrication technologies/methods, chemical synthesis/analysis, and biological/medical systems et al. It is of note that efforts in recent years have moved from simple technological demonstrations to the exploration of practical applications.

The rapidly proliferating status of this research field in China is mainly attributed to the increasing recognization of microfluidic technologies dedicated to healthcare, and the large amount of funding support from the Chinese government and other resources, including the National Natural Science Foundation of China, the Ministry of Science and Technology of China, the Chinese Academy of Sciences, and industries, etc. This input has greatly facilitated the improvement of research facilities, activities and the cultivation of related academic researchers over many universities and research institutes. Certainly, with the rapid progress in fundamental investigations and the technological development of microfluidics in China, more challenges will be faced and addressed in the near future, such as effective strategies to apply existing microfluidics/LOC methodologies to realistic applications and achieve commercialization.

We are delighted to welcome Dr Qin to the Lab on a Chip Editorial Board as Associate Editor and feel that her expertise will help us to further meet the needs of our authors and readers.

If your research falls under Dr Qin’s area of expertise, why not submit your next article to her?

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Lab on a Chip’s top cited papers from 2009 and 2010

To celebrate last month’s release of the 2011 Impact Factors, we are making some of our best content free to access.

The collection brings together the 20 top cited  Lab on a Chip papers from 2009 and 2010.

View the collection here.

All the articles are free to access for a limited time, following a simple registration for individual users.

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