Lab on a Chip Blog

Lab on a Chip is delighted to share with you our Thematic Collection on droplet-based single-cell sequencing.

The droplet-based single-cell sequencing field is advancing very rapidly. Large numbers of studies are underway to collect and explore the new information that is now accessible with single-cell RNA-seq. Improvements to the microfluidics are also advancing rapidly. This collection of papers and reviews focusses on the between the technological advancements and high impact applications of droplet-based single-cell sequencing.

This topical and exciting collection is collated by Thought leader Dave Weitz and the Lab on a Chip Editorial Board. The collection is introduced in a perspective on single cell sequencing by the Thought leader Dave Weitz, and in two editorials, one on “InDrops and Drop-seq” by Allon Klein and Evan Macosko and one on “an engineer and business person’s perspective” by businessman and engineer Mark Gilligan.

Read the full collection at: http://rsc.li/drop-sc-seq

Below is a selection of content highlights featured in the collection. In addition, all papers are free to read until 31^st May*

Perspective

Droplet-based single cell RNAseq tools: a practical guide

Robert Salomon, David Gallego-Ortega, et al.

Critical Review

Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics

Iain C. Clark and Adam R. Abate

Paper

High throughput gene expression profiling of yeast colonies with microgel-culture Drop-seq

Leqian Liu, Adam R. Abate, et al.

Paper

Simplified Drop-seq workflow with minimized bead loss using a bead capture and processing microfluidic chip

Marjan Biočanin, Bart Deplancke, et al.

Lab on a Chip is the leading journal publishing significant and original work related to miniaturisation, at the micro- and nano-scale, of interest to a multidisciplinary readership with an Journal Impact Factor of 5.995**. The journal is guided by Editor-in-Chief Abraham (Abe) Lee (University of California, Irvine) who is supported by our team of Associate Editors (Yoon-Kyoung Cho, Petra Dittrich, Hang Lu, Jianhua Qin, Manabu Tokeshi, Joel Voldman and Aaron Wheeler).

We hope you enjoy reading the papers within this Thematic Collection and we welcome future submissions on droplet-based single-cell sequencing.

Dolomite/Lab on a Chip Pioneers of Miniaturization Lectureship–deadline approaching-nominate a colleague now!

Organ-on a-chip systems- translating concept into practice thematic collection –Submit now

Organ-,body- and disease-on-a-chip thematic collection –Read now

Personalised medicine:liquid biopsy–Read now

Lab on a Chip Emerging Investigator Series– Apply now

Lab on a Chip is delighted to share with you our Thematic Collection on personalised medicine-liquid biopsy.

This collection of papers and reviews focusses on the interface between the technological advancements and high impact applications of liquid biopsy technologies. This collection is collated by Thought Leaders Mehmet Toner and Stefanie Jeffrey and the Lab on a Chip Editorial Board and is introduced in an Editorial by the Thought Leaders on Liquid biopsy: a perspective for probing blood for cancer. 

Read the full collection at: http://rsc.li/liquid-biopsy

Below is a selection of content highlights featured in the collection. In addition, all papers are free to read until 31^st May*

Tutorial Review

Cancer diagnosis: from tumor to liquid biopsy and beyond

Ramanathan Vaidyanathan, Chwee Teck Lim, et al.

Critical Review

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

Lena Gorgannezhad, Nam-Trung Nguyen, Muhammad J. A. Shiddiky et al.

Paper

Dynamic CTC phenotypes in metastatic prostate cancer models visualized using magnetic ranking cytometry

Leyla Kermanshah, Shana O. Kelley et al.

Paper

An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection

Chen-Yin Ou, Timothy J. Abram, Weian Zhao et al.

Paper

Cancer marker-free enrichment and direct mutation detection in rare cancer cells by combining multi-property isolation and microfluidic concentration

Soo Hyeon Kim, Teruo Fujii et al.

Paper

Urine-based liquid biopsy: non-invasive and sensitive AR-V7 detection in urinary EVs from patients with prostate cancer

Hyun-Kyung Woo, Hong Koo Ha, Yoon-Kyoung Cho et al.

Lab on a Chip is the leading journal publishing significant and original work related to miniaturisation, at the micro- and nano-scale, of interest to a multidisciplinary readership with an Journal Impact Factor of 5.995**. The journal is guided by Editor-in-Chief Abraham (Abe) Lee (University of California, Irvine) who is supported by our team of Associate Editors (Yoon-Kyoung Cho, Petra Dittrich, Hang Lu, Jianhua Qin, Manabu Tokeshi, Joel Voldman and Aaron Wheeler).

We hope you enjoy reading the papers within this Thematic Collection!

Keep up to date with Lab on a Chip throughout the year by signing up for free table of contents alerts and monthly e-newsletters.

Dolomite/Lab on a Chip Pioneers of Miniaturization Lectureship–deadline approaching-nominate a colleague now!

Organ-on a-chip systems- translating concept into practice thematic collection –Submit now

Organ-,body- and disease-on-a-chip thematic collection –Read now

Droplet-based single-cell sequencing– Read now

Lab on a Chip Emerging Investigator Series– Apply now