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Microfluidic sugar paper

03 Jun 2013

Researchers in the US have demonstrated that the speed of fluid in a paper microfluidic device can be controlled by sugar solutions dried onto the paper.

Many chemical tests require washing steps and the addition of reagents in a precisely timed sequence. These steps can be controlled manually, but if they are automated there is less room for human error.

Conceptual illustration (left) and folding card format (right) of paper with dissolvable delays for automated multi-step assay

Read the original Chemistry World article here.

Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics
Barry Lutz, Tinny Liang, Elain Fu, Sujatha Ramachandran, Peter Kauffmana and Paul Yagera
Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50178G

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Top ten most accessed LOC articles in January 2013

25 Mar 2013

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:-

Smart Polymeric Microfluidics Fabricated by Plasma Processing: Controlled Wetting, Capillary Filling, Hydrophobic Valving
Katerina Tsougeni, Dimitris Papageorgiou, Angeliki Tserepi and Evangelos Gogolides
Lab Chip, 2010, 10, 462-469
DOI: 10.1039/B916566E

Probing circulating tumor cells in microfluidics
Peng Li, Zackary S. Stratton, Ming Dao, Jerome Ritz and Tony Jun Huang
Lab Chip, 2013, 13, 602-609
DOI: 10.1039/C2LC90148J

A polymer-based neural microimplant for optogenetic applications: design and first in vivo study
Birthe Rubehn, Steffen B. E. Wolff, Philip Tovote, Andreas Lüthi and Thomas Stieglitz
Lab Chip, 2013, 13, 579-588
DOI: 10.1039/C2LC40874K

Pen microfluidics: rapid desktop manufacturing of sealed thermoplastic microchannels
Omid Rahmanian and Don L. DeVoe
Lab Chip, 2013, 13, 1102-1108
DOI: 10.1039/C2LC41057E

Fundamentals of Inertial Focusing of Microparticles in a Rectangular Microchannel
Jian Zhou and Ian Papautsky
Lab Chip, 2013, 13, 1121-1132
DOI: 10.1039/C2LC41248A

Advances in Microfluidics-based Experimental Methods for Neuroscience Research
Jae Woo Park, Hyung Joon Kim, Myeong Woo Kang and Noo Li Jeon
Lab Chip, 2013, 13, 509-521
DOI: 10.1039/C2LC41081H

Adhesive-based bonding technique for PDMS microfluidic devices
C. Shea Thompson and Adam R. Abate
Lab Chip, 2013, 13, 632-635
DOI: 10.1039/C2LC40978J

Engineered cell culture substrates for axon guidance studies: moving beyond proof of concept
Joannie Roy, Timothy E. Kennedy and Santiago Costantino
Lab Chip, 2013, 13, 498-508
DOI: 10.1039/C2LC41002H

Label-Free DC Impedance-based Microcytometer for Circulating Rare Cancer Cell Counting
Hyoungseon Choi, Kwang Bok Kim, Chang Su Jeon, Inseong Hwang, Saram Lee, Hark Kyun Kim, Hee Chan Kim and Taek Dong Chung
Lab Chip, 2013, 13, 970-977
DOI: 10.1039/C2LC41376K

Microfluidic chemostat for measuring single cell dynamics in bacteria
Zhicheng Long, Eileen Nugent, Avelino Javer, Pietro Cicuta, Bianca Sclavi, Marco Cosentino Lagomarsino and Kevin D. Dorfman
Lab Chip, 2013, 13, 947-954
DOI: 10.1039/C2LC41196B

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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Worried about food allergens? There’s an app for that

12 Dec 2012

Building on their work on a mobile phone – or cell phone – app to detect bacteria, US scientists have now adapted the technology to detect allergens in foods.

The iTube platform uses colorimetric assays and a smartphone to reveal the presence of allergens in food samples

The device, developed by Aydogan Ozcan and his colleagues at the University of California, Los Angeles, is a compact and lightweight attachment for a mobile phone’s camera unit, which is used to image tubes containing food samples illuminated by light emitting diodes. ‘If there is an allergen in the sample, the transmitted light intensity changes,’ says Ozcan. ‘By quantifying the transmitted light intensity using a smart application on the phone, we can quantify the amount of allergen in the sample in parts per million.’

To read the full article, visit Chemistry World.

A personalized food allergen testing platform on a cellphone
Ahmet Coskun, Justin Wong, Delaram Khodadadi, Richie Nagi, Andrew Tey and Aydogan Ozcan
Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC41152K

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Top ten most accessed articles in August 2012

21 Nov 2012

The following articles were in the Lab on a Chip top ten most accessed for the month of August:

Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics
Amir M. Foudeh, Tohid Fatanat Didar, Teodor Veres and Maryam Tabrizian
Lab Chip, 2012, 12, 3249-3266
DOI: 10.1039/C2LC40630F

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices
Philip J. Kitson, Mali H. Rosnes, Victor Sans, Vincenza Dragone and Leroy Cronin
Lab Chip, 2012, 12, 3267-3271
DOI: 10.1039/C2LC40761B

Electrokinetics with “paper-and-pencil” devices
Pratiti Mandal, Ranabir Dey and Suman Chakraborty
Lab Chip, 2012, 12, 4026-4028
DOI: 10.1039/C2LC40681K

Microfluidic evaporator for on-chip sample concentration
Xavier Casadevall i Solvas, Vladimir Turek, Themistoklis Prodromakis and Joshua B. Edel
Lab Chip, 2012, 12, 4049-4054
DOI: 10.1039/C2LC40746A

Joining plasmonics with microfluidics: from convenience to inevitability
Jaeyoun Kim
Lab Chip, 2012, 12, 3611-3623
DOI: 10.1039/C2LC40498B

A novel microfluidic microplate as the next generation assay platform for enzyme linked immunoassays (ELISA)
Junhai Kai, Aniruddha Puntambekar, Nelson Santiago, Se Hwan Lee, David W. Sehy, Victor Moore, Jungyoup Han and Chong H. Ahn
Lab Chip, 2012, 12, 4257-4262
DOI: 10.1039/C2LC40585G

Optical imaging techniques in microfluidics and their applications
Jigang Wu, Guoan Zheng and Lap Man Lee
Lab Chip, 2012, 12, 3566-3575
DOI: 10.1039/C2LC40517B

Concentration gradient generation of multiple chemicals using spatially controlled self-assembly of particles in microchannels
Eunpyo Choi, Hyung-kwan Chang, Chae Young Lim, Taesung Kim and Jungyul Park
Lab Chip, 2012, 12, 3968-3975
DOI: 10.1039/C2LC40450H

Frontiers of optofluidics in synthetic biology
Cheemeng Tan, Shih-Jie Lo, Philip R. LeDuc and Chao-Min Cheng
Lab Chip, 2012, 12, 3654-3665
DOI: 10.1039/C2LC40828G

Electrode-free picoinjection of microfluidic drops
Brian O’Donovan, Dennis J. Eastburn and Adam R. Abate
Lab Chip, 2012, 12, 4029-4032
DOI: 10.1039/C2LC40693D

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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Top ten most accessed articles in July 2012

26 Sep 2012

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:

Microfluidically-unified cell culture, sample preparation, imaging and flow cytometry for measurement of cell signaling pathways with single cell resolution
Meiye Wu, Thomas D. Perroud, Nimisha Srivastava, Catherine S. Branda, Kenneth L. Sale, Bryan D. Carson, Kamlesh D. Patel, Steven S. Branda and Anup K. Singh
Lab Chip, 2012, 12, 2823-2831
DOI: 10.1039/C2LC40344G

Blood separation on microfluidic paper-based analytical devices
Temsiri Songjaroen, Wijitar Dungchai, Orawon Chailapakul, Charles S. Henry and Wanida Laiwattanapaisal
Lab Chip, 2012, 12, 3392-3398
DOI: 10.1039/C2LC21299D

Microfluidic electronics
Shi Cheng and Zhigang Wu
Lab Chip, 2012, 12, 2782-2791
DOI: 10.1039/C2LC21176A

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices
Ju Hun Yeon, Hyun Ryul Ryu, Minhwan Chung, Qing Ping Hu and Noo Li Jeon
Lab Chip, 2012, 12, 2815-2822
DOI: 10.1039/C2LC40131B

High throughput method for prototyping three-dimensional, paper-based microfluidic devices
Gregory G. Lewis, Matthew J. DiTucci, Matthew S. Baker and Scott T. Phillips
Lab Chip, 2012, 12, 2630-2633
DOI: 10.1039/C2LC40331E

Commercialization of microfluidic point-of-care diagnostic devices
Curtis D. Chin, Vincent Linder and Samuel K. Sia
Lab Chip, 2012, 12, 2118-2134
DOI: 10.1039/C2LC21204H

Surface acoustic wave (SAW) acoustophoresis: now and beyond
Sz-Chin Steven Lin, Xiaole Mao and Tony Jun Huang
Lab Chip, 2012, 12, 2766-2770
DOI: 10.1039/C2LC90076A

Lab-in-a-tube: on-chip integration of glass optofluidic ring resonators for label-free sensing applications
Stefan M. Harazim, Vladimir A. Bolaños Quiñones, Suwit Kiravittaya, Samuel Sanchez and Oliver G. Schmidt
Lab Chip, 2012, 12, 2649-2655
DOI: 10.1039/C2LC40275K

Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine
Mais J. Jebrail, Michael S. Bartsch and Kamlesh D. Patel
Lab Chip, 2012, 12, 2452-2463
DOI: 10.1039/C2LC40318H

Droplet microfluidics
Shia-Yen Teh, Robert Lin, Lung-Hsin Hung and Abraham P. Lee
Lab Chip, 2008, 8, 198-220
DOI: 10.1039/B715524G

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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Moving microrobots with bubbles

31 Aug 2012

Microrobots smaller than the width of a human hair have been directed to assemble patterns made of single yeast cells and cell-laden agarose microgels using cavitation bubbles by a team from Hawaii. The robots could be used to push cells together to grow artificial tissue.

The microbot manipulating agarose gel blocks, some containing cells, into a 3x4 array

There have been a number of different methods used to manipulate single cells into patterns; including micromanipulators, which physically trap and hold cells but need skilled technicians to use them; and optical tweezers, which can be automated but usually need strong lasers or electrical fields that can affect the cells.

Read the full article in Chemistry World.

Or read the Lab on a Chip paper:
Hydrogel microrobots actuated by optically generated vapour bubbles
Wenqi Hu, Kelly S. Ishii, Qihui Fan and Aaron T. Ohta
Lab Chip, 2012,12, 3821-3826
DOI: 10.1039/C2LC40483D

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Author Archive

Microfluidic sugar paper

Top ten most accessed LOC articles in January 2013

Worried about food allergens? There’s an app for that

Top ten most accessed articles in August 2012

Top ten most accessed articles in July 2012

Moving microrobots with bubbles

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