Archive for December, 2014

November’s Free HOT Articles

These HOT articles, published in Novemeber 2014 were recommended by our referees and are free* to access for 4 weeks

From cellular lysis to microarray detection, an integrated thermoplastic elastomer (TPE) point of care Lab on a Disc
Emmanuel Roy, Gale Stewart, Maxence Mounier, Lidija Malic, Régis Peytavi, Liviu Clime, Marc Madou, Maurice Bossinot, Michel G. Bergeron and Teodor Veres
Lab Chip, 2015,15, 406-416
DOI: 10.1039/C4LC00947A, Paper

Inkjet-printed microelectrodes on PDMS as biosensors for functionalized microfluidic systems
Jianwei Wu, Ridong Wang, Haixia Yu, Guijun Li, Kexin Xu, Norman C. Tien, Robert C. Roberts and Dachao Li
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01121J, Paper


Electrochemical pesticide detection with AutoDip – a portable platform for automation of crude sample analyses
Lisa Drechsel, Martin Schulz, Felix von Stetten, Carmen Moldovan, Roland Zengerle and Nils Paust
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01214C, Paper


Take a look at our Lab on a Chip 2014 HOT Articles Collection!

*Access is free until 23.01.15 through a publishing personal account. It’s quick, easy and free to register!

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A new challenge for children: getting rid of pathogens from water using microfluidics

The use of microfluidics to test the safety of drinking water is growing increasingly. Although several microfluidic concepts are already shown to detect pathogens in water useful for this industry, the authors of this article focus on the use of such a device for a different audience: young children.  They show that it can be perfectly used as an educational tool to make children more aware of the importance of clean water and the advantages of microfluidics.

In total six modules are developed, each of them having own teaching objectives and materials. The modules can be used separately and both standardized techniques as well as new microfluidic techniques are treated. For instance the use of the microfluidic separation technique deterministic lateral displacement to separate pathogens out of the water is visualized on a macroscale using LEGO® and particles made with FIMO® clay. The good particles are smaller in diameter than the bad ones, making separation in on macroscale using viscous media (in this case shower gel) possible.

A complete activity is made by the authors, that shows a new and original approach to make young children aware of the challenges in science, technology, engineering and mathematics. By using simple components in combination with cartoons and descriptions, the child can remove the bad pathogens from drinking water in about 30 minutes.

For more information, download the full article now – access is free* for a limited time only!

Angry Pathogens, how to get rid of them: introducing microfluidics for waterborne pathogen separation to children
Melanie Jimenez and Helen L.Bridle
DOI: 10.1039/C4LC0944D

* Access is free through a registered RSC account until 23rd January 2015.

About the webwriter

Dr Loes Segerink is an Assistant Professor in the BIOS Lab-on-a-Chip Group at the University of Twente. Read more about her research interests on her homepage.

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New You Tube videos

Acoustofluidic control of bubble size in microfluidic flow-focusing configuration 

 
Rapid and continuous magnetic separation in droplet microfluidic devices 

 
Real-time tracking, retrieval and gene expression analysis of migrating human T cells 

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New You Tube videos

Integrated Perfusion and Separation System for Entrainment of Insulin Secretion from Islets of Langerhans 
 
Microfluidic static droplet array for analyzing microbial communication on a population gradient 
 
A lung-on-chip array with an integrated bio-inspired respiration mechanism 

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New You Tube Videos

Droplet-based microfluidics at the femtolitre scale 

 

Dynamic acoustic field activated cell separation (DAFACS) 


 
Simultaneous metering and dispensing of multiple reagents on passively controlled microdevice solely by finger pressing 

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New You Tube Videos

 A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia 


 

 
Visualization and characterization of interfacial polymerization layer formation 

 

Oxidized Liquid Metal Based Microfluidic Platform for Tunable Electronic Devices Applications 

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Shrinking Lab-on-a-Chip to Lab-in-a-Tube

Throughout a series of Lab on a Chip Focus Articles Samuel Sánchez, research group leader at Max Planck Institute for Intelligent Systems and recently elected as “innovator of the year 2014”, will be highlighting cutting-edge reports based on miniaturized devices that bridge functional materials and bio-related applications. And first up we have…Lab-in-a-Tube!

Lab-on-a-chip already scales down several components and integrates them into one device, but now scientists are working toward shrinking this further to develop entire laboratories inside an ultra-compact architecture such as a small tube. Samuel discusses the concept and advantages of the lab-in-a-tube before highlighting remarkable cell studies that have already been performed using microtubes.

Lab-in-a-tube systems can combine several functionalities such as optical or electrochemical sensing and is therefore used in various detection systems. Samuel describes the developments in this area, leading to the fabrication of a highly sensitive rolled-up optofluidic ring resonator – fully integrated into lab-on-a-chip devices of course!

Label-free detection systems using the lab-in-a-tube concept

Finally, Samuel discusses the challenges of controlling fluid flow at the micro scale and the use of self-powered on-chip micropumps. As one of Samuel’s main interests, catalytic micropumps will be discussed further in an upcoming Focus Article.

Samuel’s full article ‘Lab-in-a-tube systems as ultra-compact devices’ can be downloaded for free* on our website. We hope you enjoy reading his summary of recent advances in this new and exciting concept of chip integration.

Don’t miss Samuel’s next focus article – register for our e-alerts now!

*Access is free through a publishing personal account. It’s quick, easy and free to register.

More about Samuel Sánchez

Samuel earned his PhD in Analytical Chemistry from the Autonomous University of Barcelona in 2008. After a short period as an Assistant Professor, he worked in Japan at the National Institute for Materials Science. In 2010 he moved to the Institute for Integrative Nanoscience at the Leibniz Institute in Dresden where he was leading the “Biochemical Nanomembranes” group. He is now leading the independent research group at the Max Planck Institute for Intelligent Systems. Samuel has received several awards for his work including the Guinness World Record® for “The smallest man-made jet engine” in 2010, the IIN-IFW Research Prize 2011, the ERC-Starting Grant 2012 “Lab-in-a-tube and Nanorobotic Biosensors (LT-NRBS).” Recently, Samuel has been named as Spain’s top innovators under 35 by the Spanish edition of the journal MIT Technology Review.

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October’s HOT Free Articles

These HOT articles, published in October 2014 were recommended by our referees and are free* to access for 4 weeks

Optofluidic lasers with a single molecular layer of gain
Qiushu Chen, Michael Ritt, Sivaraj Sivaramakrishnan, Yuze Sun and Xudong Fan
Lab Chip, 2014,14, 4590-4595
DOI: 10.1039/C4LC00872C, Communication

A self-powered one-touch blood extraction system: a novel polymer-capped hollow microneedle integrated with a pre-vacuum actuator
Cheng Guo Li, Manita Dangol, Chang Yeol Lee, Mingyu Jang and Hyungil Jung
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00937A, Paper


Design of a 2D no-flow chamber to monitor hematopoietic stem cells
Théo Cambier, Thibault Honegger, Valérie Vanneaux, Jean Berthier, David Peyrade, Laurent Blanchoin, Jerome Larghero and Manuel Théry
Lab Chip, 2015,15, 77-85
DOI: 10.1039/C4LC00807C, Paper


Take a look at our Lab on a Chip 2014 HOT Articles Collection!

*Access is free until 5.01.14 through a publishing personal account. It’s quick, easy and free to register!

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Femtofluidic droplet manipulation now possible

We’ve had microfluidics. We’ve even had nanofluidics. But now, scientists have gone a step smaller by pushing femtofluidics into the realms of possibility.

Droplet microfluidics enables assays and reactions to be performed in droplets of reagent that are just a few nanolitres or picolitres in volume. The main advantages of this are that reactions can be performed in a massively parallel manner using hardly any reagent, and further miniaturisation to give femtolitre droplets promises to enable even higher-throughput with even lower reagent use.

Please visit ChemistryWorld to read the full article .

Droplet-based microfluidics at the femtolitre scale*
Marie Leman, Faris Abouakil, Andrew D. Griffiths and Patrick Tabeling
Lab Chip
, 2015, Advance Article
DOI: 10.1039/C4LC01122H

*Access is free through a registered RSC account until 13 November 2014 – click here to register

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