Archive for June, 2011

Issue 12 now available online – focussing on Dutch research

View the issue online here

This month’s issue is the next instalment in our series of 10th anniversary issues, this time focussing on the best new research from the Netherlands.  Sabeth Verpoorte introduces the issue in her Editorial, describing the progression from macro- to microfluidics in this small, but scientifically strong country.

The issue features work on floating electrodes from Albert van den Berg, artificial cilia from P. R. Onck and J. Westerweel, capillary Stokes drift from Dirk van den Ende, microbubble generation from José Gordillo, two-phase flow systems from Sabeth Verpoorte and micromolding from Michiel Kreutzer.

The issue also features HOT articles from Ryan Bailey, Masaya Hagiwara and Daniel Chiu:


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HOT: new driving force for high accuracy microrobot to manipulate single cells

Manipulating cells in microfluidic chips is often accomplished with a magnetically driven microtool (MMT), driven by a permanent magnet.  However MMTs driven by permanent magnets suffer from low positioning accuracy and response speed.  Here, Masaya Hagiwara (Nagoya University) and colleagues have devised a new way of driving MMTs – using a piezoelectric ceramic induce ultrasonic vibration and reduce the effective friction.  The result is a 1.1 mm positioning accuracy of the microrobot, which is 100 times higher than operating without vibration.

This HOT article is featured on the cover of Issue 12 and is free to access for 6 weeks:

On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations
Masaya Hagiwara, Tomohiro Kawahara, Yoko Yamanishi, Taisuke Masuda, Lin Feng and Fumihito Arai
Lab Chip, 2011, 11, 2049-2054
DOI: 10.1039/C1LC20164F

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HOT: detecting CRP over six orders of magnitude using silicon photonic microring resonators

In their recent paper Ryan Bailey and colleagues at the University of Illinois at Urbana-Champaign address the challenge of creating a biomarker assay capable of spanning a clinically relevant dynamic range.  The ability to accurately detect protein biomarkers over a wide dynamic range is extremely important to determine the stage a disease is at, as well as monitoring the effects of any treatments.

They have developed a a silicon photonic microring resonator-based platform that can quantify the cardiovascular risk biomarker C-reactive protein over a dynamic range of six orders of magnitude.  The 3 step assay increases the dynamic range beyond that possible for a single-step assay and also reduces false positive results.

Download the article for the details – the article is currently free to access:

Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads
Matthew S. Luchansky, Adam L. Washburn, Melinda S. McClellan and Ryan C. Bailey
Lab Chip, 2011, 11, 2042-2044
DOI: 10.1039/C1LC20231F

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