A new method to fabricate microwells for lab-on-a-chip scale high-throughput screening is demonstrated in this HOT article. Whereas previous manufacturing processes can be long, costly and require a lot of equipment, this technique is relatively simple and cheap.
By using a laser to pattern a polyester film coated with silicone glue, Ali Khademhosseini, Harvard-MIT, and colleagues have successfully demonstrated the fabrication of hundreds of microwells in a matter of minutes. The diameter of the microwells can be controlled by adjusting laser speed and power, and the well depth can be increased by stacking layers of film.
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Microfabricated polyester conical microwells for cell culture applications
Šeila Selimović, Francesco Piraino, Hojae Bae, Marco Rasponi, Alberto Redaelli and Ali Khademhosseini
Lab Chip, 2011, Advance Article
DOI: 10.1039/C1LC20213H
