Author Archive

Antihypertensive properties of food-derived food peptides

C2FO10192KHigh blood pressure, known as the ‘silent killer’ is a significant health problem worldwide contributing to an increased risk for heart attack or stroke.  There are numerous preventative and therapeutic drug treatments as well as dietary compounds that have been identified as contributing to cardiovascular health. 

Food-protein derived peptides which have antihypertensive properties have recently received special attention; however, most of their properties have been demonstrated in vitro.  To be confident of the potential these peptides have in cardiovascular health the beneficial effects must be demonstrated in vivo and in clinical trials. 

This review from Blanca Hernández-Ledesma and co-workers from the Institute of Food Science Research in Madrid, Spain, looks at the current state of the data on blood pressure-lowering activity of food-derived peptides demonstrated in vivo through animal models and humans. Other key roles of these peptides such as the mechanism of action and bioavailability are also summarised.

Interested in knowing more?  Read the full article for free until 21st February:

Antihypertensive peptides from food proteins: a review
Daniel Martínez-Maqueda, Beatriz Miralles, Isidra Recio and Blanca Hernández-Ledesma
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10192K

You may also be interested in this review on the role of milk pepetides in cardiovascular health which is freely available:

The potential role of milk-derived peptides in cardiovascular disease
Martha Phelan and David Kerins
Food Funct., 2011, 2, 153-167, DOI: 10.1039/C1FO10017C

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First issue of 2012 now online!

Food & Function Volume 3, Issue 1 is now online, this issue is completely free to access (upon registration).  You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and our monthly e-newsletter ‘food for thought’.Volume 3 Issue 1 Cover

The front cover of this issue presents a review article from Uri Lesmes and co-workers at Technion – Israel Institute of Technology, ‘Development of oral food-grade delivery systems: Current knowledge and future challenges’. There has, in recent years, been an increasing interest in the development of new and efficient oral food delivery systems as tools to prevent disease and promote human health and well-being, and although considered to be still in its infancy, this promising field of research is likely to infiltrate into real products through rational design. In order for such efforts to materialize into real products some challenges still need to be met and are discussed in this review which summarises the key concepts of food delivery systems, their characterization and their evaluation. In particular, evaluation of their performance within the human gastrointestinal tract is discussed.

Read the full article by clicking on the title below and read the full issue here:

Development of oral food-grade delivery systems: Current knowledge and future challenges
Revital Cohen Benshitrit, Carmit Shani Levi, Sharon Levi Tal, Eyal Shimoni and Uri Lesmes
Food Funct., 2012, 3, 10-21 DOI: 10.1039/C1FO10068H

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Volumes 1 & 2 of Food & Function free to access

As Food & Function enters its 3rd year of publication we are pleased to announce that volumes 1 & 2 are now free to access (upon registration).  The Journal has published some excellent work from top researchers in the field over the past two years; simply visit our website to read it all for free. 

To get you started here are the 10 most downloaded articles since our launch in October 2010.

Espresso coffees, caffeine and chlorogenic acid intake: potential health implications
Thomas W. M. Crozier, Angelique Stalmach, Michael E. J. Lean and Alan Crozier
Food Funct., 2012, Advance Article, DOI: 10.1039/C1FO10240K

Anti-inflammatory activity of natural dietary flavonoids
Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho
Food Funct., 2010, 1, 15-31, DOI: 10.1039/C0FO00103A

Review of in vitro digestion models for rapid screening of emulsion-based systems
David Julian McClements and Yan Li
Food Funct., 2010, 1, 32-59, DOI: 10.1039/C0FO00111B

Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices
Gina Borges, William Mullen and Alan Crozier
Food Funct., 2010, 1, 73-83, DOI: 10.1039/C0FO00008F

Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds
Wasaporn Chanput, Jurriaan Mes, Robert A. M. Vreeburg, Huub F. J. Savelkoul and Harry J. Wichers
Food Funct., 2010, 1, 254-261, DOI: 10.1039/C0FO00113A

Red wine: A source of potent ligands for peroxisome proliferator-activated receptor γ
Alfred Zoechling, Falk Liebner and Alois Jungbauer
Food Funct., 2011, 2, 28-38, DOI: 10.1039/C0FO00086H

Bioactive peptides derived from milk proteins and their health beneficial potentials: an update
Ravinder Nagpal, Pradip Behare, Rajiv Rana, Ashwani Kumar, Manoj Kumar, Sanu Arora, Fransesco Morotta, Shalini Jain and Hariom Yadav
Food Funct., 2011, 2, 18-27, DOI: 10.1039/C0FO00016G

Inhibition of advanced glycation endproduct formation by foodstuffs
Chi-Hao Wu, Shang-Ming Huang, Jer-An Lin and Gow-Chin Yen
Food Funct., 2011, 2, 224-234, DOI: 10.1039/C1FO10026B

Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides
Purnima Gunness and Michael John Gidley
Food Funct., 2010, 1, 149-155, DOI: 10.1039/C0FO00080A

Expression of carotenoid biosynthetic pathway genes and changes in carotenoids during ripening in tomato (Lycopersicon esculentum)
Kanakapura Krishnamurthy Namitha, Surya Narayana Archana and Pradeep Singh Negi
Food Funct., 2011, 2, 168-173, DOI: 10.1039/C0FO00169D

Volume 1 Issue 1 ofc

Volume 1 Issue 1

Food & Function Volume 2 Issue 1 cover

Volume 2 Issue 1

Volume 3 Issue 1 cover

Volume 3 Issue 1

Keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters!

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Polyphenol levels in nuts (especially walnuts) are high, and they exhibit significant potential health benefits

In human supplementation studies nuts have been shown to improve the lipid profile, increase endothelial function and reduce inflammation, all without causing weight gain.  They have a favourable fatty acid profile with low saturated fats and high PUFA which provides a rationale for the some of these effects, however, the benefits seen in these trials are greater than what would be predicted based on the amount and nature of fat consumed.  This suggests other bioactive constituents are present – but what are they?

Daily per capita contribution of polyphenols from food sources to the US diet in 2008.Joe Vinson and Yuxing Cai have tested the hypothesis that the mystery bioactive compounds are polyphenols.  This hypothesis is supported by a body of work showing nuts have antioxidant capacity.

The team from the University of Scranton in the USA measured polyphenol levels in nuts and found that walnuts had the highest free and total polyphenols.  Furthermore, total polyphenols in the nuts was significantly higher than free polyphenols and roasting had little effect on the polyphenol levels.  The team also investigated the efficacy of nut antioxidants and showed that walnut extracts were superior in binding lower density lipoprotein and inhibiting its oxidation than other nuts.  However, all nuts are high in polyphenol antioxidants which by binding to lipoproteins inhibit oxidative processes that lead to atheroscelrosis in vivo.

Finally, the team then used their findings on polyphenol levels in nuts and per capita consumption data to calculate the contribution of nuts to the daily antioxidant intake in the US diet.  They show that nuts represent 19% of the food and beverage polyphenols in the average US diet.

Interested in knowing more?  Read the full article for free until the end of January 2012.

Nuts, especially walnuts, have both antioxidant quantity and efficacy and exhibit significant potential health benefits
Joe A. Vinson and Yuxing Cai
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10152A

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Make the most of the last month of free access to Food & Function

Free online access to Food & Function will finish at the end of 2011, but there is still time to take a look at all the articles we’ve published so far free of charge.

Don’t know where to start?  Why not take a look at some of the top accessed articles over the last year:

Graphical abstract: Espresso coffees, caffeine and chlorogenic acid intake: potential health implicationsEspresso coffees, caffeine and chlorogenic acid intake: potential health implications
Thomas W. M. Crozier, Angelique Stalmach, Michael E. J. Lean and Alan Crozier
Food Funct., 2012, Advance Article, DOI: 10.1039/C1FO10240K

Anti-inflammatory activity of natural dietary flavonoids
Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho
Food Funct., 2010, 1, 15-31, DOI: 10.1039/C0FO00103A

Graphical abstract: Anti-inflammatory activity of natural dietary flavonoidsTranscription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds
Wasaporn Chanput, Jurriaan Mes, Robert A. M. Vreeburg, Huub F. J. Savelkoul and Harry J. Wichers
Food Funct., 2010, 1, 254-261, DOI: 10.1039/C0FO00113A

Review of in vitro digestion models for rapid screening of emulsion-based systems
David Julian McClements and Yan Li
Food Funct., 2010, 1, 32-59, DOI: 10.1039/C0FO00111B

Graphical abstract: Bioactive peptides derived from milk proteins and their health beneficial potentials: an updateBioactive peptides derived from milk proteins and their health beneficial potentials: an update
Ravinder Nagpal, Pradip Behare, Rajiv Rana, Ashwani Kumar, Manoj Kumar, Sanu Arora, Fransesco Morotta, Shalini Jain and Hariom Yadav
Food Funct., 2011, 2, 18-27, DOI: 10.1039/C0FO00016G

Inhibition of advanced glycation endproduct formation by foodstuffs
Chi-Hao Wu, Shang-Ming Huang, Jer-An Lin and Gow-Chin Yen
Food Funct., 2011, 2, 224-234, DOI: 10.1039/C1FO10026B

Safety assessment of plant food supplements (PFS)
Suzanne J. P. L. van den Berg, Lluis Serra-Majem, Patrick Coppens and Ivonne M. C. M. Rietjens
Food Funct., 2011, 2, 760-768, DOI: 10.1039/C1FO10067J

Graphical abstract: Red wine: A source of potent ligands for peroxisome proliferator-activated receptor γConjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo
Junji Terao, Kaeko Murota and Yoshichika Kawai
Food Funct., 2011, 2, 11-17, DOI: 10.1039/C0FO00106F

Expression of carotenoid biosynthetic pathway genes and changes in carotenoids during ripening in tomato (Lycopersicon esculentum)
Kanakapura Krishnamurthy Namitha, Surya Narayana Archana and Pradeep Singh Negi
Food Funct., 2011, 2, 168-173, DOI: 10.1039/C0FO00169D

Red wine: A source of potent ligands for peroxisome proliferator-activated receptor γ
Alfred Zoechling, Falk Liebner and Alois Jungbauer
Food Funct., 2011, 2, 28-38, DOI: 10.1039/C0FO00086H

If you would like to continue to receive access to Food & Function in 2012 please contact our sales team and ask for a quote.

You can keep up to date with the latest articles and developments from Food & Function by signing up for free table of contents alerts and e-newsletters. Additionally, why not consider submitting your next manuscript to the journal?

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Food & Function article recieves extensive press coverage

Telegraph CoffeeAn article published in Food & Function this week by Professor Alan Crozier and colleagues at the University of Glasgow received extensive coverage in the mainstream UK media yesterday following a press release from the RSC.  The article shows that caffeine levels in espresso coffees purchased from coffee shops vary extensively and some are well above the recommended daily allowance set by the Food Standards Agency unwittingly putting those at risk from excessive caffeine consumption, such as pregnant women and those with liver disease, at risk.

The article received coverage in a number of UK newspapers including The Guardian, The Daily Telegraph, The Mirror and The Daily Mail.  It was also covered on television news outlets including Channel 4 and the BBC.  Why not visit the BBC website where you can see Professor Crozier speaking about his research.

Read the full article by clicking on the title below:

Espresso coffees, caffeine and chlorogenic acid intake: potential health implications
Thomas W. M. Crozier, Angelique Stalmach, Michael E. J. Lean and Alan Crozier
Food Funct., 2012, Advance Article, DOI: 10.1039/C1FO10240K, Paper

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Themed Issue on Plant Food Supplements Now Online

Food & Function Issue 12 is dedicated to a detailed analysis of regulatory, scientific and technical issues concerning safety, quality and efficacy of plant food supplements (PFS).  Guest Editors Patrizia Restani and Vittorio Silano introduce the themed issue in their editorial which you can read here.

Plant Food Supplements CoverRead the full issue on Plant Food Supplements online here. 

Or choose a paper to read by clicking on the titles below:

  1. Regulations applicable to plant food supplements and related products in the European Union
  2. Botanical species being used for manufacturing plant food supplements (PFS) and related products in the EU member states and selected third countries
  3. Plant food supplement (PFS) market structure in EC Member States, methods and techniques for the assessment of individual PFS intake
  4. Quality control of plant food supplements
  5. An overview of consumer attitudes and beliefs about plant food supplements
  6. Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials
  7. Safety assessment of plant food supplements (PFS)
  8. The PlantLIBRA Project: how we intend to innovate the science of botanicals
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Food & Function Issue 11 now online

Issue 11 ofcFood & Function issue 11 is now online and features some exciting new contributions to the field. The front cover highlights an article from Yael Vodovotz and co-workers from Ohio, USA. Their study demonstrates that the addition of soy ingredients to a soft pretzel significantly decreased the glycemic index while maintaining acceptability and satiety. The consumption of nutrient-poor snack foods in western diets is thought to be contributing to the increasing prevalence of obesity and diabetes. The results from this study show that soy offers the potential to produce a more healthful nutritional profile to snack foods. To find out more read the full article ‘A comparison of satiety, glycemic index, and insulinemic index of wheat-derived soft pretzels with or without soy’.

Issue 11 ifcThe inside front cover highlights a review article from Luis Videla and Rodrigo Valenzuela from Chile on the development of non-alcoholic fatty liver associated with obesity. NAFLD is the most important cause of chronic liver disease; the mechanisms underlying hepatic steatosis in obese NAFLD patients are multifactorial and are beginning to be understood. This review addresses the decrease in the n-6/n-3 polyunsaturated fatty acid ratio as a factor playing a significant role in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). To find ou more read the full article ‘The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity’.

Remember that all content in Food & Function is free for all to access until the end of 2011. Read issue 11 and access all content online here.

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Food & Function Issue 10 Now Online

Food & Function Issue 10 front coverFood & Function issue 10 is now online. The front cover features an image of lowbush blueberries representing work by Xianli Wu and co-workers from Arkansas, US. 

The study, recently highlighted on this blog, investigates the mechanisms by which lowbush blueberries exert their cardioprotective effects.  It is revealed that blueberries inhibited expression of CD36 and SR-A in macrophages of apoE−/− mice, through down-regulating PPARγ and reducing its endogenous ligands. 

To find out more read the full article ‘Lowbush blueberries inhibit scavenger receptors CD36 and SR-A expression and attenuate foam cell formation in ApoE-deficient mice‘.

Read Food & Function issue 10 online here.

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Food & Function Issue 9 online now!

Food & Function Issue 9 front coverFood & Function issue 9 is now online.  The front cover represents work from Ashok K. Tiwari and co-workers from the Indian Institute of Chemical Technology (CSIR) in Hyderabad.  Food & Function issue 9 inside coverTheir article ‘Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats’ analyses the major chemical components and multiple antioxidant activities present in the fresh juice of eight vegetables and looks at their influence on starch induced postprandial glycemia in rats.  They find that high polyphenol content in vegetable juice adversely affects the postprandial antihyperglycemic activity of vegetable juices.  To find out more read the full article for free here.

The inside cover highlights the review ‘Natural salicylates: foods, functions and disease prevention’.  Regular intakes of Aspirin™ decrease the risk of developing several diseases therefore it is thought that salicylates in foods may similarly benefit health. In this review Garry Duthie and Adrian Wood from the University of Aberdeen in Scotland review the evidence.  Read the full article for free here.

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