Scientists in Taiwan and the US have investigated the effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Antiadipogenic compounds are important compounds for the control of obesity as they inhibit the formation of fatty tissues. By controlling obesity this can also mediate other health problems associated with the condition, such as type 2 diabetes, cardiovascular disease and cancer.
In this study, 3T3-L1 preadipocytes, 3T3-L1 differentiation- phase adipocytes, and mature 3T3-L1 adipocytes were used to investigate antiproliferation and adipogenesis in vitro. It was found that garcinol, a benzophenone found in mangosteen, and pterostilbene commonly found in grapes, wines and berries, both inhibit cell proliferation and adipogenesis in 3T3-L1 cells. Garcinol also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin and fatty acid synthase. This suggests that garcinol and pterostilbene have anti-adipogenic effects on fat cells.
To read the free article in full, click the link below:
Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells, Chin-Lin Hsu, Yu-Jyun Lin, Chi-Tang Ho and Gow-Chin Yen, Food Funct., 2011, DOI: 10.1039/c1fo10209e
