Archive for September, 2010

Interview: We are what we eat

Gary Williamson, Editor in Chief of Food & Function, talks to Kathleen Too about low dose long term nutrition studies, EU regulators and challenges faced by scientists in food industry and academia.

Gary Williamson Gary Williamson is Professor of Functional Food at the University of Leeds, UK where his research interests lie in nutritional and food biochemistry. Before joining the university in 2007, he was head of the nutrient bioavailability group at the Nestle Research Center in Lausanne, Switzerland. He is also editor-in-chief for Food & Function, a new journal from RSC Publishing.
 

How did you become interested in food science research?

After completing my PhD and postdoc in biochemistry, I went to work for the Institute of Food Research in Norwich and gradually became more and more interested in plants and secondary metabolites and their biological activity. Eventually, this led to more studies on functional foods and their biochemical aspects. I have to say also, that I really enjoy good food. So food research has always been one of my main personal interests.

Your research focuses on functional foods and nutraceuticals, can you explain what these terms mean?

Functional foods are foods that have an activity above and beyond basic nutrition. Nutraceuticals tend to cover food extracts and supplements with a biological activity or with a proposed biological activity.

You’ve worked in both industry and academia, what are the different challenges facing scientists in these areas?

In industry, one problem is that there is a perceived bias in your research. If a company is doing a study on a particular product, then it is seen by the outside world that the company will do all it can for this product to succeed. But, actually, when I was at Nestlé, I can safely say that a lot more evidence was required to prove the benefit of a particular food to convince the managers to believe in the product. So in industry, the scientists are a lot more critical in the initial stages of a discovery and the perceived bias from the outside world is often not correct. In industry, you have less freedom to do research but more resources are available compared to academia. Sometimes, in industry, the scientists themselves can have different goals to the company goals. In academia, the biggest challenge is the money. Always money!

What kind of research do you think food industry should be funding?

Generally, the food industry has a preference for short term studies. But these may not give them the results that they like. It would be really good if industry could fund longer term studies, lasting years rather than weeks, in human nutrition. It is important to do long term low dose studies which are more difficult to conduct and to obtain measurable effects. Most scientists do pharmaceutical-type studies which are acute and high dose studies. The main challenge is to find new techniques that would allow us to do these long term low dose studies. People eat and drink all the time, so how do we study the effects of what they have been eating or drinking all their life? This is the main challenge.

How long does it take from the conception of an idea to its commercialisation?

What are the main barriers to overcome? It always takes too long to commercialise a product especially from the point of view of non-scientists in industry, such as managers and marketing people. It can take anywhere between 2 and 20 years. The main issue is not how long it takes but the different expectations of the different people on the project. That’s why marketing people have to understand that science is slow and painstaking and the scientists have to understand that marketing people cannot wait as long as they want them to wait. The other barrier is the regulators who are becoming stricter all the time. They are trying to apply the rules from the pharmaceutical industry to that of nutrition and I think that it is never going to work like that. Regulatory hurdles are becoming greater and if they are not careful, they may well strangle the science.

Why did you leave industry?

I left industry because I was keener to work on my own research and not necessarily on a specific product. I wanted to be in a university environment with PhD students and surrounded by the general ‘university expertise’. Also I reached the level I could in industry without going into more managerial roles and away from research, which I did not want to do.

What are your tips to become a successful scientist?

The bottom line is look after the people that work for you and motivate them to be at their best. The success of every project is a team effort. If you do not invest time in the people you work with, then they do not get the best out of the work and they do not get to discuss their ideas with you. My approach is to try to get them to do the best job they can and to do a first class thesis. This would benefit them for the rest of their life and also me in advancing my research.

As the editor-in-chief for the new RSC journal Food & Function, could you comment on the aims of this journal?

There is a real need for a new journal focussing on the novel aspects of food and nutrition and not just the conventional nutrition research that has been around for decades but covers some of the newer ideas of how food affects the health and how we can modify its structure to improve its health aspects.

If you weren’t a scientist, what would you do?

I am a keen photographer so maybe I would have my own photography company. Alternatively, I would like to think that I could have been a good barrister.

Also of interest

Food & Function: A new peer-reviewed journal linking the chemistry and physics of food with health and nutrition. Simply register to access all the Food & Function articles for free.

Chemistry for a healthy diet: Interview with Cesar Fraga, Associate Editor of Food & Function

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

How do onions help our heart?

Hypocholesterolemic activity of onion is mediated by enhancing excretion of fecal sterols in hamstersThey may make us cry but onions are actually good for us, and researchers in China are beginning to explain why…

Lei Guan, Hau Yin Chung*, Yalun Su,
Rui Jiao, Cheng Peng and Zhen Yu Chen*
Food & Funct., 2010, Advance Article
DOI: 10.1039/C0FO00036A, Paper

 Levels of plasma total cholesterol (TC) correlate directly with the risk of coronary heart disease, one of the biggest killers worldwide.  Previous studies have shown that onion favourably modifies TC levels, but the underlying mechanism is not understood. 

Hau Yin Chung, Zhen Yu Chen and co-workers studied the effect of dietary onion powder with the protein expression of key receptors and enzymes involved in cholesterol metabolism.  Results demonstrated that onion decreased plasma TC in a dose-dependent manner, accompanied by enhanced excretion of fecal sterols.

Expression analysis demonstrated an upregulation in the expression of liver X receptor-alpha (LXRα), a protein which activates the production of cholesterol-7α-hydroxylase (CYP7A1).  CYP7A1 is a rate-limiting enzyme in the conversion of cholesterol to bile acids and is responsible for the elimination of excessive cholesterol in the liver.  This study shows that it is the upregulation of CYP7A1 which is most likely to explain the decreased plasma TC and enhanced fecal sterol excretion.

Interested in knowing more?  Read the full article here.

Simply register to access all the Food & Function articles for free.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

First Food & Function articles are published

The first Food & Function articles are now online. I hope you enjoy reading these first articles and more will follow very shortly, with the first issue of the Journal being published in October.

Some of the first papers published include:

Anti-inflammatory activity of natural dietary flavonoids by Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho

Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices by Alan Crozier, Gina Borges and William Mullen

Hypocholesterolemic Activity of Onion Is Mediated by Enhancing Excretion of Fecal Sterols in Hamsters by Zhen-Yu Chen, Lei Guan, Hau Yin Chung, Yalun Su, Rui Jiao and Cheng Peng

Read all of the Food & Function articles online.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Keep up to date with news from Food & Function

Food for Thought is the quarterly newsletter that will keep you up to date with all of the latest news from Food & Function.

 

Sign up for Food for Thought today!

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free access to Food & Function

Articles published in Food & Function will benefit from maximum visibility with free access to content published during 2010 and 2011.

To access the 2010 and 2011 Food & Function content  you will need to register for a personal account.

Setting up an account is simple – all we ask is that you provide some very basic information, including a valid email address for authentication.

So don’t delay – register today.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Submit your work to Food & Function

We invite you to submit your work to Food & Function.

Monthly issues of Food and Function will publish communications and full papers reporting primary research as well as in-depth reviews focusing on the interaction of food components with the human body.

Submissions to Food & Function are handled fairly, quickly and efficiently by our Associate Editors, Steven Feng Chen from the University of Hong Kong, and Cesar Fraga from the University of Buenos Aires and UC Davis.

Steven Feng Chen, Associate Editor

Cesar Fraga, Associate Editor

 
Food & Function provides authors in this field with a new dedicated Journal characterised by the high quality, rapid publication and innovative technology for which RSC journals are renowned. In addition authors can expect:
  • Free use of colour where it enhances the article
  • Rigorous peer review by experts in the field
  • Simple and effective online submission process
  • No page charges
  • Free electronic reprints (pdf) of own paper
  • Electronic supplementary information
  • Free e-mail alerting and RSS news feeds service
  • Additional publishing options via RSC Open Science   

We look forward to receiving your submission to Food & Function

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)