Scientists from Germany have designed a new complex which inhibits enzymes and reduces tumour cell growth.
The drug complex consists of N-heterocyclic carbene ligands coordinated to a ruthenium metal centre. Ruthenium N-heterocyclic carbene compounds are largely popular due to their catalytic properties but very little attention has been paid to the biological activity of these species.
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Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules
Luciano Oehninger, Maria Stefanopoulou, Hamed Alborzinia, Julia Schur, Stephanie Ludewig, Kazuhiko Namikawa, Alvaro Muñoz-Castro, Reinhard W. Köster, Knut Baumann, Stefan Wölfl, William S. Sheldrick and Ingo Ott