In this Dalton Transactions Hot Article, chemists from Australia and the US have studied the solution behaviour of two novel platinum-based antitumour complexes.
The dinuclear, polyamine-linked complexes show significant cytotoxicity and antitumour activity compared to other polynuclear platinum complexes.
The rate constants for hydrolysis of the two complexes and the acid dissociation constants of the aquated aqua ligands of their aquated derivatives are reported. The values are of interest because the aquated species are more reactive than their hydroxo counterparts in the context of DNA binding.
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Solution studies of dinuclear polyamine-linked platinum-based antitumour complexes
Rasha A. Ruhayel, Ibrahim Zgani, Susan J. Berners-Price and Nicholas P. Farrell
Dalton Trans., 2011, Advance Article
DOI: 10.1039/C1DT00001B, Paper
