Hypoxia activated prodrugs target regions of tumor hypoxia within tumor cells. In this paper David Ware and colleagues investigate new cobalt cylen-based complexes containing the cytotoxic ligand, 8-quinolinate – a study which lays the groundwork for preparation of radiation-activated hypoxia activated prodrugs.
Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs
John Yu-Chi Chang, Ralph J. Stevenson, Guo-Liang Lu, Penelope J. Brothers, George R. Clark, William A. Denny and David C. Ware
Dalton Trans., 2010, Advance Article
DOI: 10.1039/C0DT01142H , Paper
