The 2011 issue with the most downloads per article is the C-H Functionalisation in Organic Synthesis themed issue (issue 4).
The issue is guest edited by Professors Huw Davies, Justin Du Bois and Jin-Quan Yu and is dedicated to the memory of Professor Keith Fagnou.
C-H Functionalisation in Organic Synthesis hosts a collection of 13 Tutorial and Critical Reviews from leading scientists such as Robert Crabtree, Phil Baran, and John Hartwig. Visit the C-H Functionalisation in Organic Synthesis web page to see what this issue has on offer…
Also of interest… Chem Soc Rev fact numbers 1, 2, 3, 4, 5, 6, 7.