Archive for the ‘Themed Issue’ Category

HOT Communication: Enhancing the clinical performance of tadalafil through crystal engineering

Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid were investigated.

Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid were investigated.

A team from the United States report their study on the hydrogen bonding motifs in tadalafil cocrystals with the aim to produce a drug with enhanced solubility for better oral drug absorption.  Tadalafil, currently used for the treatment of erectile dysfunction, is being explored as a treatment for pulmonary arterial hypertension so would be more useful for this application if the time taken to reach its peak plasma concentration was shorter.

To find out more, download this CrystEngComm communication today…

Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs
David R. Weyna, Miranda L. Cheney, Ning Shan, Mazen Hanna, Lukasz Wojtas and Michael J. Zaworotko
CrystEngComm, 2012
DOI: 10.1039/C2CE06574F

The communication by Zaworotko et al. will be published later in the year as part of a themed issue on crystal engineering in the pharmaceutical industry.  Below is a selection of papers also due to be included in this themed issue:

Covalent assistance to supramolecular synthesis: modifying the drug functionality of the antituberculosis API isoniazid in situ during co-crystallization with GRAS and API compounds
Andreas Lemmerer
CrystEngComm, 2012
DOI: 10.1039/C1CE06310C

Effect of dehydration on the mechanical properties of sodium saccharin dihydrate probed with nanoindentation
M. S. R. N. Kiran, Sunil Varughese, U. Ramamurty and Gautam R. Desiraju
CrystEngComm, 2012
DOI: 10.1039/C1CE05656E

Solid state chemistry of the antibiotic doxycycline: structure of the neutral monohydrate and insights into its poor water solubility
Alexandre O. Legendre, Laila R. R. Silva, Douglas M. Silva, Iara M. L. Rosa, Lilian C. Azarias, Polyana J. de Abreu, Magali B. de Araújo, Person P. Neves, Claudia Torres, Felipe T. Martins and Antonio C. Doriguetto
CrystEngComm, 2012
DOI: 10.1039/C1CE06181J

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Hot Communication: Selective co-crystal formation to remove impurities

Kay Huai-Ying Hsi and colleagues from Massachusetts Institute of Technology detail a strategy for using co-crystallization as a purification method that could be developed for use during the synthesis and manufacturing of pharmaceutical substances and fine chemicals.

This communication will be published as part of a themed issue on crystal engineering and crystallography in the pharmaceutical industry later in the year.  It’s currently free so do take a look!

Separation of impurities from solution by selective co-crystal formation
Kay Huai-Ying Hsi, Keith Chadwick, Amanda Fried, Meghan Kenny and Allan S. Myerson
CrystEngComm, 2012
DOI: 10.1039/C1CE06358H

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Call for papers: Ionic Liquids Themed Issue

We are pleased to announce an upcoming themed issue focussing on ionic liquids, with guest editors Mark Muldoon, Peter Nockemann and Cristina Lagunas-Castedo based at Queen’s University, Belfast. It is our pleasure to invite you to contribute to this themed issue.

The unique physical and chemical properties of ionic liquids as solvents and the potential to tune and control these properties by selecting the appropriate cations and anions, make ionic liquids remarkably versatile for many applications. Recent publications demonstrate their increasing impact on crystal engineering, on materials and nanoscale synthesis, as well as for crystallisation processes.

Contributions in both experimental and theoretical aspects are most welcome. Ideally, contributions should be within the scope of a) the use of ionic liquids as solvents for crystallisation processes; b) ionic liquids for the synthesis of nanocrystalline materials and porous materials; c) the use of ionic liquids for co-crystallisation or crystal structures of ionic liquid salts (including pharmaceutically relevant compounds and metal-containing ionic liquids); d) theoretical studies (for example understanding solid/liquid phase transitions).

How to submit?

All types of manuscript, Communications, Full Papers and Highlights will be considered for publication. We aim to publish this themed issue in late summer 2012 and therefore would like to receive manuscripts by 8th February 2012. The manuscript should be prepared according to the format for regular articles and should be submitted via our online system. All invited manuscripts will be subjected to the normal refereeing procedure.

Deadline for Submission: 8th February 2012

Please indicate on submission that your manuscript is intended for this themed issue and direct any questions to the CrystEngComm Editorial Office.

We invite you to also check out previous themed issues featuring in CrystEngComm. Read them here now.

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Themed issue: Dynamic behaviour and reactivity in crystalline solids

CrystEngComm‘s themed issue on Dynamic behaviour and reactivity in crystalline solids is now online!

The issue is guest edited by Graeme Day and Tomislav Friščić from Cambridge University. Read their editorial, Dynamic behaviour in the solid state.

An editorial by Prof Sir John Meurig Thomas is also included in the issue, and his perspective on Crystal engineering: origins, early adventures and some current trends, is well worth reading.

Other articles include:

Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid
Pawel Grobelny, Arijit Mukherjee and Gautam R. Desiraju

Are glycine cyclic dimers stable in aqueous solution?
Said Hamad and C. Richard A. Catlow

Solid-state synthesis of mixed trihalides via reversible absorption of dihalogens by non porous onium salts
L. Meazza, J. Martí-Rujas, G. Terraneo, C. Castiglioni, A. Milani, T. Pilati, Pierangelo Metrangolo and Giuseppe Resnati

View all the articles in Issue 13, 2011.

Find out more about our guest editors by visiting their websites (Dr Day, Dr Friščić,) or reading this CrystEngCommunity interview with Graeme Day.

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Establishing mechanisms of solid state double [2 + 2] photochemical reactions

A double [2 + 2] photochemical reaction of 1,5-bis(4-pyridyl)-1,4-pentadiene-3-one (1P) was observed with in four co-crystal forms of 1P with the hydrogen bonding template molecule phloroglucinol (PG) or 5-methoxy resorcinol (MR). 1H NMR and the UV-vis spectroscopic studies established a stepwise mechanism for this reaction through the formation of a monocyclobutane intermediate.

Read more at:

Solid state double [2 + 2] photochemical reactions in the co-crystal forms of 1,5-bis(4-pyridyl)-1,4-pentadiene-3-one: establishing mechanism using single crystal X-ray, UV and 1H NMR
Ramkinkar Santra and Kumar Biradha
CrystEngComm, 2011, Advance Article
DOI: 10.1039/C0CE00612B

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Cover article: Crystal engineering for improved drug performance

Check out the latest cover for CrystEngComm issue 4 published online now:

COVER ARTICLE

CEC issue 4 cover image

Crystalline hydrates and propylene glycol solvates of celecoxib sodium salt (Cel-Na) were prepared and characterized with the aim of improving oral drug absorption by breaking up the H-bonding interactions present in crystals of the poorly soluble marketed form of the drug.

Read more at:
Remenar et al., CrystEngComm, 2011, 13, 1047-1048

DOI: 10.1039/C1CE90004H, Cover

This issue of CrystEngComm is a themed issue focussing on Crystal Growth, guest edited by Professor Jennifer Swift. Other articles in this exciting issue include communications and papers by Lara Estroff, Joanna Aizenberg, Bart Kahr and Allan Myerson. Browse the issue.

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CrystEngComm New Talent themed issue is published

Neil Champness is the guest editor of this issue showcasing the strength of research being carried out by
tomorrow’s leaders in the field of crystal engineering in its broadest sense, including crystal growth.

Articles in the issue include:

Dipyrrin based homo- and hetero-metallic infinite architectures
Stéphane A. Baudron, CrystEngComm, 2010, DOI: 10.1039/c001020k

Self-assembly of 1,4-cis-polybutadiene and an aromatic host to fabricate nanostructured crystals
by π…CH interactions
Silvia Bracco, Angiolina Comotti, Patrizia Valsesia, Mario Beretta and Piero Sozzani
CrystEngComm, 2010, DOI: 10.1039/c002931a

Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin
heptahydrate

Francesca P. A. Fabbiani, Demetrius C. Levendis, Gernot Buth, Werner F. Kuhs, Norman
Shankland and Heidrun Sowa, CrystEngComm, 2010, DOI: 10.1039/b924573a

Postsynthetic diazeniumdiolate formation and NO release from MOFs
Joseph G. Nguyen, Kristine K. Tanabe and Seth M. Cohen
CrystEngComm, 2010, DOI: 10.1039/c000154f

 Explore other articles in this exciting themed issue here!

front cover image for CrystEngComm, Issue 8, 2010

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