In their recent CrystEngComm Hot Article, Katarzyna Solanko and Andrew Bond, from the University of Southern Denmark, looked at solution crystallisations of 5-X-aspirin (X = ¼ Cl, Br) to investigate if the polymorphism was affected by the presence of analgous aspirin anhydride species. The group show that small changes in temperature when the compound is being made can lead to erratic and apparently irreproducible crystallisation results, especially if the impurities remain undetected.
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Influence of impurities on the crystallisation of 5-X-aspirin and 5-X-aspirin anhydride polymorphs (X = Cl, Br, Me)
Katarzyna A. Solanko and Andrew D. Bond.
CrystEngComm, 2011, DOI: 10.1039/C1CE06065A
