Eye infection treatments that resist being blinked away could be formulated by cocrystallising an antibiotic with caffeine.
Cocrystallising sulfacetamide (left) with caffeine (right) makes it less soluble
Sulfacetamide (SACT) is often lost on blinking and in tears when applied as a treatment for conjunctivitis and other ocular ailments. This leads to the inconvenience and complications of applying larger and more frequent doses of SACT….’
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Modulating the solubility of Sulfacetamide by means of cocrystals†
Ashwini Nangia, Rajesh Goud and Ronaq Ali Khan
CrystEngComm, 2014, Accepted Manuscript
DOI: 10.1039/C4CE00103F, Paper
