Polymorphism co-crystal screening

This article is HOT as recommended by the referees. And we’ve made it free to access for 4 weeks.

In their HOT article, Jones and co-workers at the University of Cambridge present a comprehensive crystal form screen for the phenazine:mesaconic acid system, employing a variety of different co-crystallisation methods.
Phenazine:mesaconic acid system
Phenazine:mesaconic acid system

The researchers identified and characterised three anhydrous co-crystal polymorphs, one co-crystal hydrate and one DMSO co-crystal solvate, and also highlighted a novel co-crystallisation technique at the interface between two immiscible solutions, yielding a pure phenazine:mesaconic acid co-crystal form.   Traditional solvent-based methods usually used for polymorphism screening were inappropriate for this system due to the large differences in solubility of phenazine and mesaconic acid.

Read more about this study for FREE at:

Screening for polymorphs of cocrystals: a case study
Mark D. Eddleston, Saranja Sivachelvam and William Jones
CrystEngComm, 2012, Advance Article
DOI: 10.1039/C2CE26496J

You may also be interested in other recent work on co-crystals by the Jones group:

Cocrystal dissociation and molecular demixing in the solid state
Mark D. Eddleston, Gareth O. Lloyd and William Jones
Chem. Commun., 2012, 48, 8075-8077
DOI: 10.1039/C2CC33412G, Communication

A hydrogen bonded cocrystal with an unusual interweaving between the adjacent triple-helices
Amit Delori and William Jones
CrystEngComm, 2011, 13, 6315-6318
DOI: 10.1039/C1CE05534H, Communication

Observation of a two-dimensional halogen-bonded cocrystal at sub-monolayer coverage using synchrotron X-ray diffraction
Stuart M. Clarke, Tomislav Frišcic, William Jones, Anasuya Mandal, Chenguang Sun and Julia E. Parker
Chem. Commun., 2011, 47, 2526-2528
DOI: 10.1039/C0CC04400H, Communication

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