- Phenazine:mesaconic acid system
The researchers identified and characterised three anhydrous co-crystal polymorphs, one co-crystal hydrate and one DMSO co-crystal solvate, and also highlighted a novel co-crystallisation technique at the interface between two immiscible solutions, yielding a pure phenazine:mesaconic acid co-crystal form. Traditional solvent-based methods usually used for polymorphism screening were inappropriate for this system due to the large differences in solubility of phenazine and mesaconic acid.
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Screening for polymorphs of cocrystals: a case study
Mark D. Eddleston, Saranja Sivachelvam and William Jones
CrystEngComm, 2012, Advance Article
DOI: 10.1039/C2CE26496J
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A hydrogen bonded cocrystal with an unusual interweaving between the adjacent triple-helices
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Observation of a two-dimensional halogen-bonded cocrystal at sub-monolayer coverage using synchrotron X-ray diffraction
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