In this CrystEngComm Hot Article, Akio Ichikawa and colleagues from Tsukuba and Nara, Japan, report that a methoxy-assisted salt bridge is important for chiral recognition in the crystalline diastereomeric salts prepared from (R)- and (S)-2-methoxy-2-(1-naphthyl)propanoic acid with (R)-1-phenylethylamine.
The authors predict that the findings will be useful in the crystal engineering of 2-aryl-2-methoxypropanoic acid derivatives for the development of single-enantiomer biofunctional molecules, agrochemicals and pharmaceuticals.
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Crystal structures and chiral recognition of the diastereomeric salts prepared from 2-methoxy-2-(1-naphthyl)propanoic acid
Akio Ichikawa, Hiroshi Ono, Takuya Echigo and Yuji Mikata
CrystEngComm, 2011, Advance Article
DOI: 10.1039/C1CE05155E, Paper
